2-[(3-CHLOROPHENYL)METHOXY]-6-(1-PIPERAZINYL)PYRAZINE HYDROCHLORIDE
![2-[(3-CHLOROPHENYL)METHOXY]-6-(1-PIPERAZINYL)PYRAZINE HYDROCHLORIDE Structure](CAS/GIF/479683-64-2.gif)
- CAS No.
- 479683-64-2
- Chemical Name:
- 2-[(3-CHLOROPHENYL)METHOXY]-6-(1-PIPERAZINYL)PYRAZINE HYDROCHLORIDE
- Synonyms
- CS-687;CP809101;CP-809101;CP 809101;CP809101/CP-809101;CP 809101 hydrochlor;CP-809102 hydrochloride;CP 809101 HYDROCHLORIDE;Pyrazine, 2-[(3-chlorophenyl)methoxy]-6-(1-piperazinyl)-;6'-(3-Chlorobenzyloxy)-3,4,5,6-tetrahydro-2H-[1,2']bipyrazine
- CBNumber:
- CB72454336
- Molecular Formula:
- C15H17ClN4O
- Molecular Weight:
- 304.77
- MDL Number:
- MFCD10687106
- MOL File:
- 479683-64-2.mol
- MSDS File:
- SDS
| Boiling point | 486.6±45.0 °C(Predicted) |
|---|---|
| Density | 1.265±0.06 g/cm3(Predicted) |
| storage temp. | Desiccate at RT |
| solubility | DMSO |
| form | powder |
| pka | 8.24±0.10(Predicted) |
| color | white to beige |
| FDA UNII | A2EXW95647 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302 | |||||||||
| Precautionary statements | P301+P312+P330 | |||||||||
| NFPA 704 |
|
2-[(3-CHLOROPHENYL)METHOXY]-6-(1-PIPERAZINYL)PYRAZINE HYDROCHLORIDE price More Price(8)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | PZ0378 | CP-809,101 fumarate ≥98% (HPLC) | 479683-64-2 | 5mg | $83.7 | 2024-03-01 | Buy |
| Sigma-Aldrich | PZ0378 | CP-809,101 fumarate ≥98% (HPLC) | 479683-64-2 | 25mg | $202.8 | 2024-03-01 | Buy |
| Tocris | 3041 | CP809101hydrochloride ≥99%(HPLC) | 479683-64-2 | 50 | $658 | 2021-12-16 | Buy |
| Tocris | 3041 | CP809101hydrochloride ≥99%(HPLC) | 479683-64-2 | 10 | $165 | 2021-12-16 | Buy |
| Usbiological | 255040 | CP 809101 hydrochloride | 479683-64-2 | 10mg | $403 | 2021-12-16 | Buy |
2-[(3-CHLOROPHENYL)METHOXY]-6-(1-PIPERAZINYL)PYRAZINE HYDROCHLORIDE Chemical Properties,Uses,Production
Uses
CP 809101 is a potent and selective SR-2C and 5-HT2C agonist.
Biological Activity
Potent and selective 5-HT 2C receptor agonist (pEC 50 values are 9.96, 7.19 and 6.81 for human 5-HT 2C , 5-HT 2B and 5-HT 2A receptors respectively). Displays antipsychotic activity; suppresses condition avoidance responding (CAR) and inhibits PCP and amphetamine-stimulated hyperactivity in rats following subcutaneous administration.
Biochem/physiol Actions
CP-809,101 is a potent and high-affinity 5-hydroxytryptamine receptor 2C (5-HT2C) full agonist with only weaker partial agonist activity toward 5-HT2A & 5-HT2B (cellular Ca2+ mobilization EC50 in nM/efficiency = 0.11/93% and 0.06/97% with human and rat 5-HT2C, respectively; 153/67%/human 5HT2A, 65.3/57%/human 5HT2B, 119/79%/rat 5HT2A) and much reduced or little affinity toward other receptors, ion channels and uptake sites tested. CP-809,101 exhibits antipsychotic efficacy in reducing conditioned avoidance response/CAR (ED50 = 4.8 mg/kg s.c.) and locomotor activity (ED50 in mg/kg via s.c. = 2/rats, 1/mice; no effect up to 10 mg/kg in 5-HT2C-knockout mice), while oral administration is reported to suppress spontaneous and nocturnal food intake as well as fasting-induced refeeding in rats (～8% and ～24% reduction of cumulative food intake and body weight in 4 days, respectively; 30 mg/kg/day p.o.).
2-[(3-CHLOROPHENYL)METHOXY]-6-(1-PIPERAZINYL)PYRAZINE HYDROCHLORIDE Preparation Products And Raw materials
Raw materials
Preparation Products
2-[(3-CHLOROPHENYL)METHOXY]-6-(1-PIPERAZINYL)PYRAZINE HYDROCHLORIDE Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd | +86-18341751992 +86-15382112998 | 757984502@qq.com | China | 892 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131957 | 58 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 821-50328103-801 18930552037 | 3bsc@sina.com | China | 15839 | 69 |
| VDM Biochemicals | 0330-2528181 | sales@vdmbio.com | United States | 510 | 64 |
| NCE Biomedical Co.,Ltd. | 4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988 | China | 1493 | 55 | |
| Shanghai T&W Pharmaceutical Co., Ltd. | +86 21 61551611 | China | 9891 | 58 | |
| LETOPHARM LIMITED | +86-21-5821 5861 | sales@letopharm.com | China | 2384 | 58 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51456 | 80 |
| SPIRO PHARMA | eric_feng1954@126.com | China | 9248 | 55 | |
| Codow Chemical Co.,Ltd. | 18620099427 | amy@howeipharm.com | China | 17687 | 55 |