darbepoetin alfa
- CAS No.
- 209810-58-2
- Chemical Name:
- darbepoetin alfa
- Synonyms
- Aranesp;Krn 321;Hsdb 7583;Unii-15uq94pt4p;darbepoetin alfa
- CBNumber:
- CB71370390
- Molecular Formula:
- Molecular Weight:
- 0
- MDL Number:
- MFCD04113365
- MOL File:
- Mol file
| NCI Dictionary of Cancer Terms | Aranesp; darbepoetin alfa |
|---|---|
| FDA UNII | 15UQ94PT4P |
| NCI Drug Dictionary | Aranesp |
| ATC code | B03XA02 |
darbepoetin alfa Chemical Properties,Uses,Production
Uses
Treatment of anemia.
Clinical Use
Treatment of anaemia associated with chronic renal failure, and with non-haematological malignancies in adult cancer patients receiving chemotherapy
Veterinary Drugs and Treatments
Darbepoetin may potentially be useful in treating anemia of chronic kidney disease in dogs and cats. It may be less immunogenic than epoetin, but this is only theoretical and has not been documented. Another advantage is that doses may be administered less often to maintain PCV. Treatment costs may be higher than using epoetin, however.
Metabolism
The metabolic fate of both endogenous and recombinant
erythropoietin is poorly understood. Current evidence
from studies in animals suggests that hepatic metabolism
contributes only minimally to elimination of the intact
hormone, but desialylated epoetin (ie, terminal sialic
acid groups removed) appears to undergo substantial
hepatic clearance via metabolic pathways and/or binding.
Desialylation and/or removal of the oligosaccharide side
chains of erythropoietin appear to occur principally in the
liver; bone marrow also may have a role in catabolism of
the hormone.
Elimination of desialylated drug by the kidneys, bone
marrow, and spleen also may occur; results of animal
studies suggest that proximal renal tubular secretion may
be involved in renal elimination. In preclinical studies it
has been shown that renal clearance of darbepoetin is
minimal (up to 2% of total clearance).
darbepoetin alfa Preparation Products And Raw materials
Raw materials
Preparation Products
darbepoetin alfa Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Beijing HuaMeiHuLiBiological Chemical | 010-56205725 | waley188@sohu.com | China | 12338 | 58 |
| Conier Chem & Pharma Limited | 13368167990 | sales@conier.com | China | 2809 | 58 |
| Supplier | Advantage |
|---|---|
| Beijing HuaMeiHuLiBiological Chemical | 58 |
| Conier Chem & Pharma Limited | 58 |
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