ailanthone
- CAS No.
- 981-15-7
- Chemical Name:
- ailanthone
- Synonyms
- ailanthone;Δ13-Dehydrochaparrinone;Ailanthone, 10 mM in DMSO;13,21-Didehydrochaparrinone;2H-1,11c-(Epoxymethano)phenanthro[10,1-bc]pyran-5,10(3H,6aH);(1beta,11alpha,12alpha)-1,11,12-trihydroxy-11,20-epoxypicras...;11β,20-Epoxy-1β,11,12α-trihydroxypicrasa-3,13(21)-diene-2,16-dione;(1β,11β,12α)-11,20-Epoxy-1,11,12-trihydroxypicrasa-3,13(21)-diene-2,16-dione;Picrasa-3,13(21)-diene-2,16-dione,11,20-epoxy-1,11,12-trihydroxy-, (1b,11b,12a)-;Picrasa-3,13(21)-diene-2,16-dione, 11,20-epoxy-1,11,12-trihydroxy-, (1β,11β,12α)-
- CBNumber:
- CB71327541
- Molecular Formula:
- C20H24O7
- Molecular Weight:
- 376.4
- MDL Number:
- MFCD01729487
- MOL File:
- 981-15-7.mol
- MSDS File:
- SDS
| Melting point | 235-237 °C |
|---|---|
| Boiling point | 641.0±55.0 °C(Predicted) |
| Density | 1.47 |
| storage temp. | Sealed in dry,Store in freezer, under -20°C |
| solubility | DMSO:100.0(Max Conc. mg/mL);265.67(Max Conc. mM) |
| form | A crystalline solid |
| pka | 11.85±0.70(Predicted) |
| color | White to off-white |
| LogP | -0.760 (est) |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H300 | |||||||||
| Precautionary statements | P301+P330+P331+P310 | |||||||||
| NFPA 704 |
|
ailanthone price More Price(22)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML2143 | Ailanthone ≥98% (HPLC) | 981-15-7 | 5MG | $143 | 2023-06-20 | Buy |
| Sigma-Aldrich | SML2143 | Ailanthone ≥98% (HPLC) | 981-15-7 | 25MG | $567 | 2023-06-20 | Buy |
| Cayman Chemical | 29194 | Ailanthone | 981-15-7 | 5mg | $116 | 2024-03-01 | Buy |
| Cayman Chemical | 29194 | Ailanthone | 981-15-7 | 25mg | $485 | 2024-03-01 | Buy |
| Cayman Chemical | 29194 | Ailanthone | 981-15-7 | 1mg | $37 | 2024-03-01 | Buy |
ailanthone Chemical Properties,Uses,Production
Description
Ailanthone is a quassinoid that has been found in Ailanthus and has diverse biological activities. It is active against the P. falciparum strains HB-3 and Dd-2 in vitro (IC50s = 0.003 and 0.037 μg/ml, respectively). Ailanthone is phytotoxic, inhibiting radish seed germination by 88% when used at a concentration of 1 mM. It inhibits dihydrotestosterone-induced androgen receptor transcriptional activity (IC50 = 69 nM in a reporter assay), as well as the growth and colony formation of LNCaP and 22RV1 androgen receptor-expressing cells, but not androgen receptor-negative PC3 and DU145 cells, when used at a concentration of 0.1 μM. Ailanthone (2 mg/kg) reduces tumor volume in 22Rv1, LNCaP, and VCaP castration-resistant prostate cancer (CRPC) mouse xenograft models.
Uses
Ailanthone has potent antineoplastic activity against anti-hepatocellular carcinoma (HCC) and has been shown to inhibit Huh7 cancer cell growth through cell cycle arrest and apoptosis in vitro and in vivo.
Definition
ChEBI: Ailanthone is a triterpenoid.
in vivo
Not only i.p. administration but also p.o. administration of Ailanthone has excellent efficiency for blocking the growth of CRPC xenografts. In pharmacokinetic studies, Ailanthone exhibits good solubility in water and good bioavailability (>20%). In addition, Ailanthone effectively suppresses CRPC tumour growth, despite not reaching a steady state of plasma drug concentration during the course of treatment[1].
ailanthone Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Zheyan Biotech Co., Ltd. | 18017610038 | zheyansh@163.com | CHINA | 3619 | 58 |
| Chengdu Biopurify Phytochemicals Ltd. | +86-28-82633860; +8618080483897 | sales@biopurify.com | China | 3772 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28172 | 58 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22963 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29808 | 58 |
| Wuhan ChemNorm Biotech Co.,Ltd. | +86-27-8439 4403 18971486879 | sales@chemnorm.com | CHINA | 2935 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +8618949823763 | sales@tnjchem.com | China | 34563 | 58 |
| Aktin Chemicals, Inc. | 028-85159085 | info@aktinchem.com | CHINA | 1025 | 58 |
| ANHUI WITOP BIOTECH CO., LTD | +8615255079626 | eric@witopchemical.com | China | 23541 | 58 |
| Labnetwork lnc. | +86-27-50766799 +8618062016861 | contact@labnetwork.com | China | 19987 | 58 |
View Lastest Price from ailanthone manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-11-19 | Ailanthone
981-15-7
|
US $36.00-118.00 / mg | 99.78% | 10g | TargetMol Chemicals Inc. | ||
 |
2020-01-13 | ailanthone
981-15-7
|
US $9.80 / KG | 1KG | ≥98% | 20 tons | Career Henan Chemical Co |
-
- Ailanthone
981-15-7
- US $36.00-118.00 / mg
- 99.78%
- TargetMol Chemicals Inc.
-
- ailanthone
981-15-7
- US $9.80 / KG
- ≥98%
- Career Henan Chemical Co