ChemicalBook >> CAS DataBase List >>(22R,23R,25R)-5β,6β-Epoxy-4β,16β,20,22,23-pentahydroxy-1-oxoergost-2-en-26-oic acid γ-lactone
(22R,23R,25R)-5β,6β-Epoxy-4β,16β,20,22,23-pentahydroxy-1-oxoergost-2-en-26-oic acid γ-lactone
- CAS No.
- 71801-45-1
- Chemical Name:
- (22R,23R,25R)-5β,6β-Epoxy-4β,16β,20,22,23-pentahydroxy-1-oxoergost-2-en-26-oic acid γ-lactone
- Synonyms
- Ixocarpalactone A;(22R,23R,25R)-5β,6β-Epoxy-4β,16β,20,22,23-pentahydroxy-1-oxoergost-2-en-26-oic acid γ-lactone;Ergost-2-en-26-oic acid, 5,6-epoxy-4,16,20,22,23-pentahydroxy-1-oxo-, γ-lactone, (4β,5β,6β,16β,22R,23R,25R)-
- CBNumber:
- CB72287404
- Molecular Formula:
- C28H40O8
- Molecular Weight:
- 504.62
- MDL Number:
- MOL File:
- 71801-45-1.mol
Last updated:2023-05-04 17:34:41
(22R,23R,25R)-5β,6β-Epoxy-4β,16β,20,22,23-pentahydroxy-1-oxoergost-2-en-26-oic acid γ-lactone Chemical Properties,Uses,Production
Definition
ChEBI: Ixocarpalactone A is a withanolide.
Anticancer Research
This terpenoid compound is isolated from the edible plant Physalis philadelphica.The leaf and stem extract induces quinine reductase, a phase II enzyme, needed formetabolism of chemical carcinogens. The anticancer activity of ixocarpalactone isexerted through G2/M phase arrest in cell cycle, downregulation of E2F-1, DP-1,upregulation of hyper-phosphorylated retinoblastoma, and induction of apoptosis inSW480 human colon cancer cells (Balunas and Kinghorn 2005; Choi et al. 2006).
(22R,23R,25R)-5β,6β-Epoxy-4β,16β,20,22,23-pentahydroxy-1-oxoergost-2-en-26-oic acid γ-lactone Preparation Products And Raw materials
Raw materials
Preparation Products
(22R,23R,25R)-5β,6β-Epoxy-4β,16β,20,22,23-pentahydroxy-1-oxoergost-2-en-26-oic acid γ-lactone
Ixocarpalactone A
Ergost-2-en-26-oic acid, 5,6-epoxy-4,16,20,22,23-pentahydroxy-1-oxo-, γ-lactone, (4β,5β,6β,16β,22R,23R,25R)-
71801-45-1