MECLOFENAMATE SODIUM
- CAS No.
- 6385-02-0
- Chemical Name:
- MECLOFENAMATE SODIUM
- Synonyms
- ci583;C02996;Movens;meclomen;Meclonax;Meclofenamate;sodiummeclophenamate;SODIUM MECLOFENAMATE;MECLOFENAMATE SODIUM;MECLOFENAMATESODIUM,USP
- CBNumber:
- CB7102365
- Molecular Formula:
- C14H10Cl2NO2.Na
- Molecular Weight:
- 318.13
- MDL Number:
- MFCD00941475
- MOL File:
- 6385-02-0.mol
- MSDS File:
- SDS
Melting point | 287-291 °C |
---|---|
storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
solubility | DMSO (Slightly), Methanol (Slightly) |
form | White solid. |
color | White to Off-White |
Water Solubility | Soluble in water at 50mg/ml. Also soluble in DMF, DMSO or ethanol |
Merck | 14,5779 |
Stability | Hygroscopic |
FDA UNII | 9MMQ0YER4E |
NCI Drug Dictionary | meclofenamate sodium |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07 |
|||||||||
---|---|---|---|---|---|---|---|---|---|---|
Signal word | Warning | |||||||||
Hazard statements | H302 | |||||||||
Precautionary statements | P280-P305+P351+P338 | |||||||||
WGK Germany | 3 | |||||||||
RTECS | CB2975500 | |||||||||
HS Code | 2922498050 | |||||||||
NFPA 704 |
|
MECLOFENAMATE SODIUM price More Price(26)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | M4531 | Meclofenamic acid sodium salt | 6385-02-0 | 1g | $56.6 | 2024-03-01 | Buy |
Sigma-Aldrich | 1377803 | Meclofenamate Sodium United States Pharmacopeia (USP) Reference Standard | 6385-02-0 | 500mg | $467 | 2024-03-01 | Buy |
TCI Chemical | M1269 | Sodium Meclofenamate | 6385-02-0 | 1G | $63 | 2024-03-01 | Buy |
TCI Chemical | M1269 | Sodium Meclofenamate Hydrate >98.0%(HPLC)(N) | 6385-02-0 | 10g | $372 | 2024-03-01 | Buy |
Alfa Aesar | J60484 | Meclofenamic acid sodium salt, 99+% | 6385-02-0 | 1g | $43.65 | 2024-03-01 | Buy |
MECLOFENAMATE SODIUM Chemical Properties,Uses,Production
Description
Meclofenamate is a time-
Originator
Meclomen,Warner Lambert,US,1980
Uses
antiinflammatory, antipyretic
Uses
Meclofenamate Sodium is an NSAID used in the treatment of chronic pain.
Definition
ChEBI: An organic sodium salt derived from meclofenamic acid. Its monohydrate is used for the treatment of dysmenorrhoea (painful periods), osteoarthritis and rheumatoid arthritis.
Indications
Meclofenamate sodium (Meclomen) is prescribed for rheumatoid arthritis and osteoarthritis. The fenamates show no clear superiority in antiinflammatory activity and may produce more adverse effects than other NSAIDs.
Manufacturing Process
A mixture consisting of 22.7 g potassium o-bromobenzoate, 16.6 g 2,6- dichloro-3-methylaniline, 12 ml N-ethylmorpholine, 60 ml diethylene glycol dimethyl ether, and 1.0 g anhydrous cupric bromide is heated in a nitrogen atmosphere at 145°C to 155°C for 2 hours. The reaction mixture is diluted with 60 ml diethylene glycol dimethyl ether and acidified with 25 ml concentrated hydrochloric acid. The acidic mixture is diluted with 100 ml of water and the liquid phase decanted from the insoluble oil. The insoluble oil is stirred with methanol and the crystalline N-(2,6-dichloro-3-methylphenyl) anthranilic acid which separates is collected and washed with methanol. The product, after recrystallization from acetone-water mixture, melts at 248°C to 250°C.
brand name
Meclomen (Parke-Davis).
Therapeutic Function
Antiinflammatory
General Description
Meclofenamate sodium (Meclomen) is available for use inthe treatment of acute and chronic RA, OA, and primarydysmenorrhea. It is metabolized in a similar manner tomefenamic acid discussed above, thus a similar restriction isalso applied to meclofenamate. The most significant side effectsare GI, including diarrhea.
Pharmacokinetics
Meclofenamate sodium is rapidly and almost completely absorbed following oral administration, reaching peak plasma
levels within 2 hours. It is highly bound to plasma proteins (99%) and has a plasma half-life of 2 to 4 hours.
Metabolism involves oxidation of the methyl group, aromatic hydroxylation, monodehalogenation, and conjugation.
Urinary excretion accounts for approximately 75% of the administered dose. The major metabolite is the product of
3′-methyl oxidation and has been shown to possess anti-inflammatory activity.
Clinical Use
Meclofenamate sodium is indicated for the relief of mild to moderate pain, the acute and chronic treatment of rheumatoid arthritis and osteoarthritis, the treatment of primary dysmenorrhea, and the treatment of idiopathic, heavy menstrual blood loss.
MECLOFENAMATE SODIUM Preparation Products And Raw materials
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49391 | 58 |
Shaanxi Dideu Medichem Co. Ltd | +86-29-87569265 +86-18612256290 | 1056@dideu.com | China | 2336 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 26466 | 58 |
AFINE CHEMICALS LIMITED | +86-0571-85134551 | info@afinechem.com | China | 15395 | 58 |
Dayang Chem (Hangzhou) Co.,Ltd. | 571-88938639 +8617705817739 | info@dycnchem.com | China | 52861 | 58 |
InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
GIHI CHEMICALS CO.,LIMITED | +8618058761490 | info@gihichemicals.com | China | 49999 | 58 |
LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43348 | 58 |
Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
View Lastest Price from MECLOFENAMATE SODIUM manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2021-07-20 | SodiuM MeclofenaMate Monohydrate
6385-02-0
|
US $1.00-1.00 / KG | 1g | 99% | 50tons | Shaanxi Dideu Medichem Co. Ltd | ||
2021-06-10 | MECLOFENAMATE SODIUM USP/EP/BP
6385-02-0
|
US $1.10 / g | 1g | 99.9% | 100 Tons Min | Dideu Industries Group Limited |
- SodiuM MeclofenaMate Monohydrate
6385-02-0
- US $1.00-1.00 / KG
- 99%
- Shaanxi Dideu Medichem Co. Ltd
- MECLOFENAMATE SODIUM USP/EP/BP
6385-02-0
- US $1.10 / g
- 99.9%
- Dideu Industries Group Limited
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