Picotamide
- CAS No.
- 32828-81-2
- Chemical Name:
- Picotamide
- Synonyms
- g137;PICOTAMIDE;N,N’-Bis(3-Pyridinylmethyl)-4-Me;n,n’-bis(3-picolyl)-4-methoxyisophthalamide;4-methoxy-n,n’-bis(3-pyridylmethyl)isophthalamide;4-methoxy-n,n’-bis(3-pyridylmethyl)-isophthalamid;4-methoxy-N,N'-bis(3-pyridylmethyl)isophthaldiamide;Isophthalamide, 4-methoxy-N,N'-bis(3-pyridylmethyl)-;n,n’-bis(3-pyridinylmethyl)-4-methoxy-3-benzenedicarboxamide;4-METHOXY-N,N'-BIS(3-PYRIDINYLMETHYL)-1,3-BENZENEDICARBOXAMIDE
- CBNumber:
- CB7167904
- Molecular Formula:
- C21H20N4O3
- Molecular Weight:
- 376.41
- MDL Number:
- MFCD00866792
- MOL File:
- 32828-81-2.mol
Melting point | 128-131℃ |
---|---|
Boiling point | 668.1±55.0 °C(Predicted) |
Density | 1.246±0.06 g/cm3(Predicted) |
storage temp. | -20°C |
solubility | Soluble in DMSO (up to 40 mg/ml) or in Ethanol (up to 5 mg/ml with warming). |
pka | 13.31±0.46(Predicted) |
form | White solid. |
color | White |
Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month. |
FDA UNII | 654G2VCI4Q |
ATC code | B01AC03 |
SAFETY
Risk and Safety Statements
Hazard statements | H303 |
---|---|
Precautionary statements | P270-P301+P312-P403-P501c |
WGK Germany | 2 |
RTECS | CZ2235500 |
Toxicity | LD50 i.p. in male mice: 1205 mg/kg (Orzalesi, Selleri, 1976) |
Picotamide price More Price(9)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | P8477 | Picotamide | 32828-81-2 | 5mg | $277 | 2024-03-01 | Buy |
Alfa Aesar | J67232 | Picotamide, 98% | 32828-81-2 | 10mg | $144.9 | 2023-01-06 | Buy |
Cayman Chemical | 21690 | Picotamide ≥98% | 32828-81-2 | 5mg | $62 | 2024-03-01 | Buy |
Cayman Chemical | 21690 | Picotamide ≥98% | 32828-81-2 | 10mg | $109 | 2024-03-01 | Buy |
Cayman Chemical | 21690 | Picotamide ≥98% | 32828-81-2 | 25mg | $239 | 2024-03-01 | Buy |
Picotamide Chemical Properties,Uses,Production
Description
Picotamide is an unique antithrombotic agent which acts by selectively inhibiting thromboxane synthesis and blocking platelet thromboxane receptors without affecting prostaglandin synthesis. It is reported to be useful in the treatment of myocardial infarction, cerebrovascular disorders, pulmonary embolism and atherosclerosis.
Originator
Manetti-Roberts (Beecham (Italy)
Uses
Keratolytic.
Uses
Picotamide is a dual inhibitor of thromboxane A2 and thromboxane A2 synthase. It is used in aptamers for targeting coagulation factor XIII and there used for treatment of thrombosis.
Definition
ChEBI: 4-methoxy-N1,N3-bis(3-pyridinylmethyl)benzene-1,3-dicarboxamide is a member of benzamides.
brand name
Plactidil
References
Modesti, et al. (1989), Competitive inhibition of platelet thromboxane A2 receptor binding by picotamide; Eur. J. Pharmacol.. 169 85 Modesti, et al. (1991), Acute reduction of TxA2 platelet binding sites after in vivo administration of a TxA2 inhibitor; Br. J. Pharmacol.. 31 439 Ratti et al. (1998), Picotamide, an antithromboxane agent. Inhibits the migration and proliferation of arterial myocytes; Eur. J. Pharmacol. 355 77
Picotamide Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Hefei TNJ Chemical Industry Co.,Ltd. | 0551-65418671 | sales@tnjchem.com | China | 34571 | 58 |
Hefei Hirisun Pharmatech Co., Ltd | +8615056975894 | shawn@hirisunpharm.com | CHINA | 9923 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43348 | 58 |
Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
LGM Pharma | 1-(800)-881-8210 | inquiries@lgmpharma.com | United States | 2127 | 70 |
China Langchem Inc. | 0086-21-58956006 | China | 7815 | 57 | |
BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 14059 | 65 |
Shanghai TaoSu Biochemical Technology Co., Ltd. | 021-33632979 | info@tsbiochem.com | China | 8073 | 58 |
Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9707 | 58 |
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