N,N-Dicyclohexyl-5-cyclopropyl-3-isoxazolecarboxamide
- CAS No.
- 945128-26-7
- Chemical Name:
- N,N-Dicyclohexyl-5-cyclopropyl-3-isoxazolecarboxamide
- Synonyms
- ML249;CYM5541;CYM-5541;CID-17253208;CYM 5541(ML-249);CYM-5541, 10 mM in DMSO;CYM-5541;CYM 5541;ML-249;ML 249;ML249;N,N-Dicyclohexyl-5-cyclopropyl-3-isoxazolecarboxamide;N,N-Dicyclohexyl-5-cyclopropylisoxazole-3-carboxamide;3-Isoxazolecarboxamide, N,N-dicyclohexyl-5-cyclopropyl-
- CBNumber:
- CB72750683
- Molecular Formula:
- C19H28N2O2
- Molecular Weight:
- 316.44
- MDL Number:
- MFCD09782785
- MOL File:
- 945128-26-7.mol
| Boiling point | 503.1±38.0 °C(Predicted) |
|---|---|
| Density | 1.14±0.1 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | DMSO: soluble5mg/mL, clear (warmed) |
| pka | -2.57±0.20(Predicted) |
| form | powder |
| color | white to beige |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month. |
| UNSPSC Code | 12352211 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302 | |||||||||
| Precautionary statements | P280-P305+P351+P338 | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22 | |||||||||
| WGK Germany | 3 | |||||||||
| NFPA 704 |
|
N,N-Dicyclohexyl-5-cyclopropyl-3-isoxazolecarboxamide price More Price(45)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML0680 | CYM-5541 ≥98% (HPLC) | 945128-26-7 | 5mg | $123 | 2024-03-01 | Buy |
| Sigma-Aldrich | SML0680 | CYM-5541 ≥98% (HPLC) | 945128-26-7 | 25mg | $154.4 | 2024-03-01 | Buy |
| Cayman Chemical | 15190 | CYM 5541 ≥98% | 945128-26-7 | 5mg | $62 | 2024-03-01 | Buy |
| Cayman Chemical | 15190 | CYM 5541 ≥98% | 945128-26-7 | 10mg | $115 | 2024-03-01 | Buy |
| Cayman Chemical | 15190 | CYM 5541 ≥98% | 945128-26-7 | 25mg | $211 | 2024-03-01 | Buy |
N,N-Dicyclohexyl-5-cyclopropyl-3-isoxazolecarboxamide Chemical Properties,Uses,Production
Description
The sphingosine 1-
Uses
CYM 5541, is a selective allosteric agonist of SAR and S1P3 receptors.
Biochem/physiol Actions
CYM-5541 is an allosteric agonist selective for the Sphingosine 1-phosphate (S1P) S1P3 receptor subtype. CYM-5541 occupies a different chemical space in the ligand binding pocket of S1P3 than S1P does, a lower hydrophobic region around transmembrane helix TM6. CYM-5541 shows great selectivity and stability with an EC50 of between 72 and 132 nM compared to S1P1 EC50 > 10 μM, S1P2 EC50 > 50 μM, S1P4 EC50 > 50 μM, and S1P5 EC50 > 25 μM and no significant activities for a panel of 55 GPCRs, ion channels, and transporters.
storage
Store at +4°C
References
1) Guerrero?et al.?(2011),?Probe Development Efforts for an Allosteric Agonist of Sphingosine 1-phosphate Receptor 3 (S1P3); Probe Reports from the NIH Molecular Libraries Program 2) Jo?et al.?(2012),?Novel Selective Allosteric and Bitopic Ligands for the S1P3 Receptor; ACS Chem. Biol.?7?1975
N,N-Dicyclohexyl-5-cyclopropyl-3-isoxazolecarboxamide Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32159 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30231 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| TargetMol Chemicals Inc. | support@targetmol.com | United States | 38630 | 58 | |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 57505 | 58 | |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131957 | 58 |
| Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. | 025-66099280 17798518460 | cfzhang@aikonchem.com | China | 19915 | 55 |
| Guangzhou Isun Pharmaceutical Co., Ltd | 020-39119399 18927568969 | isunpharm@qq.com | China | 4720 | 55 |
