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ChemicalBook >> CAS DataBase List >>2,8-Diazaspiro[4.5]decan-1-one, 8-[3-chloro-5-(1-methyl-1H-indazol-5-yl)-1H-pyrazolo[3,4-b]pyridin-4-yl]-

2,8-Diazaspiro[4.5]decan-1-one, 8-[3-chloro-5-(1-methyl-1H-indazol-5-yl)-1H-pyrazolo[3,4-b]pyridin-4-yl]-

2,8-Diazaspiro[4.5]decan-1-one, 8-[3-chloro-5-(1-methyl-1H-indazol-5-yl)-1H-pyrazolo[3,4-b]pyridin-4-yl]- Structure
2,8-Diazaspiro[4.5]decan-1-one, 8-[3-chloro-5-(1-methyl-1H-indazol-5-yl)-1H-pyrazolo[3,4-b]pyridin-4-yl]- structure
CAS No.
2648453-53-4
Chemical Name:
2,8-Diazaspiro[4.5]decan-1-one, 8-[3-chloro-5-(1-methyl-1H-indazol-5-yl)-1H-pyrazolo[3,4-b]pyridin-4-yl]-
Synonyms
JH-XVI-178;2,8-Diazaspiro[4.5]decan-1-one, 8-[3-chloro-5-(1-methyl-1H-indazol-5-yl)-1H-pyrazolo[3,4-b]pyridin-4-yl]-
CBNumber:
CB710622130
Molecular Formula:
C22H22ClN7O
Molecular Weight:
435.91
MDL Number:
MOL File:
2648453-53-4.mol
Last updated:2024-07-02 08:55:14
Request For Quotation

2,8-Diazaspiro[4.5]decan-1-one, 8-[3-chloro-5-(1-methyl-1H-indazol-5-yl)-1H-pyrazolo[3,4-b]pyridin-4-yl]- Properties

Boiling point 782.1±60.0 °C(Predicted)
Density 1.60±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
pka 9.84±0.40(Predicted)
form Solid
color White to off-white

2,8-Diazaspiro[4.5]decan-1-one, 8-[3-chloro-5-(1-methyl-1H-indazol-5-yl)-1H-pyrazolo[3,4-b]pyridin-4-yl]- Chemical Properties,Uses,Production

Biological Activity

JH-XVI-178 is a highly potent and selective inhibitor of CDK8/19 that displays low clearance and moderate oral pharmacokinetic properties.

References

[1]. Hatcher JM, et al. Development of Highly Potent and Selective Pyrazolopyridine Inhibitor of CDK8/19. ACS Med Chem Lett. 2021 Oct 22;12(11):1689-1693.

2,8-Diazaspiro[4.5]decan-1-one, 8-[3-chloro-5-(1-methyl-1H-indazol-5-yl)-1H-pyrazolo[3,4-b]pyridin-4-yl]- Preparation Products And Raw materials

Raw materials

Preparation Products

2,8-Diazaspiro[4.5]decan-1-one, 8-[3-chloro-5-(1-methyl-1H-indazol-5-yl)-1H-pyrazolo[3,4-b]pyridin-4-yl]- Suppliers

Global( 3)Suppliers
Supplier Tel Email Country ProdList Advantage
Aladdin Scientific 		+1-+1(833)-552-7181 sales@aladdinsci.com United States 52927 58
Suzhou youruike Chemical Pharmaceutical Technology Co., Ltd 15317229551 15151849396@163.com China 994 58
TargetMol Chemicals Inc. 15002134094 marketing@targetmol.cn China 28091 58
Supplier Advantage
Aladdin Scientific 		58
Suzhou youruike Chemical Pharmaceutical Technology Co., Ltd 58
TargetMol Chemicals Inc. 58
2,8-Diazaspiro[4.5]decan-1-one, 8-[3-chloro-5-(1-methyl-1H-indazol-5-yl)-1H-pyrazolo[3,4-b]pyridin-4-yl]- JH-XVI-178 2648453-53-4