(S)-(-)-WARFARIN
- CAS No.
- 5543-57-7
- Chemical Name:
- (S)-(-)-WARFARIN
- Synonyms
- Warfarin,R-;(S)-WARFARIN;(S)-(-)-WARFARIN;Warfarin S-Isomer;Warfarin Impurity 17;Warfarin Impurity 17(Warfarin S-Isomer);s-(-)-3-acetonybenzyl)-4-hydroxycoumarin;S-(-)-3-(ACETONYLBENZYL)-4-HYDROXYCOUMARIN;Warfarin sodium Impurity 23 ((S)-Warfarin);2-hydroxy-3-(3-keto-1-phenyl-butyl)chromone
- CBNumber:
- CB7267099
- Molecular Formula:
- C19H16O4
- Molecular Weight:
- 308.33
- MDL Number:
- MFCD00272381
- MOL File:
- 5543-57-7.mol
- MSDS File:
- SDS
Melting point | ≥170 °C |
---|---|
storage temp. | 2-8°C |
solubility | DMF: 25 mg/ml; DMSO: 25 mg/ml; Ethanol: 5 mg/ml |
form | A crystalline solid |
color | white to pale yellow |
CAS DataBase Reference | 5543-57-7(CAS DataBase Reference) |
FDA UNII | HP31W7FNP4 |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS06,GHS08,GHS09 |
|||||||||
---|---|---|---|---|---|---|---|---|---|---|
Signal word | Danger | |||||||||
Hazard statements | H300+H310+H330-H360D-H372-H411 | |||||||||
Precautionary statements | P202-P264-P273-P280-P302+P352+P310-P304+P340+P310 | |||||||||
Hazard Codes | T | |||||||||
Risk Statements | 61-48/25-52/53 | |||||||||
Safety Statements | 53-45-61 | |||||||||
RIDADR | UN 2811 6.1/PG 1 | |||||||||
WGK Germany | 3 | |||||||||
NFPA 704 |
|
(S)-(-)-WARFARIN price More Price(11)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | UC214 | (S)-(?)-Warfarin ≥97% (HPLC) | 5543-57-7 | 5mg | $918 | 2024-03-01 | Buy |
Sigma-Aldrich | UC214 | (S)-(?)-Warfarin ≥97% (HPLC) | 5543-57-7 | 10mg | $1660 | 2024-03-01 | Buy |
Cayman Chemical | 13531 | (-)-Warfarin ≥98% | 5543-57-7 | 1mg | $74 | 2024-03-01 | Buy |
Cayman Chemical | 13531 | (-)-Warfarin ≥98% | 5543-57-7 | 5mg | $241 | 2024-03-01 | Buy |
Cayman Chemical | 13531 | (-)-Warfarin ≥98% | 5543-57-7 | 10mg | $444 | 2024-03-01 | Buy |
(S)-(-)-WARFARIN Chemical Properties,Uses,Production
Description
(–)-Warfarin is a component of (±)-warfarin . It is an anticoagulant that interferes with interconversion of vitamin K and vitamin K epoxide and the role of vitamin K in carboxylation of several clotting cascade proteins, inhibiting the initiation of clotting. In vivo, (–)-warfarin slows formation of the prothrombin complex and exhibits 6.6-fold more potent anticoagulant activity than (+)-warfarin in rats. (–)-Warfarin is primarily metabolized by the cytochrome P450 (CYP) isoform CYP2C9 and genetic polymorphisms in this enyzme, as well as other compounds metabolized by CYP2C9, increase the potential for catastrophic bleeding complications. Formulations containing warfarin have been used to treat and prevent blood clots in atrial fibrillation, heart valve replacement, venous thrombosis, and pulmonary embolism.
Chemical Properties
White Solid
Uses
The S-(-)-form of Warfarin (W498500). Coumarin anticoagulant.
Uses
(S)-(?)-Warfarin has been used in cell cultures.
Definition
ChEBI: (S)-warfarin is a 4-hydroxy-3-(3-oxo-1-phenylbutyl)-2H-1-benzopyran-2-one that has (S)-configuration (the racemate is warfarin, an anticoagulant drug and rodenticide). It is a conjugate acid of a (S)-warfarin(1-). It is an enantiomer of a (R)-warfarin.
General Description
Warfarin is an antagonist of vitamin K. It is an oral coumarin anticoagulant.
Biochem/physiol Actions
Warfarin is used to regulate and inhibit thromboembolic disorders. The CYP2C9 (cytochrome P450 family 2 subfamily C member 9)?protein plays a major role in the inactivation of potent S-warfarin.
(S)-(-)-WARFARIN Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49391 | 58 |
Shaanxi Dideu Medichem Co. Ltd | +86-29-87569266 15319487004 | 1015@dideu.com | China | 4088 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30253 | 58 |
Hebei Fengjia New Material Co., Ltd | +86-0311-87836622 +86-17333973358 | sales06@hbduling.cn | China | 15437 | 58 |
China National Standard Pharmaceutical Corporation Limited | +8615391658522 | overseasales@yongstandards.com | China | 11927 | 58 |
LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43348 | 58 |
Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131980 | 58 |
Mainchem Co., Ltd. | +86-0592-6210733 | sale@mainchem.com | China | 32360 | 55 |
View Lastest Price from (S)-(-)-WARFARIN manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2021-01-06 | (S)-(-)-WARFARIN
5543-57-7
|
US $0.37 / KG | 1KG | 99% | 10kg/100kg | Career Henan Chemica Co |
- (S)-(-)-WARFARIN
5543-57-7
- US $0.37 / KG
- 99%
- Career Henan Chemica Co
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