17-(DIMETHYLAMINOETHYLAMINO)-17-DEMETHOXYGELDANAMYCIN HCL
- CAS No.
- 150270-08-9
- Chemical Name:
- 17-(DIMETHYLAMINOETHYLAMINO)-17-DEMETHOXYGELDANAMYCIN HCL
- Synonyms
- DL 3631;GledanaMycin;Geldanamycin, 4,5-dihydro-;17-(DIMETHYLAMINOETHYLAMINO)-17-DEMETHOXYGELDANAMYCIN HCL
- CBNumber:
- CB71497112
- Molecular Formula:
- C29H42N2O9
- Molecular Weight:
- 562.65
- MDL Number:
- MFCD08457919
- MOL File:
- 150270-08-9.mol
- MSDS File:
- SDS
Boiling point | 767.9±60.0 °C(Predicted) |
---|---|
Density | 1.22±0.1 g/cm3(Predicted) |
RTECS | LX8925000 |
storage temp. | -20°C |
solubility | Soluble in DMSO (up to 30 mg/ml) or in Ethanol (up to 10 mg/ml). |
form | solid |
pka | 8.88±0.70(Predicted) |
color | Purple |
Sensitive | Light Sensitive |
Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months. |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07 |
---|---|
Signal word | Warning |
Hazard statements | H315-H319-H335 |
Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a |
17-(DIMETHYLAMINOETHYLAMINO)-17-DEMETHOXYGELDANAMYCIN HCL price More Price(7)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Alfa Aesar | J67023 | 17-DMAG, 98% | 150270-08-9 | 1mg | $317 | 2021-12-16 | Buy |
American Custom Chemicals Corporation | INB0000693 | 17-[2-(DIMETHYLAMINO)ETHYL]AMINO-17-DESMETHOXYGELDANAMYCIN 95.00% | 150270-08-9 | 10MG | $650.27 | 2021-12-16 | Buy |
American Custom Chemicals Corporation | INB0000693 | 17-[2-(DIMETHYLAMINO)ETHYL]AMINO-17-DESMETHOXYGELDANAMYCIN 95.00% | 150270-08-9 | 50MG | $752.14 | 2021-12-16 | Buy |
American Custom Chemicals Corporation | INB0000693 | 17-[2-(DIMETHYLAMINO)ETHYL]AMINO-17-DESMETHOXYGELDANAMYCIN 95.00% | 150270-08-9 | 250MG | $868.56 | 2021-12-16 | Buy |
Matrix Scientific | 089480 | 17-Dimethylaminogeldanamycin | 150270-08-9 | 10mg | $1890 | 2021-12-16 | Buy |
17-(DIMETHYLAMINOETHYLAMINO)-17-DEMETHOXYGELDANAMYCIN HCL Chemical Properties,Uses,Production
Description
17-DMAG (150270-08-9) is an analog of geldanamycin (Cat.# 10-1084) that displays superior pharmacological properties. 17-DMAG inhibits HSP90 and induces apoptosis in a variety of tumor cell lines. Inhibits angiogenesis. Cell Permeable.
Uses
17-Dimethylaminogeldanamycin is a metabolite/analog of geldanamycin(G304500). Geldanamycin is a potent antitumor antibiotic active at nanomolar concentration against 60 cell lines.It binds specifically to the heat shock protein Hsp90 and to its endoplasmic reticulum homologue GP96, and thus interferes with conformational maturation of proteins and the cellular stress response. In addition, it is a potent inhibitor of the nuclear hormone receptor family.
Definition
ChEBI: Alvespimycin is a 19-membered macrocyle that is geldanamycin in which the methoxy group attached to the benzoquinone moiety has been replaced by a 2-(N,N-dimethylamino)ethylamino group. It has a role as a Hsp90 inhibitor. It is a secondary amino compound, a tertiary amino compound, an ansamycin, a member of 1,4-benzoquinones and a carbamate ester. It is functionally related to a geldanamycin.
References
1) Glaze et al. (2005), Preclinical toxicity of geldanamycin analog 17-(dimethylaminoethylamino)-demethoxygeldanamycin (17-DMAG) in rats and dogs; potential clinical relevance; Cancer Chemother. Pharmacol., 56 637 2) Kaur et al. (2004), Antiangiogenic properties of 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin: an orally bioavailable heat shock protein 90 modulator; Clin. Cancer Res., 10 4813
17-(DIMETHYLAMINOETHYLAMINO)-17-DEMETHOXYGELDANAMYCIN HCL Preparation Products And Raw materials
Raw materials
Preparation Products
17-(DIMETHYLAMINOETHYLAMINO)-17-DEMETHOXYGELDANAMYCIN HCL Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49739 | 58 |
Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131980 | 58 |
Shanghai Boyle Chemical Co., Ltd. | 021-50182298 021-50180596 | sales@boylechem.com | China | 2210 | 55 |
J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 96815 | 76 |
Sichuan Wei Keqi Biological Technology Co., Ltd. | 028-81700200 18116577057 | 3003855609@qq.com | China | 7887 | 56 |
Shenzhen Regent Biochemical Technology Co., Ltd. | 0755-0755-85201366 18938635012 | sales@regentsciences.com | China | 9300 | 58 |
Shenzhen Polymeri Biochemical Technology Co., Ltd. | +86-400-002-6226 13028896684 | sales@rrkchem.com | China | 56070 | 58 |