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Ethyl 4-piperidinecarboxylate

Ethyl 4-piperidinecarboxylate structure

CAS No.: 1126-09-6

Chemical Name:: Ethyl 4-piperidinecarboxylate

Synonyms: ETHYL PIPERIDINE-4-CARBOXYLATE;ETHYL ISONIPECOTATE;4-piperidinecarboxylate;PIPERIDINE-4-CARBOXYLIC ACID ETHYL ESTER;H-Nip-OEt;H-DL-Inp-OEt;AKOS MSC-0737;RARECHEM AH CK 0180;TIMTEC-BB SBB004006;ETHYL ISONEPECOTATE

CBNumber:: CB7231962

Molecular Formula:: C8H15NO2

Molecular Weight:: 157.21

MDL Number:: MFCD00006003

MOL File:: 1126-09-6.mol

MSDS File:: SDS

Last updated:2025-02-10 22:08:48

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Ethyl 4-piperidinecarboxylate Properties

Boiling point	204 °C(lit.)
Density	1.02 g/mL at 25 °C(lit.)
vapor pressure	39.4Pa at 25℃
refractive index	n20/D 1.459(lit.)
Flash point	176 °F
storage temp.	Keep in dark place,Inert atmosphere,Room temperature
form	Liquid
pka	9.83±0.10(Predicted)
color	Clear colorless to slightly brown
Water Solubility	miscible
BRN	118419
LogP	1.15
CAS DataBase Reference	1126-09-6(CAS DataBase Reference)
NIST Chemistry Reference	Ethyl piperidine-4-carboxylate(1126-09-6)
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H227-H315-H319-H335

Precautionary statements

P210-P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313-P370+P378-P403+P235-P501-P210e-P261-P280a-P305+P351+P338-P405-P501a

Hazard Codes

C,Xi

Risk Statements

34-36/37/38

Safety Statements

23-24/25-36-26

RIDADR

UN2735

WGK Germany

Hazard Note

Irritant

HS Code

29333999

NFPA 704

	2
2		1

Ethyl 4-piperidinecarboxylate price More Price(27)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	E33505	Ethyl isonipecotate 98%	1126-09-6	25g	$51.3	2024-03-01	Buy
Sigma-Aldrich	E33505	Ethyl isonipecotate 98%	1126-09-6	100g	$148	2024-03-01	Buy
TCI Chemical	I0294	Ethyl 4-Piperidinecarboxylate >98.0%(GC)	1126-09-6	25mL	$36	2024-03-01	Buy
TCI Chemical	I0294	Ethyl 4-Piperidinecarboxylate >98.0%(GC)	1126-09-6	100mL	$94	2024-03-01	Buy
Alfa Aesar	B20601	Ethyl isonipecotate, 98%	1126-09-6	25g	$40.65	2024-03-01	Buy

Product number	Packaging	Price	Buy
E33505	25g	$51.3	Buy
E33505	100g	$148	Buy
I0294	25mL	$36	Buy
I0294	100mL	$94	Buy
B20601	25g	$40.65	Buy

Ethyl 4-piperidinecarboxylate Chemical Properties,Uses,Production

Chemical Properties

clear colorless to slightly brown liquid

Uses

Reactant for synthesis of:• ;SMN protein modulators1• ;β-aryl and β-amino-substituted aliphatic esters by rhodium catalyzed tandem double bond migration/conjugate addition2• ;Nitroethylenediamines by nucleophilic ring opening of nitroimidazolidinone3• ;RhoA inhibitors for cardiovascular disease therapy4• ;Saccharin derived Mannich bases as antimicrobials and antioxidants5Reactant for one-pot reductive amination and Suzuki-Miyaura cross coupling of formyl aryl and heteroaryl MIDA boronates6

Uses

It is used as a reactant for synthesis of SMN protein modulators, β-aryl and β-amino-substituted aliphatic esters by rhodium catalyzed tandem double bond migration/conjugate addition, nitroethylenediamines by nucleophilic ring opening of nitroimidazolidinone. It is also involved in the reactions of RhoA inhibitors for cardiovascular disease therapy and saccharin derived Mannich bases as antimicrobials and antioxidants. It is employed as a reactant for one-pot reductive amination and Suzuki-Miyaura cross coupling of formyl aryl and heteroaryl MIDA boronates.

Uses

Reactant for synthesis of SMN protein modulators and β-aryl and β-amino-substituted aliphatic esters by rhodium catalyzed tandem double bond migration/conjugate addition.

Synthesis Reference(s)

Tetrahedron Letters, 23, p. 193, 1982 DOI: 10.1016/S0040-4039(00)86783-0

Ethyl 4-piperidinecarboxylate synthesis

Synthesis of Ethyl 4-piperidinecarboxylate from Isonipecotic acid and Ethanol

Ethyl 4-piperidinecarboxylate Preparation Products And Raw materials

Raw materials

4-Piperidinecarboxylic acid, 1-[2-(2,4-dinitrophenoxy)-1-oxidodiazenyl]-, ethyl ester ethyl 1-acetylpiperidine-4-carboxylate Isonipecotic acid

Preparation Products

1-BOC-4-ETHYL-4-PIPERIDINECARBOXYLIC ACID ETHYL 1-(2-CHLOROACETYL)-4-PIPERIDINECARBOXYLATE (R)-3-Aminoquinuclidine dihydrochloride Ethyl 2-(4-(ethoxycarbonyl)piperidin-1-yl)-6-(trifluoromethyl)pyrimidine-4-carboxylate (R)-(-)-3-Quinuclidinol

1-(2,6-DIMETHOXYBENZYL)PIPERIDIN-4-AMINE HYDROCHLORIDE 1-(PYRIMIDIN-2-YL)PIPERIDINE-4-CARBOXYLIC ACID HYDROCHLORIDE 4-ALLYL-PIPERIDINE-1,4-DICARBOXYLIC ACID MONO-TERT-BUTYL ESTER 1-Boc-4-methylpiperidine-4-carboxylic acid 3-Quinuclidinone hydrochloride

(S)-(+)-3-Quinuclidinol Ethyl N-Boc-4-methylpiperidine-4-carboxylate (S)-3-Aminoquinuclidine dihydrochloride 3-Aminoquinuclidine dihydrochloride 1-(PYRIMIDIN-2-YL)PIPERIDINE-3-CARBOHYDRAZIDE

Ethyl 2-(4-(ethoxycarbonyl)piperidin-1-yl)pyrimidine-5-carboxylate quinuclidine-3-carboxylic acid 1-azabicyclo[2.2.1]heptane 1-BENZYL 4-ETHYL PIPERIDINE-1,4-DICARBOXYLATE (R)-3-Quinuclidinol hydrochloride

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Ethyl 4-piperidinecarboxylate Suppliers

Global( 569)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Senova Technology Co. Ltd.	+86-0755-86703119 +8618503098836	info@senovatech.com	China	351	58
Hebei Weibang Biotechnology Co., Ltd	+8615531157085	abby@weibangbio.com	China	8804	58
Shaanxi Dideu Medichem Co. Ltd	+86-29-81148696 +86-15536356810	1022@dideu.com	China	3882	58
Anhui Yiao New Material Technology Co., Ltd	+86-18033737140 +86-17354101231	sales1@hbganmiao.com	China	227	58
Henan Fengda Chemical Co., Ltd	+86-371-86557731 +86-13613820652	info@fdachem.com	China	20260	58
Moxin Chemicals	+8617320513646	mike@molcoo.com	China	9632	58
Frapp's ChemicalNFTZ Co., Ltd.	+86 (576) 8169-6106	sales@frappschem.com	China	880	50
Capot Chemical Co.,Ltd.	+86-（0）57185586718 +86-13336195806	sales@capot.com	China	29792	60
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21632	55
Shanghai Time Chemicals CO., Ltd.	+86-021-57951555 +8617317452075	jack.li@time-chemicals.com	China	1803	55

Supplier	Advantage
Senova Technology Co. Ltd.	58
Hebei Weibang Biotechnology Co., Ltd	58
Shaanxi Dideu Medichem Co. Ltd	58
Anhui Yiao New Material Technology Co., Ltd	58
Henan Fengda Chemical Co., Ltd	58
Moxin Chemicals	58
Frapp's ChemicalNFTZ Co., Ltd.	50
Capot Chemical Co.,Ltd.	60
Henan Tianfu Chemical Co.,Ltd.	55
Shanghai Time Chemicals CO., Ltd.	55

View Lastest Price from Ethyl 4-piperidinecarboxylate manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2025-02-17	Avatrombopag Impurity 46 1126-09-6	US $0.00-0.00 / mg	10mg	98%+	100000	Moxin Chemicals
2024-12-02	Ethyl 4-piperidinecarboxylate 1126-09-6	US $10.00 / KG	1KG	99%	10 mt	Hebei Weibang Biotechnology Co., Ltd
2024-07-14	Ethyl 4-piperidinecarboxylate 1126-09-6	US $0.10 / KG	1KG	98.0%	10	Shaanxi Dideu Medichem Co. Ltd

Avatrombopag Impurity 46
1126-09-6
US $0.00-0.00 / mg
98%+
Moxin Chemicals

Ethyl 4-piperidinecarboxylate
1126-09-6
US $10.00 / KG
99%
Hebei Weibang Biotechnology Co., Ltd

Ethyl 4-piperidinecarboxylate
1126-09-6
US $0.10 / KG
98.0%
Shaanxi Dideu Medichem Co. Ltd

Ethyl 4-piperidinecarboxylate Spectrum

Ethyl 4-piperidinecarboxylate(1126-09-6)MS Ethyl 4-piperidinecarboxylate(1126-09-6)¹HNMR Ethyl 4-piperidinecarboxylate(1126-09-6)¹³CNMR Ethyl 4-piperidinecarboxylate(1126-09-6)IR1 Ethyl 4-piperidinecarboxylate(1126-09-6)IR2 Ethyl 4-piperidinecarboxylate(1126-09-6)Raman

1126-09-6(Ethyl 4-piperidinecarboxylate)Related Search:

ETHYL 4-PIPERIDINECARBOXYLATE HYDROCHLORIDE,ETHYL 4-PIPERIDINECARBOXYLATE HCL Isonipecotic acid 1-PIPERIDINECARBONYL CHLORIDE 4-PIPERIDINECARBOXYLIC ACID T-BUTYL ESTER HCL Hexahydroisonicotinamide

Methyl 4-piperidinecarboxylate 4-Piperidinemethanol 4,4-Piperidinediol hydrochloride Methyl isonipecotate 1-BENZYL-3-OXO-PIPERIDINE-4-CARBOXYLIC ACID ETHYL ESTER

MEPERIDINE Ethyl 1-methyl-4-piperidinecarboxylate ETHYL 1-(2-CHLOROACETYL)-4-PIPERIDINECARBOXYLATE Ethyl 4-piperidinecarboxylate DIPHENOXYLATE HYDROCHLORIDE

MEPERIDINE HYDROCHLORIDE Ethyl 4-(ethoxycarbonyl)piperidine-1-acetate Ethyl N-benzyl-3-oxo-4-piperidine-carboxylate hydrochloride

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4-Carbethoxypiperidine ISONIPECOTINIC ACID ETHYL ESTER Ethyl isonipecotate ,97% 1-ethylpiperidine-4-carboxylate ethyl piperidin-4-carboxylate Ethyl isonipecotate, 98+% 100GR Ethyl isonipecotate, 98+% 25GR Ethyl Isonipecotate Isonipecotic Acid Ethyl Ester 4-Piperidinecarboxylic Acid Ethyl Ester Ethyl isonipecotate, 4-(Ethoxycarbonyl)piperidine 4-piperidine forMic acid ethyl ester Ethyl isonipecotate 98% Ethyl 4-Piperidinecarboxylate, 97.0% 4 - piperidine ethyl forMate Ethyl 4-piperidinecarboxylate for synthesis Ethyl 4-piperidinecarboxylate ESTER 4-Carboethoxypiperidine ISONIPECOTIC ACID ETHYL ESTER ETHYL 4-PIPERIDINECARBOXYLATE LABOTEST-BB LT00159543 4-PIPERDINECARBOXYLIC ACID, ETHYL ESTER 4-PIPERIDINECARBOXYLIC ACID ETHYL ESTER AKOS MSC-0737 RARECHEM AH CK 0180 TIMTEC-BB SBB004006 Ethyl Isonipecotate(ethyl 4-Piperidinecarboxylate) Hexahydroisonicotinic acid, ethyl ester Ethyl isonipecotate, 98+% Ethyl piperidine-4-carboxylate 97% Ethyl 4-Piperidinecarboxylate (Ethyl isonipecotate) H-DL-Inp-OEt H-Nip-OEt PIPERIDINE-4-CARBOXYLIC ACID ETHYL ESTER, ISONIPECOTINIC ACID ETHYL ESTER Isopecoticacidethylester Piperidin-4-carboxylic acid ethyl ester 4-(Ethoxycarbonyl)piperidine Ethyl piperidine-4-carboxylate ,97% Isonipecotic acid ethyl Piperidine-4-carboxylic acid ethyl Ethyl isonipcotinate Ethyl4-Piperidinecarboxylate> Avatrombopag Impurity 11 ETHYL ISONEPECOTATE Ethyl isohipecotate Piperidine-4-carboxylate, ethyl ester ETHYL ISONIPECOTATE ETHYL PIPERIDINE-4-CARBOXYLATE PIPERIDINE-4-CARBOXYLIC ACID ETHYL ESTER 4-piperidinecarboxylate 1-(1-(3-chloro-5-((4-(4-chlorothiophen-2-yl)-5-(4-cyclohexylpiperazin-1-yl)thiazol-2-yl)carbamoyl)pyridin-2-yl)piperidine-4-carbonyl) piperidine-4-carboxylic acid Avatroposide impurities17 4-Piperidinecarboxylic Acid Ethyl Ester (Ethyl isonipecotate) Ethyl 4-piperoxyformate Avatrhopal impurity 46 Avatrapa impurity 11 Impurity 15 of pentaethyl quinone hydrochloride 4-Piperidine Carboxylic Acide Ethyl Ester 1126-09-6 1123-09-6