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N-(2-chloropyriMidin-4-yl)-N,2,3-triMethyl-2H-indazol-6-aMine

N-(2-chloropyriMidin-4-yl)-N,2,3-triMethyl-2H-indazol-6-aMine structure

CAS No.: 444731-75-3

Chemical Name:: N-(2-chloropyriMidin-4-yl)-N,2,3-triMethyl-2H-indazol-6-aMine

Synonyms: BNKY007-PZ02;Pazopanib Impurity 22;Pazopanib Impurity 34;Pazopanib intermediate;Pazopanib ( PAZ ) N - Methyl compound;N-(2-chloropyrimidin-4-yl)-N,2,3-trimethylindazol-6-amine;N-(2-chloro-4-pyriMidinyl)-N,2,3-triMethyl-2H-indazol-6-aMine;N-(2-chloropyriMidin-4-yl)-N,2,3-triMethyl-2H-indazol-6-aMine;N-(2-chloropyrimidin-4-yl)-N,2,3-trimethyl-1H-indazol-6-amine;2H-Indazol-6-aMine, N-(2-chloro-4-pyriMidinyl)-N,2,3-triMethyl-

CBNumber:: CB02526159

Molecular Formula:: C14H14ClN5

Molecular Weight:: 287.75

MDL Number:: MFCD12923006

MOL File:: 444731-75-3.mol

MSDS File:: SDS

Last updated:2024-06-06 16:20:44

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N-(2-chloropyriMidin-4-yl)-N,2,3-triMethyl-2H-indazol-6-aMine Properties

Melting point	167-173℃
Boiling point	524.4±35.0 °C(Predicted)
Density	1.33±0.1 g/cm3(Predicted)
storage temp.	under inert gas (nitrogen or Argon) at 2-8°C
solubility	Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Very Slightly)
pka	2.82±0.30(Predicted)
Stability	Hygroscopic
CAS DataBase Reference	444731-75-3

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P261-P280a-P304+P340-P305+P351+P338-P405-P501a

NFPA 704

	1
2		0

N-(2-chloropyriMidin-4-yl)-N,2,3-triMethyl-2H-indazol-6-aMine price More Price(17)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Alfa Aesar	H33611	6-[N-(2-chloro-4-pyrimidinyl)methylamino]-2,3-dimethyl-2H-indazole, 96%	444731-75-3	500mg	$102	2023-06-20	Buy
TRC	C380090	N-(2-Chloro-4-pyrimidinyl)-N,2,3-trimethyl-2H-indazol-6-amine	444731-75-3	1g	$155	2021-12-16	Buy
TRC	C380090	N-(2-Chloro-4-pyrimidinyl)-N,2,3-trimethyl-2H-indazol-6-amine	444731-75-3	10g	$1210	2021-12-16	Buy
Matrix Scientific	139007	N-(2-Chloropyrimidin-4-yl)-N,2,3-trimethyl-2H-indazol-6-amine 95%+	444731-75-3	1g	$1554	2021-12-16	Buy
Matrix Scientific	139007	N-(2-Chloropyrimidin-4-yl)-N,2,3-trimethyl-2H-indazol-6-amine 95%+	444731-75-3	2.500g	$3386	2021-12-16	Buy

Product number	Packaging	Price	Buy
H33611	500mg	$102	Buy
C380090	1g	$155	Buy
C380090	10g	$1210	Buy
139007	1g	$1554	Buy
139007	2.500g	$3386	Buy

N-(2-chloropyriMidin-4-yl)-N,2,3-triMethyl-2H-indazol-6-aMine Chemical Properties,Uses,Production

Chemical Properties

Light Beige to Beige Solid

Uses

N-(2-Chloro-4-pyrimidinyl)-N,2,3-trimethyl-2H-indazol-6-amine is an impurity of Pazopanib (P210925), an oral angiogenesis inhibitor targeting VEGFR and PDGFR.

Synthesis

A flask was charged with N,2,3-trimethyl-2H-indazol-6-amine (1 eq.), 2,4-dichloropyrimidine (1.5 eq.), sodium bicarbonate (2 eq.) and N, N-dimethylformamide. The reaction mixture was stirred at 85 °C until completion of the reaction. Then, water was added and stirred for 3 h. Product crystals were collected by filtration, washed with water, and then dried to get N-(2-chloropyriMidin-4-yl)-N,2,3-triMethyl-2H-indazol-6-aMine as off-white/beige powder (Yield: 97%).

N-(2-chloropyriMidin-4-yl)-N,2,3-triMethyl-2H-indazol-6-aMine synthesis

Synthesis of N-(2-chloropyriMidin-4-yl)-N,2,3-triMethyl-2H-indazol-6-aMine from 2,4-Dichloropyrimidine and 2H-Indazol-6-amine, N,2,3-trimethyl-

N-(2-chloropyriMidin-4-yl)-N,2,3-triMethyl-2H-indazol-6-aMine Preparation Products And Raw materials

Raw materials

2H-Indazol-6-amine, N,2,3-trimethyl- N-(2-Chloropyrimidin-4-YL)-2,3-dimethyl-2H-indazol-6-amine 2,4-Dichloropyrimidine Iodomethane

Preparation Products

N-(2-chloropyriMidin-4-yl)-N,2,3-triMethyl-2H-indazol-6-aMine Suppliers

Global( 195)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
BIONNA MEDICINE CO.,LTD	01056380788-8515; +8618518759099	790226113@qq.com	China	52	58
Henan Fengda Chemical Co., Ltd	+86-371-86557731 +86-13613820652	info@fdachem.com	China	20288	58
Hebei Ganmiao New material Technology Co., LTD	+86-17332992504 +86-17332992504	sales8@hbganmiao.com	China	299	58
Shanghai Daken Advanced Materials Co.,Ltd	+86-371-66670886	info@dakenam.com	China	18648	58
Beijing Cooperate Pharmaceutical Co.,Ltd	010-60279497	sales01@cooperate-pharm.com	CHINA	1803	55
Hi-Tech Chemistry Corp	0519-86626038	yuhh@hitechem.com	CHINA	810	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21639	55
Hangzhou FandaChem Co.,Ltd.	+8615858145714	FandaChem@Gmail.com	China	9220	55
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32820	60
Anqing Chico Pharmaceutical Co., Ltd.	15380796838	chloewu@chicopharm.cn	CHINA	340	58

Supplier	Advantage
BIONNA MEDICINE CO.,LTD	58
Henan Fengda Chemical Co., Ltd	58
Hebei Ganmiao New material Technology Co., LTD	58
Shanghai Daken Advanced Materials Co.,Ltd	58
Beijing Cooperate Pharmaceutical Co.,Ltd	55
Hi-Tech Chemistry Corp	58
Henan Tianfu Chemical Co.,Ltd.	55
Hangzhou FandaChem Co.,Ltd.	55
ATK CHEMICAL COMPANY LIMITED	60
Anqing Chico Pharmaceutical Co., Ltd.	58

View Lastest Price from N-(2-chloropyriMidin-4-yl)-N,2,3-triMethyl-2H-indazol-6-aMine manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-11-01	N-(2-Chloropyrimidin-4-yl)-N,2,3-trimethyl-2H-indazol-6-amine 444731-75-3	US $0.00 / kg	1kg	98%	ton	Nanjing Fred Technology Co., Ltd
2024-10-31	N-(2-chloropyriMidin-4-yl)-N,2,3-triMethyl-2H-indazol-6-aMine 444731-75-3	US $0.00 / g	10g	98%	10tons	Yangzhou Qinyuan Pharmatech Co.,ltd
2024-10-31	N-(2-chloropyriMidin-4-yl)-N,2,3-triMethyl-2H-indazol-6-aMine 444731-75-3	US $0.00 / g	10g	98%	10tons	Yangzhou Qinyuan Pharmatech Co.,ltd

N-(2-Chloropyrimidin-4-yl)-N,2,3-trimethyl-2H-indazol-6-amine
444731-75-3
US $0.00 / kg
98%
Nanjing Fred Technology Co., Ltd

N-(2-chloropyriMidin-4-yl)-N,2,3-triMethyl-2H-indazol-6-aMine
444731-75-3
US $0.00 / g
98%
Yangzhou Qinyuan Pharmatech Co.,ltd

N-(2-chloropyriMidin-4-yl)-N,2,3-triMethyl-2H-indazol-6-aMine
444731-75-3
US $0.00 / g
98%
Yangzhou Qinyuan Pharmatech Co.,ltd

444731-75-3(N-(2-chloropyriMidin-4-yl)-N,2,3-triMethyl-2H-indazol-6-aMine)Related Search:

1,3-DiMethyl-6-aMino-1H-indazole 4(1H)-Pyrimidinone, 2-chloro- (9CI) 5-[[4-[(2,3-DiMethyl-2H-indazol-6-yl)aMino]-2-pyriMidinyl]aMino]-2-MethylbenzenesulfonaMide 2(1H)-Pyrimidinone, 4-chloro- (6CI,9CI) 5-BROMO-3-METHYLINDOLE

Pazopanib Impurity 10 N-(2-Chloropyrimidin-4-YL)-2,3-dimethyl-2H-indazol-6-amine Pazopanib-d6 2,3-dimethyl-2H-indazol-6-amine hydrochloride Pazopanib Impurity 9

Pazopanib 3-Methyl-6-nitro-2H-indazole Pazopanib Related Compound 3 1,3-Dimethyl-6-nitro-1H-indazole Pazopanib Related Compound 2

(4R,12aS)-7-Methoxy-4-Methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-[1,3]oxazino[3,2-d]pyrido[1,2-a]pyrazine-9-carboxylic acid (6a,11b,16a,17a)-6,9-Difluoro-11,17-dihydroxy-16-methyl-3-oxoandrosta-1,4-diene-17-carboxylic acid 4-Acetoxy-3-acetoxymethylacetophenone

1of4

N-(2-chloropyriMidin-4-yl)-N,2,3-triMethyl-2H-indazol-6-aMine N-(2-chloro-4-pyriMidinyl)-N,2,3-triMethyl-2H-indazol-6-aMine 2H-Indazol-6-aMine, N-(2-chloro-4-pyriMidinyl)-N,2,3-triMethyl- 6-[N-(2-chloro-4-pyriMidinyl)MethylaMino]-2,3-diMethyl-2H-indazole, 96% N-(2-ChloropyriMidin-4-yl)-N-Methyl-2,3-diMethyl-2H-indazol-6-aMine 2,3-dimethyl-N-(2-chloropyrimidin-4-yl)-N-methyl-2H-indazol-6-amine BNKY007-PZ02 2H-indazole-6-aMine，N-(2-chloro -4-pyrimidinyl)-N,2,3-trimethyl- Pazopanib Impurity 22 N-(2-chloropyrimidin-4-yl)-N,2,3-trimethylindazol-6-amine N-(2- chloropyrimidine-4- group)- N- methyl-2,3-dimethyl-2 H- indazole-6-amine 6-[N-(2-chloro-4-pyrimidinyl)methylamino]-2,3-dimethyl-2H-indazole,96% N-(2-chloropyrimidine-4-yl) -N-methyl-2, 3-dimethyl-2H-indazol-6-amine Pazopanib intermediate N-(2-chloropyrimidin-4-yl)-N,2,3-trimethyl-1H-indazol-6-amine N-(2-chloropyriMidin-4-yl)-N,2,3-triMethyl-2H-indazol-6-aMine ISO 9001：2015 REACH (2-Chloro-pyrimidin-4-yl)-(2,3-dimethyl-2H-indazol-6-yl)-methyl-amine N-(2-chloropyrimidin-4-yl)-N,2,3-trimethyl-2H-indazol-6-amin... TIANFU-CHEM - N-(2-chloropyriMidin-4-yl)-N,2,3-triMethyl-2H-indazol-6-aMine Pazopanib ( PAZ ) N - Methyl compound Pazopanib Impurity 34 444731-75-3 44731-75-3