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ZK-Thiazolidinone
- CAS No.
- 891849-87-9
- Chemical Name:
- ZK-Thiazolidinone
- Synonyms
- ZK-Thiazolidinone;Acetamide, 2-cyano-2-[3-ethyl-4-oxo-5-[[[3-[2-(1-pyrrolidinyl)ethyl]phenyl]amino]methylene]-2-thiazolidinylidene]-N-(2,2,2-trifluoroethyl)-
- CBNumber:
- CB72731174
- Molecular Formula:
- C23H26F3N5O2S
- Molecular Weight:
- 493.55
- MDL Number:
- MOL File:
- 891849-87-9.mol
Last updated:2023-03-31 09:12:58
ZK-Thiazolidinone Chemical Properties,Uses,Production
Description
ZK-Thiazolidinone, also known as TAL, is an ATP-competitive inhibitor of PLK1. In vitro, ZK-Thiazolidinone counteracts the role of Plk1 in previously established functions, notably, sister chromatid separation, centrosome maturation, and bipolar spindle assembly. In vivo, ZK-Thiazolidinone selectively inhibits PLK1 and causes a prometaphase-like mitotic (G2–M) arrest. ZK-Thiazolidinone inhibits human PLK1 (IC50, 19± 12 nM) and various human and mouse tumor cell lines (IC50, 0.2–1.3 μM). ZK-Thiazolidinone impairs centrosome maturation.
ZK-Thiazolidinone Preparation Products And Raw materials
Raw materials
Preparation Products
ZK-Thiazolidinone Suppliers
Global( 1)Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 28091 | 58 |
Supplier | Advantage |
---|---|
TargetMol Chemicals Inc. | 58 |
ZK-Thiazolidinone
Acetamide, 2-cyano-2-[3-ethyl-4-oxo-5-[[[3-[2-(1-pyrrolidinyl)ethyl]phenyl]amino]methylene]-2-thiazolidinylidene]-N-(2,2,2-trifluoroethyl)-
891849-87-9