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CEP-18770

CEP-18770 structure

CAS No.: 847499-27-8

Chemical Name:: CEP-18770

Synonyms: CS-252;CT 47098;CEP-18770;CIP 18770;NPH 007098;Delanzomib;Delanzomib, >=98%;CEP-18770 (DelanzoMib);DelanzoMib (CEP-18770);DelanzoMib, Free Base, >99%

CBNumber:: CB42570998

Molecular Formula:: C21H28BN3O5

Molecular Weight:: 413.28

MDL Number:: MFCD18251439

MOL File:: 847499-27-8.mol

Last updated:2024-11-17 16:00:36

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CEP-18770 Properties

Melting point	178-190°C (dec.)
Density	1.207
storage temp.	Hygroscopic, -20°C Freezer, Under Inert Atmosphere
solubility	Acetonitrile (Slightly), Chloroform (Slightly), Methanol (Slightly)
form	Solid
pka	9.67±0.43(Predicted)
color	White to Off-White
Stability	Hygroscopic
FDA UNII	6IF28942WO
NCI Drug Dictionary	delanzomib

SAFETY

Risk and Safety Statements

HS Code	29333990

CEP-18770 price More Price(24)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Cayman Chemical	23557	Delanzomib ≥95%	847499-27-8	1mg	$32	2024-03-01	Buy
Cayman Chemical	23557	Delanzomib ≥95%	847499-27-8	5mg	$122	2024-03-01	Buy
Cayman Chemical	23557	Delanzomib ≥95%	847499-27-8	10mg	$214	2024-03-01	Buy
Cayman Chemical	23557	Delanzomib ≥95%	847499-27-8	50mg	$911	2024-03-01	Buy
Usbiological	007917	Delanzomib	847499-27-8	5mg	$602	2021-12-16	Buy

Product number	Packaging	Price	Buy
23557	1mg	$32	Buy
23557	5mg	$122	Buy
23557	10mg	$214	Buy
23557	50mg	$911	Buy
007917	5mg	$602	Buy

CEP-18770 Chemical Properties,Uses,Production

Description

Delanzomib is an orally bioavailable inhibitor of chymotrypsin-like proteasome activity (IC₅₀ = 3.8 nM in isolated human erythrocytes) that only marginally inhibits tryptic and peptidyl glutamyl proteasome activity. Delanzomib pre-treatment (20 nM) in vitro inhibits IκBα degradation, NF-κB activation, and the expression of NF-κB-regulated genes, including IκBα, XIAP, TNF-α, IL-1β, ICAM-1, and VEGF. Delanzomib induces apoptosis in multiple myeloma cell lines and inhibits proliferation in a panel of human hematologic and solid tumor cell lines (IC₅₀s = 5.6-34.2 nM). It reduces tumor weight in an RPMI 8226 human multiple myeloma mouse xenograft model when administered intravenously at doses ranging from 1.5-4 mg/kg twice daily and leads to complete tumor regression at a chronic oral dose of 13 mg/kg. Delanzomib reduces the serum level of circulating cytokines, prevents renal tissue damage, and increases lifespan in a mouse model of fatal lupus nephritis.

Uses

Delanzomib is an orally active proteasome inhibitor. Delanzomib has been shown to down-modulate NF-κB, induce apoptosis, inhibit angiogenesis and M-CSF-RANKL-induced osteoclastogenesis.

Definition

ChEBI: Delanzomib is a C-terminal boronic acid peptide inhibitor which induces apoptosis in multiple myeloma, hematological and solid tumor cell lines. It has a role as a proteasome inhibitor, an apoptosis inducer and an antineoplastic agent. It is a threonine derivative, a phenylpyridine, a C-terminal boronic acid peptide and a secondary alcohol. It is functionally related to a L-threonine.

target

proteasome

CEP-18770 Preparation Products And Raw materials

Raw materials

Preparation Products

CEP-18770 Suppliers

Global( 121)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Alpha Biopharmaceuticals Co., Ltd	+86-15542445688	sales@alabiochem.com	China	888	58
Hangzhou FandaChem Co.,Ltd.	+8615858145714	FandaChem@Gmail.com	China	9215	55
Hubei xin bonus chemical co. LTD	86-13657291602	linda@hubeijusheng.com	CHINA	22963	58
career henan chemical co	+86-0371-86658258 +8613203830695	factory@coreychem.com	China	29811	58
SIMAGCHEM CORP	+86-13806087780	sale@simagchem.com	China	17365	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	32112	58
Win-Win chemical CO., Limited	+86-0086-577-64498589 +86-15355981851	sales@win-winchemical.com	China	14393	58
AFINE CHEMICALS LIMITED	+86-0571-85134551	sales@afinechem.com	China	15354	58
Baoji Guokang Bio-Technology Co., Ltd.	0917-3909592 13892490616	gksales1@gk-bio.com	China	9315	58
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471	sales@sarms4muscle.com	China	10473	58

Supplier	Advantage
Alpha Biopharmaceuticals Co., Ltd	58
Hangzhou FandaChem Co.,Ltd.	55
Hubei xin bonus chemical co. LTD	58
career henan chemical co	58
SIMAGCHEM CORP	58
TargetMol Chemicals Inc.	58
Win-Win chemical CO., Limited	58
AFINE CHEMICALS LIMITED	58
Baoji Guokang Bio-Technology Co., Ltd.	58
Zhejiang J&C Biological Technology Co.,Limited	58

View Lastest Price from CEP-18770 manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-11-17	Delanzomib 847499-27-8	US $88.00-289.00 / mg		99.46%	10g	TargetMol Chemicals Inc.
2021-07-13	Delanzomib 847499-27-8	US $15.00-10.00 / KG	1KG	99%+ HPLC	Monthly supply of 1 ton	Zhuozhou Wenxi import and Export Co., Ltd
2021-07-10	Delanzomib 847499-27-8	US $15.00-10.00 / KG	1KG	99%+ HPLC	Monthly supply of 1 ton	Zhuozhou Wenxi import and Export Co., Ltd

Delanzomib
847499-27-8
US $88.00-289.00 / mg
99.46%
TargetMol Chemicals Inc.

Delanzomib
847499-27-8
US $15.00-10.00 / KG
99%+ HPLC
Zhuozhou Wenxi import and Export Co., Ltd

Delanzomib
847499-27-8
US $15.00-10.00 / KG
99%+ HPLC
Zhuozhou Wenxi import and Export Co., Ltd

CEP-18770 Spectrum

CEP-18770(847499-27-8)¹HNMR

847499-27-8(CEP-18770)Related Search:

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1of4

CEP-18770 [(1R)-1-[[(2S,3R)-3-Hydroxy-2-[[(6-phenylpyridin-2-yl)carbonyl]amino]-1-oxobutyl]amino]-3-methylbutyl]boronic acid CIP 18770 CT 47098 Delanzomib NPH 007098 CEP-18770 (DelanzoMib) DelanzoMib, Free Base, >99% ((R)-1-((2S,3R)-3-Hydroxy-2-(6-phenylpicolinaMido)butanaMido)-3-Methylbutyl)boronic acid (R)-1-((2S,3R)-3-hydroxy-2-(2-phenylpicolinamido)butanamido)-3-methylbutan-2-ylboronic acid Delanzomib [(1R)-1-[[(2S,3R)-3-Hydroxy-2-[[(6-phenylpyridin-2-yl)carbonyl]amino]-1-oxobutyl]amino]-3-methylbutyl]boronic acid Delanzomib, >=98% DelanzoMib (CEP-18770) Boronic acid, B-[(1R)-1-[[(2S,3R)-3-hydroxy-1-oxo-2-[[(6-phenyl-2-pyridinyl)carbonyl]aMino]butyl]aMino]-3-Methylbutyl]- (1R)-1-[(2S,3R)-3-hydroxy-2-[(6-phenylpyridin-2-yl)formamido]butanamido]-3-methylbutyl]boronic acid CS-252 CEP-18770;CEP 18770;CEP18770 ((R)-1-((2S,3R)-3-hydroxy-2-(6-phenylpicolinamido)butanamido)-3-methylbutan-2-yl)boronic acid 847499-27-8 C21H28BN3O5 Inhibitor Inhibitors