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CAY10638

CAY10638 Structure
CAY10638 structure
CAS No.
1221413-57-5
Chemical Name:
CAY10638
Synonyms
CAY10638;CAY10638 Exclusive;2,4-Thiazolidinedione, 5-[[4-[2-(2-thienyl)ethoxy]phenyl]methylene]-
CBNumber:
CB72590450
Molecular Formula:
C16H13NO3S2
Molecular Weight:
331.41
MDL Number:
MFCD18382124
MOL File:
1221413-57-5.mol
Last updated:2023-05-04 17:34:32
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CAY10638 Properties

solubility DMF: 30 mg/ml; DMF:PBS (pH 7.2) (1:9): 0.1 mg/ml; DMSO: 25 mg/ml
form A crystalline solid

CAY10638 price More Price(5)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 13695 CAY10638 ≥98% 1221413-57-5 1mg $32 2024-03-01 Buy
Cayman Chemical 13695 CAY10638 ≥98% 1221413-57-5 5mg $109 2024-03-01 Buy
Cayman Chemical 13695 CAY10638 ≥98% 1221413-57-5 10mg $199 2024-03-01 Buy
Cayman Chemical 13695 CAY10638 ≥98% 1221413-57-5 25mg $456 2024-03-01 Buy
AK Scientific 3625DG (5Z)-5-[[4-(2-Thiophen-2-ylethoxy)phenyl]methylidene]-1,3-thiazolidine-2,4-dione 1221413-57-5 10mg $320 2021-12-16 Buy
Product number Packaging Price Buy
13695 1mg $32 Buy
13695 5mg $109 Buy
13695 10mg $199 Buy
13695 25mg $456 Buy
3625DG 10mg $320 Buy

CAY10638 Chemical Properties,Uses,Production

Description

Prostaglandins have a short life in vivo because NAD+-dependent 15-hydroxy prostaglandin dehydrogenase (15-PGDH) catalyzes their oxidation to 15-keto metabolites with greatly reduced biological activity.1 Thiazolidinediones (TZDs) are a class of PPARγ agonists that have potent 15-PGDH inhibitory activity.2,3 CAY10638 is a TZD derivative that inhibits 15-PGDH activity with an IC50 value of 31 nM.3

Definition

ChEBI: CAY10638 is an aromatic ether.

References

1. Hansen, H.S. 15-Hydroxyprostaglandin dehydrogenase. A review Prostaglandins 12(4),647-679(1976).
2. Owens, D.R. Thiazolidinediones. An pharmacological overview Clin. Drug Investig. 22(8),485-505(2002).
3. Wu, Y., Tai, H.H., and Cho, H. Synthesis and SAR of thiazolidinedione derivatives as 15-PGDH inhibitors Bioorg. Med. Chem. 18,1428-1433(2010).

CAY10638 Preparation Products And Raw materials

Raw materials

Preparation Products

CAY10638 Suppliers

Global( 18)Suppliers
Supplier Tel Email Country ProdList Advantage
BOC Sciences 16314854226 info@bocsci.com United States 9926 65
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767 sales@chemegen.com China 11289 58
Shanghai Yifei Biotechnology Co. , Ltd. 021-65675885 18964387627 customer_service@efebio.com China 8739 58
Supplier Advantage
BOC Sciences 65
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 58
Shanghai Yifei Biotechnology Co. , Ltd. 58
CAY10638 CAY10638 Exclusive 2,4-Thiazolidinedione, 5-[[4-[2-(2-thienyl)ethoxy]phenyl]methylene]- 1221413-57-5