LY2140023 hydrochloride
- CAS No.
- 635318-26-2
- Chemical Name:
- LY2140023 hydrochloride
- Synonyms
- LY2140023 hydrochloride;Pomaglumetad methionil (hydrochloride)
- CBNumber:
- CB72658190
- Molecular Formula:
- C12H19ClN2O7S2
- Molecular Weight:
- 402.87146
- MDL Number:
- MFCD32878226
- MOL File:
- 635318-26-2.mol
LY2140023 hydrochloride price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-0024762 | Pomaglumetadmethionil(hydrochloride) 98.20% | 635318-26-2 | 5mg | $650 | 2021-12-16 | Buy |
| ChemScene | CS-0024762 | Pomaglumetadmethionil(hydrochloride) 98.20% | 635318-26-2 | 10mg | $1150 | 2021-12-16 | Buy |
| ChemScene | CS-0024762 | Pomaglumetadmethionil(hydrochloride) 98.20% | 635318-26-2 | 25mg | $2450 | 2021-12-16 | Buy |
| ChemScene | CS-0024762 | Pomaglumetadmethionil(hydrochloride) 98.20% | 635318-26-2 | 50mg | $3850 | 2021-12-16 | Buy |
| ChemScene | CS-0024762 | Pomaglumetadmethionil(hydrochloride) 98.20% | 635318-26-2 | 100mg | $5850 | 2021-12-16 | Buy |
LY2140023 hydrochloride Chemical Properties,Uses,Production
Biological Activity
Pomaglumetad methionil hydrochloride (LY2140023 hydrochloride) is an orally active, methionine prodrug of the selective mGlu2/3 receptor agonist LY404039. Pomaglumetad methionil hydrochloride has the potential for schizophrenia research[1][2]. Pomaglumetad methionil (LY2140023) is a high-affinity peptide transporter 1 (PEPT1) substrate with a Km value of ~30 μM[2].LY2140023 is active against [14C]Gly-Sar with an IC50 value of 0.018 mM[2]. Pomaglumetad methionil (LY2140023; orally; 3-300 mg/kg; once daily for 7 days) dose-dependent increases the levels of the dopamine metabolites dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) [1].
References
[1]. Lowe S, et al. Effects of a novel mGlu?/? receptor agonist prodrug, LY2140023 monohydrate, on central monoamine turnover as determined in human and rat cerebrospinal fluid. Psychopharmacology (Berl). 2012 Feb;219(4):959-70. [2]. Y Anne Pak, et al. In Vitro and Clinical Evaluations of the Drug-Drug Interaction Potential of a Metabotropic Glutamate 2/3 Receptor Agonist Prodrug with Intestinal Peptide Transporter 1. Drug Metab Dispos. 2017 Feb;45(2):137-144.
LY2140023 hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
LY2140023 hydrochloride Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd | +86-18341751992 +86-15382112998 | 757984502@qq.com | China | 892 | 58 |
| NCE Biomedical Co.,Ltd. | 4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988 | China | 1494 | 55 | |
| LETOPHARM LIMITED | +86-21-5821 5861 | sales@letopharm.com | China | 2384 | 58 |
| SPIRO PHARMA | eric_feng1954@126.com | China | 9254 | 55 | |
| ShangHai ChuanQian Chemcial Technique Centre | 15869524721 | 3525679403@qq.com | China | 3715 | 58 |
| Kaifeng Mingren Pharmaceutical Co.,LTD | 0371-65741762 | sales@hasunny.com | China | 2380 | 58 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 23963 | 58 |
| Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd | 024-024-88590548 18341751992 | 757984502@qq.com | China | 891 | 58 |