2,3-BIS(BROMOMETHYL)QUINOXALINE 1,4-DIOXIDE
- CAS No.
- 18080-67-6
- Chemical Name:
- 2,3-BIS(BROMOMETHYL)QUINOXALINE 1,4-DIOXIDE
- Synonyms
- Conoidin A;Conoidin A, 10 mM in DMSO;Peroxiredoxin Inhibitor, Conoidin A;2,3-BIS(BROMOMETHYL)QUINOXALINE 1,4-DIOXIDE;Quinoxaline, 2,3-bis(bromomethyl)-, 1,4-dioxide;2,3-bis(broMoMethyl)-1-oxoquinoxalin-1-iuM-4(1H)-olate;antioxidative,antioxidant,heart disease,Parasite,Inhibitor,Peroxiredoxin II,hyperperoxidation,Conoidin A,ischaemic,inhibit,neuroprotective
- CBNumber:
- CB72455090
- Molecular Formula:
- C10H8Br2N2O2
- Molecular Weight:
- 347.99
- MDL Number:
- MFCD00186742
- MOL File:
- 18080-67-6.mol
| Melting point | 180-190 °C (decomp) |
|---|---|
| Boiling point | 512.3±60.0 °C(Predicted) |
| Density | 1.95±0.1 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility | DMF: 25 mg/ml; DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml; DMSO: 20 mg/ml |
| form | A crystalline solid |
| pka | 1.91±0.30(Predicted) |
| color | White to yellow |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
2,3-BIS(BROMOMETHYL)QUINOXALINE 1,4-DIOXIDE price More Price(17)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 5.30746 | Peroxiredoxin Inhibitor, Conoidin A - CAS 18080-67-6 - Calbiochem | 18080-67-6 | 25mg | $264 | 2024-03-01 | Buy |
| Cayman Chemical | 15605 | Conoidin A ≥98% | 18080-67-6 | 25mg | $57 | 2024-03-01 | Buy |
| Cayman Chemical | 15605 | Conoidin A ≥98% | 18080-67-6 | 50mg | $85 | 2024-03-01 | Buy |
| Cayman Chemical | 15605 | Conoidin A ≥98% | 18080-67-6 | 100mg | $111 | 2024-03-01 | Buy |
| Cayman Chemical | 15605 | Conoidin A ≥98% | 18080-67-6 | 250mg | $249 | 2024-03-01 | Buy |
2,3-BIS(BROMOMETHYL)QUINOXALINE 1,4-DIOXIDE Chemical Properties,Uses,Production
Uses
Conoidin A is a peroxiredoxin inhibitor.
Biological Activity
Cell permeable: yes', 'Primary Target
Peroxiredoxin', 'Reversible: no', 'Target IC50: 23 μM for blocking TgPrxII hyperperoxidation activity
in vivo
Conoidin A (intraperitoneal injection; 5 mg/kg; for three successive days before MI/R injury) blocks the effect of Luteolin (HY-N0162) on the ST-segment elevation. Furthermore, an increase in the infarct size presented of the MI/R group can be reduced by Luteolin. But pre-treatment with conoidin A abolishs the effect of Luteolin. Pre-treatment with conoidin A also prevents Luteolin-reduced activities of CK-MB, AST and LDH in vivo[3].
| Animal Model: | Rat myocardial I/R model[3] |
| Dosage: | 5?mg/kg |
| Administration: | Intraperitoneal injection; 5?mg/kg; for three successive days before MI/R injury |
| Result: | Significantly reversed the antioxidative effect of Luteolin. Impaired the protective effects of luteolin. |
IC 50
Toxoplasma
2,3-BIS(BROMOMETHYL)QUINOXALINE 1,4-DIOXIDE Preparation Products And Raw materials
Raw materials
Preparation Products
2,3-BIS(BROMOMETHYL)QUINOXALINE 1,4-DIOXIDE Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32159 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30231 | 58 |
| Shenzhen Shengda Pharma Limited | 755-85269922 +8613424394241 | sales@shengdapharm.com | CHINA | 310 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| Xuzhou B&C Chemical Co.,Ltd | +86-400-0516-021 | info@bcpharma.com | China | 2738 | 58 |
| LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43340 | 58 |
| Shanghai Acmec Biochemical Technology Co., Ltd. | +86-18621343501; +undefined18621343501 | product@acmec-e.com | China | 33338 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 57505 | 58 | |
| Wuhan Jingkang en Biomedical Technology Co., Ltd | +8613720134139 | orders@jknbiochem.com | China | 5221 | 58 |
| SHANGHAI KEAN TECHNOLOGY CO., LTD. | +8613817748580 | cooperation@kean-chem.com | China | 40066 | 58 |
View Lastest Price from 2,3-BIS(BROMOMETHYL)QUINOXALINE 1,4-DIOXIDE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-11-18 | Conoidin A
18080-67-6
|
US $61.00-0.00 / mg | 98.00% | 10g | TargetMol Chemicals Inc. |
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- Conoidin A
18080-67-6
- US $61.00-0.00 / mg
- 98.00%
- TargetMol Chemicals Inc.