Lornoxicam | 70374-39-9

Lornoxicam Properties

Melting point	225-230°C (dec.)
Density	1.742±0.06 g/cm3(Predicted)
storage temp.	Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility	DMSO: >5mg/mL (warmed)
pka	pKa2 4.7(at 25℃)
form	powder
color	faint yellow to dark yellow
Merck	14,5582
InChI	InChI=1S/C13H10ClN3O4S2/c1-17-10(13(19)16-9-4-2-3-5-15-9)11(18)12-7(23(17,20)21)6-8(14)22-12/h2-6,18H,1H3,(H,15,16,19)
InChIKey	WLHQHAUOOXYABV-UHFFFAOYSA-N
SMILES	S1(=O)(=O)C2C=C(Cl)SC=2C(O)=C(C(NC2=NC=CC=C2)=O)N1C
CAS DataBase Reference	70374-39-9(CAS DataBase Reference)
FDA UNII	ER09126G7A
ATC code	M01AC05

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS06

Signal word

Danger

Hazard statements

H300

Precautionary statements

Hazard Codes

Risk Statements

Safety Statements

RIDADR

UN 2811 6.1 / PGII

WGK Germany

3

RTECS

XJ9095000

HazardClass

IRRITANT

PackingGroup

II

HS Code

29349990

Toxicity

LD50 orally in mice, rats, rabbits, dogs, monkeys: >10 mg/kg (Pruss)

NFPA 704

	0
4		0

Lornoxicam price More Price(34)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	SML0338	Lornoxicam ≥98% (HPLC)	70374-39-9	10mg	$96.7	2024-03-01	Buy
Sigma-Aldrich	SML0338	Lornoxicam ≥98% (HPLC)	70374-39-9	50mg	$314	2024-03-01	Buy
TCI Chemical	L0239	Lornoxicam >98.0%(HPLC)(N)	70374-39-9	1g	$135	2024-03-01	Buy
TCI Chemical	L0239	Lornoxicam >98.0%(HPLC)(N)	70374-39-9	5g	$404	2024-03-01	Buy
Cayman Chemical	70220	Lornoxicam ≥98%	70374-39-9	50mg	$57	2024-03-01	Buy

Product number	Packaging	Price	Buy
SML0338	10mg	$96.7	Buy
SML0338	50mg	$314	Buy
L0239	1g	$135	Buy
L0239	5g	$404	Buy
70220	50mg	$57	Buy

Lornoxicam Chemical Properties,Uses,Production

Description

Lornoxicam (Trade name: “Xefo”) belongs to a non-steroidal anti-inflammatory drug. As a kind of oxicam class drug, it has analgesic, anti-inflammatory and antipyretic properties. It can be used for the treatment of various type of acute mild to moderate pain which results from inflammatory diseases of the joints, osteoarthritis, surgery, sciatica and rheumatic diseases. Lornoxicam is capable of potently inhibiting the prostaglandin biosynthesis process, making it have highly pronounced efficacy. The exact mechanism of Lornoxicam is not exactly understood. However, it is indicated that Lornoxicam can inhibit the prostaglandin and thromboxane synthesis by inhibiting both COX-1 and COX-2, leading to reduction of inflammation, pain, fever, and swelling.

References

https://www.drugbank.ca/drugs/DB06725
https://en.wikipedia.org/wiki/Lornoxicam

Description

Lornoxicam is a COX inhibitor and non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory and analgesic properties. It inhibits production of thromboxane B₂ (TXB₂; ) from arachidonic acid (Item Nos. 90010 | 90010.1 | 10006607) in HEL human erythroleukemic cells (IC₅₀ = 3 nM), which endogenously express COX-1, as well as inhibits LPS-induced formation of prostaglandin F_1α (PGF_1α; ) from arachidonic acid in Mono-Mac-6 cells (IC₅₀ = 8 nM), which endogenously express COX-2. Lornoxicam reduces LPS-induced production of nitric oxide and IL-6 in cell-based assays with IC₅₀ values of 65 and 54 μM, respectively. It reduces carrageenan-induced paw edema in rats when administered intravenously at doses ranging from 0.1 to 9 mg/kg. Formulations containing lornoxicam have been used in the management of postoperative pain.

Description

Lornoxicam is a nonselective NSAID for oral and intravenous administration. It has been available for human use since two decades and there is a growing body of evidence supporting its efficacy and tolerability for management of acute pain.
Xefo, a member of the oxicam family of nonsteroidal antiinflammatory agents, was launched in Denmark for mild to moderate pain and inflammation. A seven step synthesis, beginning with 2,5-dichlorothiophene, provides access to this compound. It inhibits prostaglandin synthesis at the level of cyclooxygenase (Cox1 :Cox2 = 0.6) but does not inhibit 5-lipoxygenase. Xefo did not increase serum levels of pepsinogen I (an indicator of gastric mucosal status) and readily penetrates perivascular interstitial spaces including synovial fluid. It is as effective as morphine, meperidine and tramadol in relieving post operative pain and as efficient as other NSAlDs in relieving the symptoms of osteoarthritis and rheumatoid arthritis. It is 100 times more potent than Tenoxicam in inhibiting PGD2 and more active than indomethacin (6x) or piroxicam (10x) in preventing arachadonic acid influenced lethality in mice. Xefo has inhibitor effects on spinal nocicceptive processing presumably via release of endogenous opiods and evidence suggests it is good for migraine.

Chemical Properties

Crystalline Solid

Originator

Nycomed Amersham (Norway)

Uses

For the treatment of acute mild to moderate pain, as well as pain and inflammation of the joints caused by certain types of rheumatic diseases.

Uses

keratolytic, antiacne, antineoplastic

Uses

Cyclooxygenase inhibitor; structurally similar to tenoxicam. Anti-inflammatory; analgesic

Uses

Lornoxicam belongs to the oxicam class. It has anti-inflammatory and antipyretic properties. Lornoxicam prevents the synthesis of prostaglandin (PG) by inhibiting cyclo-oxygenase. It is used to relieve various types of symptoms associated with osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, acute sciatica and low back pain.Lornoxicam is approved for use in Japan.
Lornoxicam has been used as a drug in melanin binding study with cassette dosing and rapid equilibrium dialysis inserts. Lornoxicam differs from other oxicam compounds in its potent inhibition of prostaglandin biosynthesis, a property that explains the particularly pronounced efficacy of the drug.

Indications

Lornoxicam is a non-steroidal anti-inflammatory drug (NSAID) that is used as a painkiller (analgesic). A high level of pain relief is experienced by about 45% of those with moderate to severe postoperative dental pain after a single dose of lornoxicam 8 mg, compared to about 10% with placebo. This is comparable to the proportion experiencing the same level of pain relief with ibuprofen 200 to 400 mg. Adverse events were generally mild and did not differ from placebo in these singe dose studies. There were insufficient data to assess duration of action, but it is likely to be similar to ibuprofen 200 mg.

Definition

ChEBI: A thienothiazine-derived monocarboxylic acid amide obtained by formal condensation of the carboxy group of 6-chloro-4-hydroxy-2-methylthieno[2,3-e][1,2]thiazine-3-carboxylic acid 1,1-dioxide with the amino group of 2-aminopyridine. Used for th treatment of pain, primarily resulting from inflammatory diseases of the joints, osteoarthritis, surgery, sciatica and other inflammations.

brand name

Xefo

in vitro

studies on intact human cells showed that lornoxicam intensively inhibit cox-1 and cox-2 with the lowest ic50 among a large panel of nsaids tested. similar findings were obtained in the whole blood for cox-1/-2. in addition lornoxicam suppressed no formation in a dose-dependently manner with an ic50 of 65 μm. [2]

in vivo

in vivo studies found that lornoxicam was as effective as comparative nsaids and that 8 mg lornoxicam was more effective than 10 mg morphine as a pain-reliever after oral surgery. orally administration of lornoxicam at 16-24 mg daily was more effective than tramadol at 300 mg daily in pain-alleviating after knee surgery. compared to naproxen, lornoxicam showed higher therapeutic potency and lower gastrointestinal toxicity. this was probably due to the short half-life of lornoxicam as compared to the other oxicams. [3]

IC 50

a potent cox-1 and cox-2 inhibitor with ic50 values of 5 nm and 8 nm, respectively.

References

[1]balfour ja, fitton a and barradell lb. lornoxicam, a review of its pharmacology and therapeutic potential in the management of painful and inflammatory conditions. drugs. 1996 apr; 51(4): 639-57.
[2]berg j, fellier h, christoph t, grarup j and stimmeder d. the analgesic nsaid lornoxicam inhibits cyclooxygenase (cox)-1/-2, inducible nitric oxide synthase (inos), and the formation of interleukin (il)-6 in vitro. inflamm res. 1999 jul; 48(7): 369-79.
[3]radhofer-welte s and rabasseda x. lornoxicam, a new potent nsaid with an improved tolerability profile. drugs today (barc). 2000 jan; 36(1): 55-76.
[4]sharma a, pingle a, and baliga vp. lornoxicam efficacy in acute pain (leap) trial. j indian med assoc. 2008 dec; 106(12): 811-3.

Lornoxicam synthesis

Synthesis of Lornoxicam from 2-Aminopyridine

Lornoxicam Preparation Products And Raw materials

Raw materials

Sodium hydride 2,5-Dichlorothiophene Iodoacetic acid thiazine Chlorosulfonic acid

Phosphorus pentachloride 2-Aminopyridine Methyl acetate n-Butyllithium

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Preparation Products

Lornoxicam Suppliers

Global( 569)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Hebei Weibang Biotechnology Co., Ltd	+8615531157085	abby@weibangbio.com	China	8812	58
Hebei Chuanghai Biotechnology Co,.LTD	+86-13131129325	sales1@chuanghaibio.com	China	5893	58
Hebei Jingbo New Material Technology Co., Ltd	+8619931165850	hbjbtech@163.com	China	1000	58
Hebei Saisier Technology Co., LTD	+86-18400010335 +86-18034520335	admin@hbsaisier.cn	China	1015	58
Hebei Longbang Technology Co., LTD	+86-18633929156 +86-18633929156	admin@hblongbang.com	China	941	58
Hebei Ganmiao New material Technology Co., LTD	+86-17332992504 +86-17332992504	sales8@hbganmiao.com	China	299	58
BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.	+86-18600796368 +86-18600796368	sales@sjar-tech.com	China	444	58
HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD	+86-15350851019 +86-15383190639	admin@86-ss.com	China	1000	58
Beijing Cooperate Pharmaceutical Co.,Ltd	010-60279497	sales01@cooperate-pharm.com	CHINA	1803	55
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21634	55

Supplier	Advantage
Hebei Weibang Biotechnology Co., Ltd	58
Hebei Chuanghai Biotechnology Co,.LTD	58
Hebei Jingbo New Material Technology Co., Ltd	58
Hebei Saisier Technology Co., LTD	58
Hebei Longbang Technology Co., LTD	58
Hebei Ganmiao New material Technology Co., LTD	58
BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.	58
HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD	58
Beijing Cooperate Pharmaceutical Co.,Ltd	55
Henan Tianfu Chemical Co.,Ltd.	55

View Lastest Price from Lornoxicam manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-11-24	Lornoxicam 70374-39-9	US $999.00-666.00 / kg	1kg	99%	5000	HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD
2024-11-22	Lornoxicam 70374-39-9	US $0.00 / Kg/Bag	1KG	98%min	25kg	WUHAN FORTUNA CHEMICAL CO., LTD
2024-11-22	Lornoxicam 70374-39-9	US $6.00 / kg	1kg	99%	2000KG/Month	HebeiShuoshengImportandExportco.,Ltd

Lornoxicam
70374-39-9
US $999.00-666.00 / kg
99%
HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD

Lornoxicam
70374-39-9
US $0.00 / Kg/Bag
98%min
WUHAN FORTUNA CHEMICAL CO., LTD

Lornoxicam
70374-39-9
US $6.00 / kg
99%
HebeiShuoshengImportandExportco.,Ltd

Lornoxicam Spectrum

Lornoxicam(70374-39-9)¹HNMR

70374-39-9(Lornoxicam)Related Search:

4-Dimethylaminopyridine Basic Violet 1 4,5,6,7-Tetrahydrothieno[3,2-c]pyridine 2-Hydroxypyridine 3-Aminopyridine

Methyl salicylate CHLOROPHOSPHONAZO III Tribenuron methyl Kresoxim-methyl Methylparaben

Methanol 2-Aminopyridine Methyl acrylate 5-HYDROXY LORNOXICAM Methyl

6-Chloro-4-hydroxy-2-methyl-2H-thieno[2,3-e]-1,2-thiazine-3-carboxylic acid methyl ester 1,1-dioxide (Lornoxicam),LORNOXICAM INTERMEDIATE 5-Chloro-3-(N-methylsulfamoyl)-thiophene-2-carboxylic acid methyl ester (Lornoxicam) 5-Chloro-3-[N-(methoxy-carbonyl-methyl)sulfamoyl]-2-thiophene carboxylic acid methyl ester (Lornoxicam)

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LORNOXICAM AKOS 93662 6-Chloro-4-hydroxy-2-methyl-N-(2-pyridyl)-2H-thieno[2,3-e][1,2]thiazine-3-carboxamide 1,1-dioxide LornoxicaM for injection 6-Chloro-4-hydroxy-2-Methyl-N-2-pyridinyl- LornoxicaM API 6-Chloro-4-hydroxy-2-Methyl-N-pyridin-2-yl-2H-thieno[2,3-e][1,2]thiazine-3-carboxaMide LornoxicaM (Xefo) 6-Chloro-4-hydroxy-2-methyl-N-pyridin-2-yl-2H-thie no[2,3-e][1,2]thiazine-3-carboxamide 1,1-dioxi 1,1-dioxide-6-chloro-4-hydroxy-2-methyl-N-2-pyridinyl-2H-thieno[2,3-e]-1,2-thiazine-3-carboxamide 6-Chloro-4-hydroxy-2-methyl-N-pyridin-2-yl-2H-thieno[2,3-e][1,2]thiazine-3-carboxamide 1,1-dio 6-CHLORO-4-HYDROXY-2-METHYL-N-2-PYRIDINYL-2H-THIENO[2,3-E]-1,2-THIAZINE-3-CARBOXAMIDE 1,1-DIOXIDE 2h-thieno(2,3-e)-1,2-thiazine-3-carboxamide,6-chloro-4-hydroxy-2-methyl-n-2-py chlortenoxicam ridinyl-,1,1-dioxide 6-Chloro-4-hydroxy-2-methyl-N-pyridin-2-yl-2H-thieno[2,3-e][1,2]thiazine-3-carboxamide-1,1-dioxide LornoxicamConsultedStandard Ro 13-9297 Telos TS 110 Xefo Xefocam 6-Chloro-4-hydroxy-2-methyl-N-2-pyridinyl-2H-thieno[2,3-e]-1，2-thiazine-3-carboxamidel，1-dioxide Lornoxicam, 98%, a non-steroidal COX-1/COX-2 inhibitor (3Z)-6-chloro-3-[hydroxy-(2-pyridinylamino)methylidene]-2-methyl-1,1-dioxo-4-thieno[2,3-e]thiazinone Lornoxicam> ornoxicam 6-chloro-4-hydroxy-2-methyl-1,1-dioxo-N-(pyridin-2-yl)-2H-1$l^{6},5,2-thieno[2,3-e][1$l^{6},2]thiazine-3-carboxamide 2H-Thieno[2,3-e]-1,2-thiazine-3-carboxamide, 6-chloro-4-hydroxy-2-methyl-N-2-pyridinyl-, 1,1-dioxide Lornoxicam USP/EP/BP Lornoxicam (Chlortenoxicam LornoxicamQ: What is Lornoxicam Q: What is the CAS Number of Lornoxicam Q: What is the storage condition of Lornoxicam Q: What are the applications of Lornoxicam 6-Chloro-4-hydroxy-2-methyl-N-pyridin-2-yl-2H-thieno[2,3-e][1,2]thiazine-3-carboxamide 1,1-dioxide (Lornoxicam) Lornoxicam Impurity 33 Yesterday, the chlorine methyl 5-chloro-3-(ethoxysulfonyl)thiophene-2-carboxylate Lornoxicam INH Lornoxicam, ≥ 98.0% Ro 13-9297|||Chlortenoxicam|||TS110 70374-39-9 原料药 > 解热镇痛药 > 非甾抗炎药 > 氯诺昔康 C13H10ClN3O4S2 Sulfur & Selenium Compounds Pharmaceuticals Intermediates & Fine Chemicals Inhibitors APIs Fused Ring Systems API Other APIs AVITA 70374-39-9