Maritoclax
- CAS No.
- 1010732-14-5
- Chemical Name:
- Maritoclax
- Synonyms
- Maritoclax;Marinopyrrole A;Methanone, 1,1'-[(1R)-4,4',5,5'-tetrachloro[1,3'-bi-1H-pyrrole]-2,2'-diyl]bis[1-(2-hydroxyphenyl)-
- CBNumber:
- CB72667196
- Molecular Formula:
- C22H12Cl4N2O4
- Molecular Weight:
- 510.15
- MDL Number:
- MOL File:
- 1010732-14-5.mol
Maritoclax Chemical Properties,Uses,Production
Description
Maritoclax, also known as Marinopyrrole A , is a small molecule Mcl-1 inhibitor, which induces Mcl-1 proteasomal degradation without transcriptional downregulation. Maritoclax killed AML cell lines and primary cells with elevated Mcl-1 levels through selective Mcl-1 downregulation, and synergized with ABT-737 to overcome Mcl-1-mediated ABT-737 resistance. Maritoclax was more effective than daunorubicin at inducing leukemic cell death when co-cultured with HS-5 bone marrow stroma cells, while being less toxic than daunorubicin against HS-5 stroma cells, primary mouse bone marrow cells, and hematopoietic progenitor cells. Moreover, maritoclax administration at 20 mg/kg/d intraperitoneally caused significant U937 tumor shrinkage, as well as 36% tumors remission rate in athymic nude mice, without apparent toxicity to healthy tissue or circulating blood cells. In summary, our studies suggest that maritoclax belongs to a novel class of Mcl-1 inhibitors that has the potential to be developed for the treatment of AML. ( Cancer Biol Ther. 2014 Aug;15(8):1077-86. )
Definition
ChEBI: (-)-marinopyrrole A is a member of the class of pyrroles that is 1'H-1,3'-bipyrrole substituted by four chloro groups at positions 4, 4', 5 and 5' and two 2-hydroxybenzoyl moieties at positions 2 and 2'. It is isolated from Streptomyces sp.CNQ-418 and exhibits cytotoxic and antibacterial activities. It has a role as an antimicrobial agent, an antibacterial agent, an antineoplastic agent, a marine metabolite and a bacterial metabolite. It is a member of pyrroles, an organochlorine compound, a member of phenols and an aromatic ketone.
Maritoclax Preparation Products And Raw materials
Raw materials
Preparation Products
Maritoclax Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Zeye Biotechnology Co., Ltd. | 021-61998551 13122364865 | sale1@shzysw.net | China | 9771 | 58 |
| Supplier | Advantage |
|---|---|
| Shanghai Zeye Biotechnology Co., Ltd. | 58 |