ChemicalBook >> CAS DataBase List >>5,6,7a,11-Tetraazacyclohepta[def]cyclopenta[a]fluoren-4(7H)-one, 2-fluoro-5,8,9,10,10a,11-hexahydro-10a-methyl-, (10aR)-, (2Z)-2-butenedioate (2:3)
5,6,7a,11-Tetraazacyclohepta[def]cyclopenta[a]fluoren-4(7H)-one, 2-fluoro-5,8,9,10,10a,11-hexahydro-10a-methyl-, (10aR)-, (2Z)-2-butenedioate (2:3)
- CAS No.
- 2086689-94-1
- Chemical Name:
- 5,6,7a,11-Tetraazacyclohepta[def]cyclopenta[a]fluoren-4(7H)-one, 2-fluoro-5,8,9,10,10a,11-hexahydro-10a-methyl-, (10aR)-, (2Z)-2-butenedioate (2:3)
- Synonyms
- BGB-29 maleat 0;Pamiparib maleate;5,6,7a,11-Tetraazacyclohepta[def]cyclopenta[a]fluoren-4(7H)-one, 2-fluoro-5,8,9,10,10a,11-hexahydro-10a-methyl-, (10aR)-, (2Z)-2-butenedioate (2:3)
- CBNumber:
- CB69926495
- Molecular Formula:
- C20H19FN4O5
- Molecular Weight:
- 414.39
- MDL Number:
- MOL File:
- 2086689-94-1.mol
Last updated:2023-03-31 09:12:57
5,6,7a,11-Tetraazacyclohepta[def]cyclopenta[a]fluoren-4(7H)-one, 2-fluoro-5,8,9,10,10a,11-hexahydro-10a-methyl-, (10aR)-, (2Z)-2-butenedioate (2:3) Chemical Properties,Uses,Production
Description
Pamiparib, also known as BGB-290, is a highly potent and selective PARP inhibitor with favorable drug metabolism and pharmacokinetic properties. BGB-290 selectively binds to PARP and prevents PARP-mediated repair of single-strand DNA breaks via the base-excision repair (BER) pathway. This enhances the accumulation of DNA strand breaks, promotes genomic instability, and eventually leads to apoptosis. BGB-290 may both potentiate the cytotoxicity of DNA-damaging agents and reverse tumor cell chemo- and radioresistance.
5,6,7a,11-Tetraazacyclohepta[def]cyclopenta[a]fluoren-4(7H)-one, 2-fluoro-5,8,9,10,10a,11-hexahydro-10a-methyl-, (10aR)-, (2Z)-2-butenedioate (2:3) Preparation Products And Raw materials
Raw materials
Preparation Products
5,6,7a,11-Tetraazacyclohepta[def]cyclopenta[a]fluoren-4(7H)-one, 2-fluoro-5,8,9,10,10a,11-hexahydro-10a-methyl-, (10aR)-, (2Z)-2-butenedioate (2:3) Suppliers
Global( 4)Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
InvivoChem | 13549236410 | sales@invivochem.cn | China | 6755 | 58 |
TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 23963 | 58 |
Supplier | Advantage |
---|---|
TargetMol Chemicals Inc. | 58 |
InvivoChem | 58 |
InvivoChem | 58 |
TargetMol Chemicals Inc. | 58 |
5,6,7a,11-Tetraazacyclohepta[def]cyclopenta[a]fluoren-4(7H)-one, 2-fluoro-5,8,9,10,10a,11-hexahydro-10a-methyl-, (10aR)-, (2Z)-2-butenedioate (2:3)
Pamiparib maleate
BGB-29 maleat 0
2086689-94-1
C20H19FN4O5