ChemicalBook >제품 카탈로그 >제약 중간체>벌크 의약품 중간체>N-(2-chloropyriMidin-4-yl)-N,2,3-triMethyl-2H-indazol-6-aMine

N-(2-chloropyriMidin-4-yl)-N,2,3-triMethyl-2H-indazol-6-aMine

N-(2-chloropyriMidin-4-yl)-N,2,3-triMethyl-2H-indazol-6-aMine 구조식 이미지

카스 번호:: 444731-75-3

상품명:: N-(2-chloropyriMidin-4-yl)-N,2,3-triMethyl-2H-indazol-6-aMine

동의어(영문):: BNKY007-PZ02;Pazopanib Impurity 22;Pazopanib Impurity 34;Pazopanil impurity 14;Pazopanib intermediate;Pazopanib ( PAZ ) N - Methyl compound;N-(2-chloropyrimidin-4-yl)-N,2,3-trimethylindazol-6-amine;N-(2-chloro-4-pyriMidinyl)-N,2,3-triMethyl-2H-indazol-6-aMine;N-(2-chloropyriMidin-4-yl)-N,2,3-triMethyl-2H-indazol-6-aMine;N-(2-chloropyrimidin-4-yl)-N,2,3-trimethyl-1H-indazol-6-amine

CBNumber:: CB02526159

분자식:: C14H14ClN5

포뮬러 무게:: 287.75

MOL 파일:: 444731-75-3.mol

속성

안전

용도

공급 업체 198

N-(2-chloropyriMidin-4-yl)-N,2,3-triMethyl-2H-indazol-6-aMine 속성

녹는점: 167-173℃

끓는 점: 524.4±35.0 °C(Predicted)

밀도: 1.33±0.1 g/cm3(Predicted)

저장 조건: under inert gas (nitrogen or Argon) at 2-8°C

용해도: 클로로포름 (약간 용해됨), 에틸아세테이트 (약간 용해됨), 메탄올(살짝살짝용해됨)

산도 계수 (pKa): 2.82±0.30(Predicted)

안정성: 흡습성

CAS 데이터베이스: 444731-75-3

안전

위험 및 안전 성명
위험 및 사전주의 사항 (GHS)

그림문자(GHS):

신호 어:

Warning

유해·위험 문구:

암호	유해·위험 문구	위험 등급	범주	신호 어	P- 코드
H315	피부에 자극을 일으킴	피부부식성 또는 자극성물질	구분 2	경고	P264, P280, P302+P352, P321,P332+P313, P362
H319	눈에 심한 자극을 일으킴	심한 눈 손상 또는 자극성 물질	구분 2A	경고	P264, P280, P305+P351+P338,P337+P313P
H335	호흡 자극성을 일으킬 수 있음	특정 표적장기 독성 - 1회 노출;호흡기계 자극	구분 3	경고

예방조치문구:

P261	분진·흄·가스·미스트·증기·...·스프레이의 흡입을 피하시오.
P304+P340	흡입하면 신선한 공기가 있는 곳으로 옮기고 호흡하기 쉬운 자세로 안정을 취하시오.
P305+P351+P338	눈에 묻으면 몇 분간 물로 조심해서 씻으시오. 가능하면 콘택트렌즈를 제거하시오. 계속 씻으시오.
P405	밀봉하여 저장하시오.

NFPA 704

	1
2		0

N-(2-chloropyriMidin-4-yl)-N,2,3-triMethyl-2H-indazol-6-aMine C화학적 특성, 용도, 생산

용도

N-(2-Chloro-4-pyrimidinyl)-N,2,3-trimethyl-2H-indazol-6-amine is an impurity of Pazopanib (P210925), an oral angiogenesis inhibitor targeting VEGFR and PDGFR.

Synthesis

A flask was charged with N,2,3-trimethyl-2H-indazol-6-amine (1 eq.), 2,4-dichloropyrimidine (1.5 eq.), sodium bicarbonate (2 eq.) and N, N-dimethylformamide. The reaction mixture was stirred at 85 °C until completion of the reaction. Then, water was added and stirred for 3 h. Product crystals were collected by filtration, washed with water, and then dried to get N-(2-chloropyriMidin-4-yl)-N,2,3-triMethyl-2H-indazol-6-aMine as off-white/beige powder (Yield: 97%).

N-(2-chloropyriMidin-4-yl)-N,2,3-triMethyl-2H-indazol-6-aMine 준비 용품 및 원자재

원자재

2H-Indazol-6-amine, N,2,3-trimethyl- N-(2-Chloropyrimidin-4-YL)-2,3-dimethyl-2H-indazol-6-amine 2,4-Dichloropyrimidine 요오드 메탄

준비 용품

N-(2-chloropyriMidin-4-yl)-N,2,3-triMethyl-2H-indazol-6-aMine 공급 업체

글로벌( 198)공급 업체

공급자	전화	이메일	국가	제품 수	이점
BIONNA MEDICINE CO.,LTD	01056380788-8515; +8618518759099	790226113@qq.com	China	52	58
Henan Fengda Chemical Co., Ltd	+86-371-86557731 +86-13613820652	info@fdachem.com	China	20283	58
Hebei Ganmiao New material Technology Co., LTD	+86-17332992504 +86-17332992504	sales8@hbganmiao.com	China	300	58
Hebei Zhuanglai Chemical Trading Co Ltd	+86-16264648883 +86-16264648883	niki@zlchemi.com	China	3001	58
Shanghai Daken Advanced Materials Co.,Ltd	+86-371-66670886	info@dakenam.com	China	18751	58
Beijing Cooperate Pharmaceutical Co.,Ltd	010-60279497	sales01@cooperate-pharm.com	CHINA	1803	55
Hi-Tech Chemistry Corp	0519-86626038	yuhh@hitechem.com	CHINA	810	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21634	55
Hangzhou FandaChem Co.,Ltd.	+8615858145714	FandaChem@Gmail.com	China	8938	55
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32956	60

N-(2-chloropyriMidin-4-yl)-N,2,3-triMethyl-2H-indazol-6-aMine 관련 검색:

1,3-DiMethyl-6-aMino-1H-indazole 4(1H)-Pyrimidinone, 2-chloro- (9CI) 5-[[4-[(2,3-DiMethyl-2H-indazol-6-yl)aMino]-2-pyriMidinyl]aMino]-2-MethylbenzenesulfonaMide 2(1H)-Pyrimidinone, 4-chloro- (6CI,9CI) 5-BROMO-3-METHYLINDOLE Pazopanib Impurity 10 N-(2-Chloropyrimidin-4-YL)-2,3-dimethyl-2H-indazol-6-amine Pazopanib-d6 2,3-dimethyl-2H-indazol-6-amine hydrochloride Pazopanib Impurity 9 Pazopanib 3-Methyl-6-nitro-2H-indazole Pazopanib Related Compound 3 1,3-Dimethyl-6-nitro-1H-indazole Pazopanib Related Compound 2 (4R,12aS)-7-Methoxy-4-Methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-[1,3]oxazino[3,2-d]pyrido[1,2-a]pyrazine-9-carboxylic acid (6a,11b,16a,17a)-6,9-Difluoro-11,17-dihydroxy-16-methyl-3-oxoandrosta-1,4-diene-17-carboxylic acid 4-Acetoxy-3-acetoxymethylacetophenone