Epipodophyllotoxin
- CAS No.
- 4375-07-9
- Chemical Name:
- Epipodophyllotoxin
- Synonyms
- Eipodophyllotoxin;Epipodophyllotoxin;(-)-Epipodophyllotoxin;Podophyllotoxin 9-Epimer;(5R)-5,8,8aβ,9-Tetrahydro-9α-hydroxy-5β-(3,4,5-trimethoxyphenyl)furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxole-(5aαH)-one;(5R)-5,5aα,8aβ,9-Tetrahydro-9α-hydroxy-5β-(3,4,5-trimethoxyphenyl)furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxole-6(8H)-one;(5S,5aR,8aR,9R)-5-hydroxy-9-(3,4,5-trimethoxyphenyl)-5a,6,8a,9-tetrahydro-5H-isobenzofuro[5,6-f][1,3]benzodioxol-8-one;(5S,5aR,8aR,9R)-5-hydroxy-9-(3,4,5-trimethoxyphenyl)-5a,6,8a,9-tetrahydro-5H-[2]benzofuro[5,6-f][1,3]benzodioxol-8-one;(5R,5aR,8aR,9S)-5,8,8a,9-Tetrahydro-5-(3,4,5-trimethoxyphenyl)-9-hydroxyfuro[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one;(5R,5aR,8aR,9S)-9-Hydroxy-5-(3,4,5-trimethoxyphenyl)-5,8,8a,9-tetrahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6(5aH)-one
- CBNumber:
- CB72177765
- Molecular Formula:
- C22H22O8
- Molecular Weight:
- 414.41
- MDL Number:
- MFCD01725610
- MOL File:
- 4375-07-9.mol
| Melting point | 160.3°C |
|---|---|
| Boiling point | 453.31°C (rough estimate) |
| Density | 1.2649 (rough estimate) |
| refractive index | 1.4480 (estimate) |
| storage temp. | Hygroscopic, -20°C Freezer, Under inert atmosphere |
| solubility | Chloroform (Slightly), Methanol (Slightly) |
| form | Solid |
| pka | 13.26±0.40(Predicted) |
| color | White to Off-White |
| Stability | Hygroscopic |
| NCI Dictionary of Cancer Terms | epipodophyllotoxin |
Epipodophyllotoxin price More Price(4)
Epipodophyllotoxin Chemical Properties,Uses,Production
Uses
Epipodophyllotoxins is a naturally occuring antitumors agent extracted from Mayapple plant.
Mechanism of action
Epipodophyllotoxin is a highly effective anticancer drug. Its mechanism of action may be to inhibit topoisomerase II, which in turn prevents the replication of DNA in tumour cells.
Anticancer Research
It is a lignan compound; podophyllotoxin is isolated from the roots of Podophyllumpeltatum and P. emodi. Teniposide and etoposide are the semisynthetic derivativesof epipodophyllotoxin, and they are used for lymphomas and bronchial and testicularcancers (Shoeb 2006). These compounds break DNA molecules during the G2/Mphase in cell cycle by binding to tubulin and irreversibly inhibiting DNAtopoisomerase II (Balunas and Kinghorn 2005). Podophyllotoxin prevents thebreast cancer cell growth by modifying checkpoint kinase 2 (Chk2) signalingpathway and also induces apoptosis in non-small cell lung cancer by cell cyclearrest, autophagy, and ER stress (Singh et al. 2016b).
Epipodophyllotoxin Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Zheyan Biotech Co., Ltd. | 18017610038 | zheyansh@163.com | CHINA | 3619 | 58 |
| Chengdu Biopurify Phytochemicals Ltd. | +86-28-82633860; +8618080483897 | sales@biopurify.com | China | 3772 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | +86-0571-88938639 +8617705817739 | info@dycnchem.com | China | 52849 | 58 |
| Henan Alfa Chemical Co., Ltd | +8615838112936 | alfa10@alfachem.cn | China | 13194 | 58 |
| TargetMol Chemicals Inc. | support@targetmol.com | United States | 38630 | 58 | |
| PT CHEM GROUP LIMITED | +86-85511178; +86-85511178; | peter68@ptchemgroup.com | China | 35425 | 58 |
| GIHI CHEMICALS CO.,LIMITED | +8618058761490 | info@gihichemicals.com | China | 49984 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 52924 | 58 | |
| Mensura Group Limited | +8618109034517 | 1058503172@qq.com | China | 2900 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |