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2-Amino-4-chloropyridine

2-Amino-4-chloropyridine structure

CAS No.: 19798-80-2

Chemical Name:: 2-Amino-4-chloropyridine

Synonyms: 4-CHLOROPYRIDIN-2-AMINE;4-chloro-2-pyridinamine;4-CHLORO-PYRIDINE-2-YLAMINE;DK765;cas:19798-80-2;IFLAB-BB F1926-0004;4-Chloropyrid-2-ylaMine;4-Chloro-2-amine-pyridin;2-Amino-4-Cholropyridine;4-Chloropyridine-2-amine

CBNumber:: CB7183078

Molecular Formula:: C5H5ClN2

Molecular Weight:: 128.56

MDL Number:: MFCD04113820

MOL File:: 19798-80-2.mol

MSDS File:: SDS

Last updated:2025-01-27 09:38:02

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2-Amino-4-chloropyridine Properties

Melting point	126-127°C
Boiling point	240.8±20.0 °C(Predicted)
Density	1.326±0.06 g/cm3(Predicted)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
solubility	DMSO, Methanol
form	Liquid
pka	5.72±0.11(Predicted)
color	Colorless to yellow to brown
λmax	294nm(CHCl3)(lit.)
Sensitive	Air & Moisture Sensitive
InChI	InChI=1S/C5H5ClN2/c6-4-1-2-8-5(7)3-4/h1-3H,(H2,7,8)
InChIKey	RQMWVVBHJMUJNZ-UHFFFAOYSA-N
SMILES	C1(N)=NC=CC(Cl)=C1
CAS DataBase Reference	19798-80-2(CAS DataBase Reference)
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302-H315-H319-H335

Precautionary statements

P261-P264-P270-P301+P312-P302+P352-P305+P351+P338

Hazard Codes

Xi,Xn

Risk Statements

22-36/37/38

Safety Statements

WGK Germany

HazardClass

IRRITANT

HS Code

29333990

NFPA 704

	1
2		0

2-Amino-4-chloropyridine price More Price(46)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	676020	2-Amino-4-chloropyridine 97%	19798-80-2	5g	$70.1	2023-06-20	Buy
Sigma-Aldrich	676020	2-Amino-4-chloropyridine 97%	19798-80-2	25g	$195	2023-06-20	Buy
TCI Chemical	A2152	2-Amino-4-chloropyridine >98.0%(GC)(T)	19798-80-2	5g	$79	2024-03-01	Buy
TCI Chemical	A2152	2-Amino-4-chloropyridine >98.0%(GC)(T)	19798-80-2	25g	$237	2024-03-01	Buy
Alfa Aesar	H59130	2-Amino-4-chloropyridine, 97%	19798-80-2	5g	$54.65	2024-03-01	Buy

Product number	Packaging	Price	Buy
676020	5g	$70.1	Buy
676020	25g	$195	Buy
A2152	5g	$79	Buy
A2152	25g	$237	Buy
H59130	5g	$54.65	Buy

2-Amino-4-chloropyridine Chemical Properties,Uses,Production

Chemical Properties

Light yellow Cryst

Uses

2-Amino-4-chloropyridine is a useful precursor that could be used to synthesize 2-amino-4,5-dichloropyridine, 2-amino-3,4-dichloropyridine, and 2-amino-3,4,5-trichloropyridine[1].

Synthesis Reference(s)

The Journal of Organic Chemistry, 72, p. 4554, 2007 DOI: 10.1021/jo070189y

Synthesis

Methyl 4-chloropicolinate hydrochloride in methanol was treated with hydrazine hydrate, resulting in the formation of a precipitate. The suspension was then stirred for 2 hours and the precipitated hydrazide was collected through filtration. The hydrazide was dissolved in 1N hydrochloric acid and the solution was cooled to a temperature between 0-5 ℃. A solution of sodium nitrite in water was then added dropwise, causing another precipitate to form. After stirring for 15 minutes, the precipitate was collected by filtration and washed with water. The moist precipitate was then combined with a mixture of acetic acid and water, and the resulting solution was heated in a steam bath until gas evolution stopped. The reaction mixture was cooled to room temperature, the pH was adjusted to 7, and the resulting precipitate was collected via filtration. Recrystallization using ethanol yielded 2-Amino-4-chloropyridine in the form of a white crystalline solid[1].

References

[1] Gudmundsson, Kristjan S. , et al. "An Improved Large Scale Synthesis of 2-Amino-4-chloropyridine and Its Use for the Convenient Preparation of Various Polychlorinated 2-Aminopyridines." Synthetic Communications 27.5(1997):861-870.

2-Amino-4-chloropyridine synthesis

Synthesis of 2-Amino-4-chloropyridine from (4-CHLORO-PYRIDIN-2-YL)-CARBAMIC ACID TERT-BUTYL ESTER

2-Amino-4-chloropyridine Preparation Products And Raw materials

Raw materials

Hexane Ammonium hydroxide Hydrazinium hydroxide solution Nitrogen N,N-Dimethylformamide

Potassium hydroxide Acetone Sodium bromide Calcium chloride Toluene

Sodium Hydrazine hydrate 1,4-Dioxane Sodium nitrite Tetrahydrofuran

Diethyl ether Ethyl acetate Government regulation Dichloromethane Acetic acid

Methanol Sodium hydroxide 2-Picolinic acid Thionyl chloride Sodium carbonate

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Preparation Products

2-Amino-4-methoxypyridine (4-METHOXY-PYRIDIN-2-YL)-CARBAMIC ACID TERT-BUTYL ESTER

2-Amino-4-chloropyridine Suppliers

Global( 665)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Blocksynth Pharmaceutical Technology Co.,Ltd	0086-19817745290; +8619817745290	bd@blocksynth.com	China	5661	58
Zhengzhou Lingzhiyue Technology Co., Ltd	+86-0371-55074660 +86-13783527580	Lingzhiyue@aliyun.com	China	3145	58
Wuhan BJM Pharm Inc	+86-027-5234-1919 +8613545198479	sales03@benjaminpharmchem.com	China	598	58
Jinan Dexinjia Bio&Tech Co., Ltd	+86-0531-82375818 +86-15064153060	sales@jndxj.com	China	1330	58
Hebei Chuanghai Biotechnology Co., Ltd	+8615531157085	abby@chuanghaibio.com	China	8808	58
Hebei Mujin Biotechnology Co.,Ltd	+86 13288715578 +8613288715578	sales@hbmojin.com	China	12809	58
Henan Bao Enluo International TradeCo.，LTD	+86-17331933971 +86-17331933971	deasea125996@gmail.com	China	2472	58
Henan Fengda Chemical Co., Ltd	+86-371-86557731 +86-13613820652	info@fdachem.com	China	20235	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718 +86-13336195806	sales@capot.com	China	29730	60
Shanghai Daken Advanced Materials Co.,Ltd	+86-371-+86-371-66670886	info@dakenam.com	China	19805	58

Supplier	Advantage
Blocksynth Pharmaceutical Technology Co.,Ltd	58
Zhengzhou Lingzhiyue Technology Co., Ltd	58
Wuhan BJM Pharm Inc	58
Jinan Dexinjia Bio&Tech Co., Ltd	58
Hebei Chuanghai Biotechnology Co., Ltd	58
Hebei Mujin Biotechnology Co.,Ltd	58
Henan Bao Enluo International TradeCo.，LTD	58
Henan Fengda Chemical Co., Ltd	58
Capot Chemical Co.,Ltd.	60
Shanghai Daken Advanced Materials Co.,Ltd	58

View Lastest Price from 2-Amino-4-chloropyridine manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2025-04-25	2-Amino-4-chloropyridine 19798-80-2	US $0.00-0.00 / Kg/Drum	1KG	98%min	500KGS	WUHAN FORTUNA CHEMICAL CO., LTD
2025-04-23	2-Amino-4-chloropyridine 19798-80-2	US $10.00 / KG	1KG	99%	10 mt	Hebei Chuanghai Biotechnology Co., Ltd
2025-04-04	2-Amino-4-chloropyridine 19798-80-2	US $0.00-0.00 / KG	1KG	98%	1Ton	Henan Aochuang Chemical Co.,Ltd.

2-Amino-4-chloropyridine
19798-80-2
US $0.00-0.00 / Kg/Drum
98%min
WUHAN FORTUNA CHEMICAL CO., LTD

2-Amino-4-chloropyridine
19798-80-2
US $10.00 / KG
99%
Hebei Chuanghai Biotechnology Co., Ltd

2-Amino-4-chloropyridine
19798-80-2
US $0.00-0.00 / KG
98%
Henan Aochuang Chemical Co.,Ltd.

2-Amino-4-chloropyridine Spectrum

2-Amino-4-chloropyridine(19798-80-2)¹HNMR 2-Amino-4-chloropyridine(19798-80-2)FT-IR

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4-Chloro-2-aminopyridine 2-Pyridinamine,4-chloro-(9CI) cas:19798-80-2 2-Pyridinamine, 4-chloro- 2-AMINO-4-CHLOROPYRIDINE,4-CHLORO-PYRIDIN-2-YLAMINE 4-CHLORO-PYRIDIN-2-YLAMINE,97% 4-Chloro-2-amine-pyridin 2-Amino-4-chloropyridine ,98% 4-Chloropyridine-2-amine 2-Amino-4-Cholropyridine 4-Chloropyrid-2-ylaMine l (4-Chloropyridin-2-yl)aMine 2-AMino-4-chloropyridine CAS 19798-80-2 2-AMino-4-chloropyridine 97% 2- aMino-4- chlorinepyridine 2-AMINO-4-CHLOROPYRIDINE 4-CHLORO-PYRIDIN-2-YLAMINE 4-CHLORO-2-PYRIDINYLAMINE IFLAB-BB F1926-0004 2-Amino-4-chloropyridine ISO 9001：2015 REACH DK765 4-chloro-2-pyridinamine 4-CHLOROPYRIDIN-2-AMINE 4-CHLORO-PYRIDINE-2-YLAMINE 19798-80-2 19792-80-2 9798-80-2 1970.98-80-2 C5H6ClN2 Building Blocks Pyridines Heterocyclic Building Blocks Halogenated Heterocycles Pyridines, Pyrimidines, Purines and Pteredines Heterocyclic Series Amines and Anilines Heterocycles Amino-pyridine series Nucleotides and Nucleosides Bases & Related Reagents Nucleotides Pharmaceutical intermediate pharmacetical Pyridine series Amines OLED materials,pharm chemical,electronic Aromatics Building Blocks C5 C5 to C6 Chemical Synthesis Halogenated Heterocycles Heterocyclic Building Blocks PYRIDINE blocks Pyridines bc0001