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CAY10561

CAY10561 Structure
CAY10561 structure
CAS No.
933786-58-4
Chemical Name:
CAY10561
Synonyms
CAY10561;CAY-10561,CAY10561;CAY10561 Exclusive;YMUYGRBBEDYUOP-UHFFFAOYSA-N;PYRAZOLYLPYRROLE ERK INHIBITOR;1H-Pyrrole-2-carboxamide, N-[1-(3-chloro-4-fluorophenyl)-2-hydroxyethyl]-4-[4-(3-chlorophenyl)-1H-pyrazol-3-yl]-
CBNumber:
CB72454220
Molecular Formula:
C22H17Cl2FN4O2
Molecular Weight:
459.3
MDL Number:
MFCD10567088
MOL File:
933786-58-4.mol
Last updated:2023-05-21 10:59:17
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CAY10561 Properties

Boiling point 733.2±60.0 °C(Predicted)
Density 1.463±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMF: 2.5 mg/ml; DMSO: 1.5 mg/ml; Ethanol: 5 mg/ml; Ethanol:PBS (pH 7.2) (1:1): 0.5 mg/ml
form A crystalline solid
pka 12.89±0.50(Predicted)

CAY10561 price More Price(6)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 10010043 CAY10561 ≥98% 933786-58-4 500μg $26 2024-03-01 Buy
Cayman Chemical 10010043 CAY10561 ≥98% 933786-58-4 1mg $48 2024-03-01 Buy
Cayman Chemical 10010043 CAY10561 ≥98% 933786-58-4 5mg $195 2024-03-01 Buy
Cayman Chemical 10010043 CAY10561 ≥98% 933786-58-4 10mg $341 2024-03-01 Buy
AK Scientific 2019AH PyrazolylpyrroleERKinhibitor 933786-58-4 10mg $478 2021-12-16 Buy
Product number Packaging Price Buy
10010043 500μg $26 Buy
10010043 1mg $48 Buy
10010043 5mg $195 Buy
10010043 10mg $341 Buy
2019AH 10mg $478 Buy

CAY10561 Chemical Properties,Uses,Production

Description

The extracellular signal-regulated kinase (ERK) signal transduction pathway regulates a diverse array of cellular processes. These processes include cell survival, proliferation, motility, and differentiation and are constitutively activated in cancers involving lung, colon, pancreas, kidney, and ovary.1 CAY10561 is a potent, ATP-competitive inhibitor of ERK2 (Ki = 2 nM).2 This compound is highly selective for ERK2 compared to other kinases such as PKA (Ki = 0.39 μM) and JNK3 (Ki = 4 μM).2 CAY10561 inhibits proliferation of COLO 205 cells with an IC50 value of 0.54 μM.2

References

1. Junttila, M.R., Li, S.P., and Westermarck, J. Phosphatase-mediated crosstalk between MAPK signaling pathways in the regulation of cell survival FASEB J. 22,1-12(2008).
2. Aronov, A.M., Baker, C., Bemis, G.W., et al. Flipped out: Structure-guided of selective pyrazolylpyrrole ERK inhibitors J. Med. Chem. 50,1280-1287(2007).

CAY10561 Preparation Products And Raw materials

Raw materials

Preparation Products

CAY10561 Suppliers

Global( 8)Suppliers
Supplier Tel Email Country ProdList Advantage
Aladdin Scientific 		+1-+1(833)-552-7181 sales@aladdinsci.com United States 52927 58
BOC Sciences 16314854226 info@bocsci.com United States 9926 65
Shanghai Hongye Biotechnology Co. Ltd 400-9205774 sales@glpbio.cn China 6870 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767 sales@chemegen.com China 11289 58
TargetMol Chemicals Inc. 4008200310 marketing@tsbiochem.com China 24017 58
Shanghai Yifei Biotechnology Co. , Ltd. 021-65675885 18964387627 customer_service@efebio.com China 8740 58
Supplier Advantage
Aladdin Scientific 		58
BOC Sciences 65
Shanghai Hongye Biotechnology Co. Ltd 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 58
TargetMol Chemicals Inc. 58
Shanghai Yifei Biotechnology Co. , Ltd. 58

933786-58-4(CAY10561)Related Search:

CAY10561
PYRAZOLYLPYRROLE ERK INHIBITOR CAY10561 Exclusive CAY10561 YMUYGRBBEDYUOP-UHFFFAOYSA-N CAY-10561,CAY10561 1H-Pyrrole-2-carboxamide, N-[1-(3-chloro-4-fluorophenyl)-2-hydroxyethyl]-4-[4-(3-chlorophenyl)-1H-pyrazol-3-yl]- 933786-58-4