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Pazopanib-d6

Pazopanib-d6 Structure
Pazopanib-d6 structure
CAS No.
1219592-01-4
Chemical Name:
Pazopanib-d6
Synonyms
Pazopanib-d6;2H6]-Pazopanib;2-methyl-5-[[4-[methyl-d3-[3-methyl-2-(methyl-d3)-2H-indazol-6-yl]amino]-2-pyrimidinyl]amino]-benzenesulfonamide;2-methyl-5-({4-[(2H?)methyl[2-(2H?)methyl-3-methyl-2H-indazol-6-yl]amino]pyrimidin-2-yl}amino)benzene-1-sulfonamide
CBNumber:
CB72741889
Molecular Formula:
C21H23N7O2S
Molecular Weight:
437.52
MDL Number:
MOL File:
1219592-01-4.mol
Last updated:2024-11-19 23:02:33
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Pazopanib-d6 Properties

storage temp. Store at -20°C
solubility DMF: 16 mg/ml; DMSO: 16 mg/ml
form A solid
color White to off-white

Pazopanib-d6 price More Price(3)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 25446 Pazopanib-d6 ≥99% deuterated forms (d1-d6) 1219592-01-4 500μg $290 2024-03-01 Buy
Cayman Chemical 25446 Pazopanib-d6 ≥99% deuterated forms (d1-d6) 1219592-01-4 1mg $549 2024-03-01 Buy
AK Scientific 3396DH 2-Methyl-5-[[4-[[3-methyl-2-(trideuteriomethyl)indazol-6-yl]-(trideuteriomethyl)amino]pyrimidin-2-yl]amino]benzenesulfonamide 1219592-01-4 1mg $710 2021-12-16 Buy
Product number Packaging Price Buy
25446 500μg $290 Buy
25446 1mg $549 Buy
3396DH 1mg $710 Buy

Pazopanib-d6 Chemical Properties,Uses,Production

Description

Pazopanib-d6 is intended for use as an internal standard for the quantification of pazopanib by GC- or LC-MS. Pazopanib is a multi-kinase inhibitor that inhibits the VEGF receptors VEGFR1, VEGFR2, and VEGFR3 (IC50s = 10, 30, and 47 nM, respectively, in a cell-free enzyme assay).1 It also inhibits PDGFRα, PDGFRβ, and c-Kit (IC50s = 71, 84, and 74 nM, respectively, in a cell-free enzyme assay) as well as additional receptor tyrosine kinases. Pazopanib inhibits upregulation of the surface adhesion proteins ICAM-1 and VCAM-1 induced by VEGF in multiple myeloma cells cocultured with human umbilical vein endothelial cells (HUVECs) and decreases multiple myeloma cell adhesion to HUVECs.2 It also inhibits proliferation of multiple myeloma cells cocultured with HUVECs. Pazopanib (30 and 100 mg/kg) reduces tumor growth, induces apoptosis, decreases angiogenesis, and increases survival in a multiple myeloma mouse xenograft model. Formulations containing pazopanib have been used in the treatment of cancer.

References

1. Kumar, R., Knick, V.B., Rudolph, S.K., et al. Pharmacokinetic-pharmacodynamic correlation from mouse to human with pazopanib, a multikinase angiogenesis inhibitor with potent antitumor and antiangiogenic activity Mol. Cancer Ther. 6(7),2012-2021(2007).
2. Podar, K., Tonon, G., Satler, M., et al. The small-molecule VEGF receptor inhibitor pazopanib (GW786034B) targets both tumor and endothelial cells in multiple myeloma Proc. Natl. Acad. Sci. USA 103(5),19478-19483(2006).

Pazopanib-d6 Preparation Products And Raw materials

Raw materials

Preparation Products

Pazopanib-d6 Suppliers

Global( 18)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		support@targetmol.com United States 38631 58
ChemStrong Scientific Co.,Ltd 0755-0755-66853366 13670046396 sales@chem-strong.com China 18070 56
Artis Biotech Co. Ltd. 0575-18780151478 18582380095 sales@artisbio.com China 2966 58
Shanghai Hongye Biotechnology Co. Ltd 400-9205774 sales@glpbio.cn China 6777 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767 sales@chemegen.com China 11218 58
Guangzhou Juntang Technology Co., Ltd 020-36607679 13502246435 sales@dmstandards.com China 10945 58
TargetMol Chemicals Inc. 4008200310 marketing@tsbiochem.com China 24644 58
Shanghai YuZn Pharm. Technology Co.,Ltd. 15921286451; 15921286451 2010681527@qq.com China 5095 58
LGC Science (Shanghai) Ltd. 17717235263 cindy.yang@lgcgroup.com China 15583 58
Shanghai Yifei Biotechnology Co. , Ltd. 021-65675885 18964387627 customer_service@efebio.com China 11974 58
Supplier Advantage
TargetMol Chemicals Inc. 		58
ChemStrong Scientific Co.,Ltd 56
Artis Biotech Co. Ltd. 58
Shanghai Hongye Biotechnology Co. Ltd 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 58
Guangzhou Juntang Technology Co., Ltd 58
TargetMol Chemicals Inc. 58
Shanghai YuZn Pharm. Technology Co.,Ltd. 58
LGC Science (Shanghai) Ltd. 58
Shanghai Yifei Biotechnology Co. , Ltd. 58

View Lastest Price from Pazopanib-d6 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Pazopanib-d6 pictures 2024-11-19 Pazopanib-d6
1219592-01-4
 US $438.00 / mg 10g TargetMol Chemicals Inc.
  • Pazopanib-d6 pictures
  • Pazopanib-d6
    1219592-01-4
  • US $438.00 / mg
  • TargetMol Chemicals Inc.

1219592-01-4(Pazopanib-d6)Related Search:

1,3-DiMethyl-6-aMino-1H-indazole 3-AMINO-4-METHYLBENZENESULFONAMIDE N-(2-Chloropyrimidin-4-YL)-2,3-dimethyl-2H-indazol-6-amine Pazopanib Impurity 9 N-(2-chloropyriMidin-4-yl)-N,2,3-triMethyl-2H-indazol-6-aMine
5-Amino-2-methylbenzenesulfonamide 2-Ethyl-5-nitrobenzenamine ,98% 3-Methyl-6-nitroindazole 2,3-dimethyl-2H-indazol-6-amine hydrochloride 4(1H)-Pyrimidinone, 2-chloro- (9CI)
1,3-Dimethyl-6-nitro-1H-indazole 3-Methyl-6-nitro-2H-indazole 2(1H)-Pyrimidinone, 4-chloro- (6CI,9CI) Pazopanib 2,3-DIMETHYL-6-NITRO-2H-INDAZOLE
Pazopanib Related Compound 2 2-Methyl-5-nitrobenzenesulfonamide 5-[[4-[(2,3-DiMethyl-2H-indazol-6-yl)aMino]-2-pyriMidinyl]aMino]-2-MethylbenzenesulfonaMide

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Pazopanib-d6 2-methyl-5-[[4-[methyl-d3-[3-methyl-2-(methyl-d3)-2H-indazol-6-yl]amino]-2-pyrimidinyl]amino]-benzenesulfonamide 2H6]-Pazopanib 2-methyl-5-({4-[(2H?)methyl[2-(2H?)methyl-3-methyl-2H-indazol-6-yl]amino]pyrimidin-2-yl}amino)benzene-1-sulfonamide 1219592-01-4