LY 303511 (hydrochloride)
- CAS No.
- 2070014-90-1
- Chemical Name:
- LY 303511 (hydrochloride)
- Synonyms
- CS-1207;LY 303511 (hydrochloride);LY 303511 hydrochloride, 10 mM in DMSO;8-Phenyl-2-(piperazin-1-yl)-4H-chromen-4-one hydrochloride;TNFR,LY-303511,TNF Receptor,inhibit,LY 303511,LY 303511 hydrochloride,Tumor Necrosis Factor Receptor,Inhibitor,Potassium Channel,LY303511,KcsA
- CBNumber:
- CB72715646
- Molecular Formula:
- C19H19ClN2O2
- Molecular Weight:
- 342.82
- MDL Number:
- MFCD28167798
- MOL File:
- 2070014-90-1.mol
LY 303511 (hydrochloride) price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-3206 | LY303511hydrochloride 98.78% | 2070014-90-1 | 10mg | $180 | 2021-12-16 | Buy |
| AK Scientific | 1529DY | LY303511hydrochloride | 2070014-90-1 | 50mg | $201 | 2021-12-16 | Buy |
| ChemScene | CS-3206 | LY303511hydrochloride 98.78% | 2070014-90-1 | 5mg | $120 | 2021-12-16 | Buy |
| ChemScene | CS-3206 | LY303511hydrochloride 98.78% | 2070014-90-1 | 50mg | $804 | 2021-12-16 | Buy |
| Ambeed | A182423 | LY303511Hydrochloride 98+% | 2070014-90-1 | 1g | $7055 | 2021-12-16 | Buy |
LY 303511 (hydrochloride) Chemical Properties,Uses,Production
Uses
LY 303511 hydrochloride is a structural analogue of LY294002. LY303511 does not inhibit PI3K. LY303511 enhances TRAIL sensitivity of SHEP-1 neuroblastoma cells. LY303511 reversibly blocks K+ currents (IC50=64.6±9.1 μM) in MIN6 insulinoma cells.
in vivo
Intraperitoneal administration of vehicle or LY303511 (10 mg/kg/day) is performed when tumors reach a volume of ~150 mm3, at which time 35 mice have developed a tumor. After 21 days, >15% of the mice require euthanasia because of excessive tumor growth, and these data are censored due to unreliable estimates of average tumor volume. The administration of LY303511, 10 mg/kg/day, is sufficient to inhibit PC-3 tumor growth in vivo[4].
References
[1] Bodenstine TM, et al. Homotypic gap junctional communication associated with metastasis suppression increases with PKA activity and is unaffected by PI3K inhibition. Cancer Res. 2010 Dec 1;70(23):10002-11. DOI:10.1158/0008-5472.CAN-10-2606
[2] El-Kholy W, Macdonald PE, Lin JH, The phosphatidylinositol 3-kinase inhibitor LY294002 potently blocks K(V) currents via a direct mechanism. FASEB J. 2003 Apr;17(6):720-2. DOI:10.1096/fj.02-0802fje
[3] Shenoy K, et al. LY303511 enhances TRAIL sensitivity of SHEP-1 neuroblastoma cells via hydrogen peroxide-mediated mitogen-activated protein kinase activation and up-regulation of death receptors. Cancer Res. 2009 Mar 1;69(5):1941-50. DOI:10.1158/0008-5472.CAN-08-1996
[4] Kristof AS, et al. LY303511 (2-piperazinyl-8-phenyl-4H-1-benzopyran-4-one) acts via phosphatidylinositol 3-kinase-independent pathways to inhibit cell proliferation via mammalian target of rapamycin (mTOR)- and non-mTOR-dependent mechanisms. J Pharmacol E DOI:10.1124/jpet.105.083550
LY 303511 (hydrochloride) Preparation Products And Raw materials
Raw materials
Preparation Products
LY 303511 (hydrochloride) Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32159 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49734 | 58 |
| TargetMol Chemicals Inc. | support@targetmol.com | United States | 38630 | 58 | |
| Aladdin Scientific | tp@aladdinsci.com | United States | 52924 | 58 | |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131957 | 58 |
| Haoyuan Chemexpress Co., Ltd. | 021-58950125 | info@chemexpress.com | China | 7552 | 61 |
| Sichuan Wei Keqi Biological Technology Co., Ltd. | 028-81700200 18116577057 | 3003855609@qq.com | China | 7787 | 56 |
| SPIRO PHARMA | eric_feng1954@126.com | China | 9248 | 55 | |
| Guangzhou QiYun Biotechnology Co., Ltd. | 020-61288194 61288195 | 505721671@qq.com | China | 3866 | 58 |
View Lastest Price from LY 303511 (hydrochloride) manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-11-17 | LY 303511 hydrochloride
2070014-90-1
|
US $33.00-128.00 / mg | 97.44% | 10g | TargetMol Chemicals Inc. |
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- LY 303511 hydrochloride
2070014-90-1
- US $33.00-128.00 / mg
- 97.44%
- TargetMol Chemicals Inc.