BI-2865
- CAS No.
- 2937327-93-8
- Chemical Name:
- BI-2865
- Synonyms
- BI-2865
- CBNumber:
- CB713546660
- Molecular Formula:
- C23H27N7O2S
- Molecular Weight:
- 465.57
- MDL Number:
- MOL File:
- 2937327-93-8.mol
BI-2865 Chemical Properties,Uses,Production
Description
BI-2865 is a none-covalent pan-KRAS Inhibitor. BI-2865 blocked nucleotide exchange to prevent the activation of wild-type KRAS and a broad range of KRAS mutants, including G12A/C/D/F/V/S, G13C/D, V14I, L19F, Q22K, D33E, Q61H, K117N and A146V/T. Inhibition of downstream signaling and proliferation was restricted to cancer cells harboring mutant KRAS, and drug treatment suppressed KRAS mutant tumor growth in mice without having a detrimental effect on animal weight.
Biological Activity
BI-2865 is a non-covalent pan-KRAS inhibitor that binds to KRAS WT, G12C, G12D, G12V, and G13D mutants with Kd values of 6.9 nM, 4.5 nM, 32 nM, 26 nM, and 4.3 nM, respectively. It can be used in studies related to KRAS mutant tumors.
in vitro
BI-2865 is a derivative with a prolinol substituent and a pyrimidine linker. BI-2865 has direct ionic interaction with E62 and a water-mediated hydrogen bond network with the side chain of R68 and the main chain carbonyl of Q61. BI-2865 (5 days) inhibits the proliferation of G12C, G12D, or G12V mutant KRAS expressing BaF3 cells in the presence of IL-13, with a mean IC50 of roughly 140?nM.
BI-2865 Preparation Products And Raw materials
Raw materials
Preparation Products
BI-2865 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hubei Chuchang Biotech Co., Ltd. | +86-18727130788 +86-18727130788 | info@chuchangbiotech.com | China | 109 | 58 |
| Hubei Chuchang Chemical Co., Ltd | 15623560702 | Joy.Ren@aliyun.com | China | 144 | 58 |
| Nantong QuanYi Biotechnology Co., Ltd | 0513-66337626 18051384581 | sales@chemhifuture.com | China | 4455 | 58 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4197 | 55 | |
| Changzhou Borl Biotechnology Co.,LTD | 13606124132;13656121842 | luyan0021@163.com | China | 217 | 58 |
| ShangHai Caerulum Pharma Discovery Co., Ltd. | 18149758185 | sales-cpd@caerulumpharma.com | China | 3453 | 58 |
| Shanghai Pansopharm Technology Co., Ltd. | 021-20962833 15316628753 | sales@pansopharm.com | China | 480 | 60 |
| ShangHai Angti Biotechnology Co., Ltd. | 13764913901 | info@angtibio.com | China | 4869 | 55 |
| ShangHai Biochempartner Co.,Ltd | 17754423994 17754423994 | 2853530910@QQ.com | China | 8012 | 62 |
| Shanghai Rechem science Co., Ltd. | 21-31433387 15618786686 | sales@rechemscience.com | China | 2986 | 58 |
