N,N-Dicyclohexyl-5-cyclopropyl-3-isoxazolecarboxamide
|
|
|
- CAS-Nr.
- 945128-26-7
- Englisch Name:
- N,N-Dicyclohexyl-5-cyclopropyl-3-isoxazolecarboxamide
- Synonyma:
- ML249;CYM5541;CYM-5541;CID-17253208;CYM 5541(ML-249);CYM-5541;CYM 5541;ML-249;ML 249;ML249;N,N-Dicyclohexyl-5-cyclopropyl-3-isoxazolecarboxamide;N,N-Dicyclohexyl-5-cyclopropylisoxazole-3-carboxamide;3-Isoxazolecarboxamide, N,N-dicyclohexyl-5-cyclopropyl-;N,N-dicyclohexyl-5-cyclopropyl-1,2-oxazole-3-carboxamide
- CBNumber:
- CB72750683
- Summenformel:
- C19H28N2O2
- Molgewicht:
- 316.44
- MOL-Datei:
- 945128-26-7.mol
|
N,N-Dicyclohexyl-5-cyclopropyl-3-isoxazolecarboxamide Eigenschaften
- Siedepunkt:
- 503.1±38.0 °C(Predicted)
- Dichte
- 1.14±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- Löslichkeit
- DMSO: soluble5mg/mL, clear (warmed)
- pka
- -2.57±0.20(Predicted)
- Aggregatzustand
- powder
- Farbe
- white to beige
- Stabilität:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
Sicherheit
- Risiko- und Sicherheitserklärung
- Gefahreninformationscode (GHS)
| Kennzeichnung gefährlicher |
Xn |
|
|
| R-Sätze: |
22 |
|
|
| WGK Germany |
3 |
|
|
| Bildanzeige (GHS) |
|
| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitsschädlich bei Verschlucken. |
Akute Toxizität oral |
Kategorie 4 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P270, P301+P312, P330, P501 |
|
| Sicherheit |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen. |
|
N,N-Dicyclohexyl-5-cyclopropyl-3-isoxazolecarboxamide Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
The sphingosine 1-
phosphate (S1P) receptor S1P
3 has roles in vasodilation, epithelial barrier function, cardioprotection, fibrosis, immunity, and inflammation. CYM 5541 is a selective, allosteric agonist of S1P
3 (EC
50 = 72-
132 nM). It less effectively activates S1P
1 (EC
50 = 28-
38 μM) and is ineffective at S1P
2, S1P
4, and S1P
5 as well as a panel of other receptors, ion channels and transporters.
Verwenden
CYM 5541, is a selective allosteric agonist of SAR and S1P3 receptors.
Biochem/physiol Actions
CYM-5541 is an allosteric agonist selective for the Sphingosine 1-phosphate (S1P) S1P3 receptor subtype. CYM-5541 occupies a different chemical space in the ligand binding pocket of S1P3 than S1P does, a lower hydrophobic region around transmembrane helix TM6. CYM-5541 shows great selectivity and stability with an EC50 of between 72 and 132 nM compared to S1P1 EC50 > 10 μM, S1P2 EC50 > 50 μM, S1P4 EC50 > 50 μM, and S1P5 EC50 > 25 μM and no significant activities for a panel of 55 GPCRs, ion channels, and transporters.
N,N-Dicyclohexyl-5-cyclopropyl-3-isoxazolecarboxamide Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
N,N-Dicyclohexyl-5-cyclopropyl-3-isoxazolecarboxamide Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 73)Lieferanten
- CYM5541
- CYM-5541
- ML249
- N,N-Dicyclohexyl(5-cyclopropylisoxazol-3-yl)-carboxamide
- N,N-Dicyclohexyl-5-cyclopropyl-3-isoxazolecarboxamide
- CYM 5541(ML-249)
- CYM-5541;CYM 5541;ML-249;ML 249;ML249
- N,N-dicyclohexyl-5-cyclopropyl-1,2-oxazole-3-carboxamide
- CID-17253208
- 3-Isoxazolecarboxamide, N,N-dicyclohexyl-5-cyclopropyl-
- CYM5541,inhibit,ML-249,LPL Receptor,CYM-5541,ML 249,Inhibitor,Lysophospholipid Receptor
- N,N-Dicyclohexyl-5-cyclopropylisoxazole-3-carboxamide
- 945128-26-7
