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ZK-Thiazolidinone

ZK-Thiazolidinone structure

CAS No.: 891849-87-9

Chemical Name:: ZK-Thiazolidinone

Synonyms: ZK-Thiazolidinone;Acetamide, 2-cyano-2-[3-ethyl-4-oxo-5-[[[3-[2-(1-pyrrolidinyl)ethyl]phenyl]amino]methylene]-2-thiazolidinylidene]-N-(2,2,2-trifluoroethyl)-

CBNumber:: CB72731174

Molecular Formula:: C23H26F3N5O2S

Molecular Weight:: 493.55

MDL Number:

MOL File:: 891849-87-9.mol

Last updated:2023-03-31 09:12:58

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ZK-Thiazolidinone Properties

Boiling point	604.8±55.0 °C(Predicted)
Density	1.382±0.06 g/cm3(Predicted)
pka	10.77±0.46(Predicted)

ZK-Thiazolidinone Chemical Properties,Uses,Production

Description

ZK-Thiazolidinone, also known as TAL, is an ATP-competitive inhibitor of PLK1. In vitro, ZK-Thiazolidinone counteracts the role of Plk1 in previously established functions, notably, sister chromatid separation, centrosome maturation, and bipolar spindle assembly. In vivo, ZK-Thiazolidinone selectively inhibits PLK1 and causes a prometaphase-like mitotic (G2–M) arrest. ZK-Thiazolidinone inhibits human PLK1 (IC50, 19± 12 nM) and various human and mouse tumor cell lines (IC50, 0.2–1.3 μM). ZK-Thiazolidinone impairs centrosome maturation.

ZK-Thiazolidinone Preparation Products And Raw materials

Raw materials

Preparation Products

ZK-Thiazolidinone Suppliers

Global( 1)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
TargetMol Chemicals Inc.	15002134094	marketing@targetmol.cn	China	28091	58

Supplier	Advantage
TargetMol Chemicals Inc.	58

ZK-Thiazolidinone Acetamide, 2-cyano-2-[3-ethyl-4-oxo-5-[[[3-[2-(1-pyrrolidinyl)ethyl]phenyl]amino]methylene]-2-thiazolidinylidene]-N-(2,2,2-trifluoroethyl)- 891849-87-9