Chinese Japanese Germany Korea
ChemicalBook >> CAS DataBase List >>NOMIFENSINE MALEATE SALT

NOMIFENSINE MALEATE SALT

NOMIFENSINE MALEATE SALT Structure
NOMIFENSINE MALEATE SALT structure
CAS No.
32795-47-4
Chemical Name:
NOMIFENSINE MALEATE SALT
Synonyms
hoe984;Alival;merital;meritalam;hostalival;NSC-289114;NOMIFENSINE MALEATE;alival(antidepressant);(±)-Nomifensine maleat;NOMIFENSINE MALEATE SALT
CBNumber:
CB7202667
Molecular Formula:
C16H18N2.C4H4O4
Molecular Weight:
354.4
MDL Number:
MFCD00069320
MOL File:
32795-47-4.mol
Last updated:2024-11-19 23:02:33
Request For Quotation

NOMIFENSINE MALEATE SALT Properties

Melting point 199-201°
storage temp. Refrigerator, Under Inert Atmosphere
solubility DMSO (Slightly), Methanol (Slightly, Heated)
form Solid
color Crystals from EtOH
Water Solubility Water : 2.2 mg/mL (6.21 mM; Need ultrasonic)
FDA UNII 76S8CUH5MR

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P264-P270-P301+P312-P302+P352-P305+P351+P338
Hazard Codes  Xn
Risk Statements  22-36/37/38
Safety Statements  26-36
RIDADR  3249
WGK Germany  3
RTECS  NX4912800
HazardClass  6.1(b)
PackingGroup  III
Toxicity LD50 in mice, rats (mg/kg): 400, 430 orally; 90, 72 i.v.; in mice (mg/kg): 410 s.c. (Hoffman, 1973)

NOMIFENSINE MALEATE SALT price More Price(18)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich N1530 Nomifensine maleate salt 32795-47-4 100mg $297 2024-03-01 Buy
TRC N635950 NomifensineMaleicAcidSalt 32795-47-4 5g $1395 2021-12-16 Buy
TRC N635950 NomifensineMaleicAcidSalt 32795-47-4 100mg $160 2021-12-16 Buy
ChemScene CS-4709 Nomifensinemaleate 99.67% 32795-47-4 100mg $192 2021-12-16 Buy
ApexBio Technology B6911 Nomifensine 32795-47-4 100mg $240 2021-12-16 Buy
Product number Packaging Price Buy
N1530 100mg $297 Buy
N635950 5g $1395 Buy
N635950 100mg $160 Buy
CS-4709 100mg $192 Buy
B6911 100mg $240 Buy

NOMIFENSINE MALEATE SALT Chemical Properties,Uses,Production

Chemical Properties

Pale Yellow Solid

Originator

Alival,Hoechst,W. Germany ,1976

Uses

A novel antidepressant distinguished from existing tricyclic and tetracyclic antidepressants by its bicyclic structure.

Uses

Antidepressant;Dopamine uptake inhibitor

Uses

Nomifensine maleate salt has been used to study the β-CFT (cocaine analogue) binding using human embryonic kidney 293T cells.

Manufacturing Process

A solution of N-(2-aminobenzyl)-1-phenyl-2-methylaminoethanol-1 was prepared by the reaction of α-bromo-acetophenone and (2nitrobenzyl)methylamine, followed by hydrogenation of the nitro group by means of nickel on diatomaceous earth at room temperature and reduction of the CO group by means of sodium borohydride. The intermediate thus produced was dissolved in 100 ml of methylene chloride and introduced dropwise into 125 ml of sulfuric acid at 10° to 15°C. After a short standing, the reaction mixture was poured onto ice and rendered alkaline by means of a sodium hydroxide solution. By extraction with ether, there was obtained 1,2,3,4-tetrahydro-2-methyl-4-phenyl-8-amino-isoquinoline. The base is reacted with maleic acid to give the maleate; melting point of the maleate 199° to 201°C (from ethanol).

brand name

Merital (Hoechst-Roussel).

Therapeutic Function

Psychostimulant

Biochem/physiol Actions

Nomifensine maleate is a selective dopamine uptake inhibitor interacting with the dopamine transporter, at a site different from that of cocaine; antidepressant. Nomifensine serves as an antidepressant and is known to cause frequent hemolytic anemia. The aniline group in this compound results in blood and liver toxicities.

Safety Profile

Poison by ingestion,subcutaneous, intravenous, and intraperitoneal routes.Human systemic effects by intravenous route: heart ratechanges, blood pressure elevation. Experimentalreproductive effects. An antidepressant. When heated to decomposition it em

storage

Store at +4°C

NOMIFENSINE MALEATE SALT Preparation Products And Raw materials

Raw materials

Sulfuric acid Hydrogen Sodium borohydride Maleic acid

Preparation Products

NOMIFENSINE MALEATE SALT Suppliers

Global( 68)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 32957 60
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32165 58
Dideu Industries Group Limited 		+86-29-89586680 +86-15129568250 1026@dideu.com China 22783 58
Zhejiang J&C Biological Technology Co.,Limited 		+1-2135480471 +1-2135480471 sales@sarms4muscle.com China 10473 58
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6391 58
TargetMol Chemicals Inc. 		support@targetmol.com United States 38632 58
LEAPCHEM CO., LTD. 		+86-852-30606658 market18@leapchem.com China 43340 58
Shanghai Acmec Biochemical Technology Co., Ltd. 		+undefined18621343501 product@acmec-e.com China 33338 58
Aladdin Scientific 		+1-+1(833)-552-7181 sales@aladdinsci.com United States 57505 58
SHANGHAI KEAN TECHNOLOGY CO., LTD. 		+8613817748580 cooperation@kean-chem.com China 40066 58
Supplier Advantage
ATK CHEMICAL COMPANY LIMITED 		60
TargetMol Chemicals Inc. 		58
Dideu Industries Group Limited 		58
Zhejiang J&C Biological Technology Co.,Limited 		58
InvivoChem 		58
TargetMol Chemicals Inc. 		58
LEAPCHEM CO., LTD. 		58
Shanghai Acmec Biochemical Technology Co., Ltd. 		58
Aladdin Scientific 		58
SHANGHAI KEAN TECHNOLOGY CO., LTD. 		58

View Lastest Price from NOMIFENSINE MALEATE SALT manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Nomifensine maleate pictures 2024-11-19 Nomifensine maleate
32795-47-4
 US $37.00-87.00 / mg 98.46% 10g TargetMol Chemicals Inc.
NOMIFENSINE MALEATE SALT USP/EP/BP pictures 2021-07-27 NOMIFENSINE MALEATE SALT USP/EP/BP
32795-47-4
 US $1.10 / g 1g 99.9% 100 Tons min Dideu Industries Group Limited

NOMIFENSINE MALEATE SALT Spectrum

NOMIFENSINE MALEATE SALT(32795-47-4)MS

32795-47-4(NOMIFENSINE MALEATE SALT)Related Search:

NOMIFENSINE MALEATE Chlorphenamine maleate MALEIC ACID MONOSODIUM SALT PHENRAMINE MALEATE N-(5-Chloro-2-pyridinyl)-2-[[4-[(dimethylamino)iminomethyl]benzoyl]amino]-5-methoxybenzamide (2Z)-2-butenedioate (1:1)
Ammonium hydrogen maleate 2-DIMETHYLAMINOMETHYL-ANILINE 4-phenyl-1,2,3,4-tetrahydroisoquinoline NOMIFENSINE MALEATE SALT

1of2

1,2,3,4-tetrahydro-2-methyl-4-phenyl-8-isoquinolinamin(z)-2-butenedioate 1,2,3,4-tetrahydro-8-amino-2-methyl-4-phenyl-isoquinolinmaleate 8-amino-2-methyl-4-phenyl-1,2,3,4-tetrahydroisoquinolinemaleate alival(antidepressant) hoe984 hostalival merital meritalam nomifensinehydrogenmaleate nomifensinhydrogenmaleate NOMIFENSINE MALEATE NOMIFENSINE MALEATE SALT 8-ammonio-1,2,3,4-tetrahydro-2-methyl-4-phenylisoquinolinium maleate Alival NSC-289114 1,2,3,4-TETRAHYDRO-2-METHYL-4-PHENYL-8-ISOQUINOLINAMINE MALEATE SALT 2-methyl-4-phenyl-1,2,3,4-tetrahydroisoquinolin-2-ium-8-amine 1,2,3,4-Tetrahydro-2-methyl-4-phenyl-8-isoquinolinamine maleate (±)-Nomifensine maleat Nomifensine Maleic Acid Salt NOMIFENSINE MALEATE SALT USP/EP/BP 2-Methyl-4-phenyl-1,2,3,4-tetrahydroisoquinolin-8-amine maleate Dopamine Receptor,inhibit,Inhibitor,Nomifensine maleate,Nomifensine 8-Isoquinolinamine, 1,2,3,4-tetrahydro-2-methyl-4-phenyl-, (2Z)-2-butenedioate (1:1) 32795-47-4 C16H18N2C4H4O4 Inhibitors API Heterocycles series