1,2-Dichloroethane
- CAS No.
- 107-06-2
- Chemical Name:
- 1,2-Dichloroethane
- Synonyms
- DCE;EDC;1,2-DCE;ETHYLENE DICHLORIDE;ETHYLENE CHLORIDE;CH2ClCH2Cl;1,2-Dichlorethane;1,2-Dichlorethan;Ethane,1,2-dichloro-;ethylene dichloride (eDC)
- CBNumber:
- CB7295478
- Molecular Formula:
- C2H4Cl2
Lewis structure
- Molecular Weight:
- 98.96
- MDL Number:
- MFCD00000963
- MOL File:
- 107-06-2.mol
- MSDS File:
- SDS
| Melting point | -35 °C (lit.) |
|---|---|
| Boiling point | 83 °C (lit.) |
| Density | 1.256 g/mL at 25 °C (lit.) |
| vapor density | 3.4 (20 °C, vs air) |
| vapor pressure | 87 mm Hg ( 25 °C) |
| refractive index |
n |
| Flash point | 60 °F |
| storage temp. | 0-6°C |
| solubility | 7.9g/l |
| form | Liquid |
| color | APHA: ≤10 |
| Relative polarity | 0.327 |
| Odor | Chloroform-like odor |
| explosive limit | 6.2-15.9%(V) |
| Water Solubility | 8.7 g/L (20 ºC) |
| Merck | 14,3797 |
| BRN | 605264 |
| Henry's Law Constant | 11.24 at 30 °C (headspace-GC, Sanz et al., 1997) |
| Exposure limits | TLV-TWA 10 ppm (～40 mg/m3) (ACGIH), 1 ppm (NIOSH), 50 ppm (MSHA and OSHA); ceiling 2 ppm/15 min (NIOSH); carcinogenicity: Animal Sufficient Evidence, Human Limited Evidence (IARC). |
| Dielectric constant | 10.7（20℃） |
| Stability | Volatile |
| EPA Primary Drinking Water Standard | MCL:0.005,MCLG:zero |
| LogP | 1.45 at 20℃ |
| FDA 21 CFR | 173.230; 573.440; 172.710; 173.315; 175.105; 177.1580; 73.345; 73.615 |
| Substances Added to Food (formerly EAFUS) | ETHYLENE DICHLORIDE |
| CAS DataBase Reference | 107-06-2(CAS DataBase Reference) |
| EWG's Food Scores | 7-10 |
| FDA UNII | 55163IJI47 |
| Proposition 65 List | Ethylene dichloride (1,2-Dichloroethane) |
| IARC | 2B (Vol. 20, Sup 7, 71) 1999 |
| NIST Chemistry Reference | Ethane, 1,2-dichloro-(107-06-2) |
| EPA Substance Registry System | 1,2-Dichloroethane (107-06-2) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H350 | |||||||||
| Precautionary statements | P201-P202-P280-P308+P313-P405-P501 | |||||||||
| Hazard Codes | F,T | |||||||||
| Risk Statements | 45-11-22-36/37/38-23/25-23 | |||||||||
| Safety Statements | 53-45-24-16-7 | |||||||||
| OEB | B | |||||||||
| OEL | TWA: 1 ppm (4 mg/m3), STEL: 2 ppm (8 mg/m3) (Chloroethanes) | |||||||||
| RIDADR | UN 1184 3/PG 2 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | KI0525000 | |||||||||
| F | 3-10 | |||||||||
| Autoignition Temperature | 775 °F | |||||||||
| TSCA | Yes | |||||||||
| HS Code | 2903 15 00 | |||||||||
| HazardClass | 3 | |||||||||
| PackingGroup | II | |||||||||
| Hazardous Substances Data | 107-06-2(Hazardous Substances Data) | |||||||||
| Toxicity | LD50 orally in rats: 770 mg/kg (Smyth) | |||||||||
| IDLA | 50 ppm | |||||||||
| NFPA 704 |
|
1,2-Dichloroethane price More Price(57)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | PHR2108 | 1,2-Dichloroethane Pharmaceutical Secondary Standard; Certified Reference Material | 107-06-2 | 3x1.2mL | $145 | 2024-03-01 | Buy |
| Sigma-Aldrich | DX0800 | 1,2-Dichloroethane Meets ACS Specifications, Meets Reagent Specifications for testing USP/NF monographs GR ACS | 107-06-2 | 4L | $375 | 2024-03-01 | Buy |
| Sigma-Aldrich | 319929 | 1,2-Dichloroethane ACS reagent, ≥99.0% | 107-06-2 | 18L | $633 | 2024-03-01 | Buy |
| Sigma-Aldrich | 48613 | 1,2–Dichloroethane solution certified reference material, 200?μg/mL in methanol | 107-06-2 | 1mL | $31 | 2024-03-01 | Buy |
| Sigma-Aldrich | 284505 | 1,2-Dichloroethane anhydrous, 99.8% | 107-06-2 | 1l | $156 | 2024-03-01 | Buy |
1,2-Dichloroethane Chemical Properties,Uses,Production
Description
1,2-Dichloroethane, also called ethylene dichloride (EDC), is a manufactured chemical that is not found naturally in the environment. It is used principally to synthesize vinyl chloride, which is further used to produce a variety of vinyl based plastics products, such as polyvinyl chloride (PVC) pipes, furniture, automobile upholstery, wall coverings, housewares, and automobile parts. It is used in solvents in closed systems for various extraction and cleaning purposes in organic synthesis. It is used as a leaded gasoline additive to remove lead, but with declining tendency. It is used as a dispersant in rubber and plastics, as a wetting and penetrating agent. It was used in ore flotation, as a metal degreaser, and in textile and PVC cleaning. It was also used as an insect fumigant for stored grains and in mushroom houses, a soil fumigant in peach and apple orchards. But due to its toxicity, it is no longer registered for use as an insect fumigant in the United States (IARC 1999).
1,2-Dichloroethane structure
Chemical Properties
1,2-Dichloroethane is a clear and colorless, flammable liquid which has a pleasant, chloroform-like odor, and a sweetish taste. Decomposes slowly: turns dark and acidic on contact with air, moisture, and light. The Odor Threshold is 100 ppm.It is a volatile compound. It is relatively insoluble in water (8.6 × 103 mg/l at 25 °C) but soluble in various organic solvents and is miscible with alcohol, chloroform, and ether (NLM, 2013). 1,2-Dichloroethane is one of the highest volume chemicals used in the United States. It is also used as an extraction solvent, as a solvent for textile cleaning and metal degreasing, in certain adhesives, and as a component in fumigants for upholstery, carpets, and grain.
Physical properties
Clear, colorless, oily liquid with a pleasant, chloroform-like odor. The average least detectable odor threshold concentrations in water at 60 °C and in air at 40 °C were 12 and 52 mg/L, respectively (Alexander et al., 1982). Experimentally determined detection and recognition odor threshold concentrations were 25 mg/m3 (6 ppmv) and 165 mg/m3 (41 ppmv), respectively (Hellman and Small, 1974).
Uses
1,2-Dichloroethane is used in the manufacture of acetyl cellulose and vinyl chloride; inpaint removers; as a fumigant; as a degreaser;as a wetting agent; and as a solvent for oils,waxes, gums, resins, and rubber. It has been used as insect and soil fumigant.
Application
1,2-dichloroethane (Ethylene dichloride), also known as EDC, is produced by reacting chlorine or anhydrous hydrochloric acid with ethylene. The largest single use for EDC is the production of vinyl chloride monomer, which is used to produce poly vinyl chloride (PVC). It has many uses in industry, with principal ones being the following:
As an intermediate in the manufacture of methyl chloroform, perchloroethylene, ethylene amines, polyvinyl chloride (PVC), sulfide compounds, vinyl chloride, and trichloroethane.
As an additive in gasoline (used as a lead scavenger), pharmaceutical products, color film, and pesticides.
As a solvent for rubber, tobacco extract, paint, printing inks, and varnish.
Miscellaneous uses include as an ingredient in fingernail polish, for metal degreasing, in extracting spices, and as a dry cleaning agent.
Preparation
The first synthesis of 1,2-dichloroethane was achieved in 1795. 1,2-Dichloroethane is industrially produced by chlorination of ethylene. This chlorination can either be carried out by using chlorine (direct chlorination) or hydrogen chloride (oxychlorination) as a chlorinating agent. It is also produced by oxychlorination—ethylene, hydrogen chloride, and air are reacted at about 250 °C with a copper chloride catalyst. In the United States, almost all ethylene dichloride produced at present is used as the starting material for preparation of vinyl chloride monomer.
Definition
ChEBI: 1,2-dichloroethane is a member of the class of chloroethanes substituted by two chloro groups at positions 1 and 2. It has a role as a non-polar solvent, a hepatotoxic agent and a mutagen.
General Description
Ethylene Dichloride is a clear colorless liquid with a pleasant chloroform-like smell that emits toxic fumes of hydrochloric acid when heated to decomposition. Denser than water and insoluble in water. Vapors are heavier than air. Density 10.4 lb/gal. It is primarily used to produce vinyl chloride. Inhalation exposure to this substance induces respiratory distress, nausea and vomiting and affects the central nervous system, liver and kidneys. It is mutagenic in animals and is reasonably anticipated to be a human carcinogen. (NCI05)
Air & Water Reactions
Highly flammable. Slightly water soluble.
Reactivity Profile
Liquid ammonia and 1,2-Dichloroethane can cause an explosion when mixed, NFPA 491M, 1991. A tank of dimethyl amino propyl amine exploded violently when 1,2-Dichloroethane reacted with wet 1,2-Dichloroethane which had been the tank's previous contents [Doyle 1973]. Halogenated aliphatic compounds, such as 1,2-Dichloroethane , are moderately or very reactive. Reactivity generally decreases with increased degree of substitution of halogen for hydrogen atoms. Materials in this group are incompatible with strong oxidizing and reducing agents. Also, they are incompatible with many amines, nitrides, azo/diazo compounds, alkali metals, epoxides, aluminum
Hazard
Toxic by ingestion, inhalation, and skin absorption; strong irritant to eyes and skin; a carcinogen. Flammable, dangerous fire risk, explosive limits in air 6–16%. Possible carcinogen.
Health Hazard
The toxic symptoms from exposure to 1,2-dichloroethane include depression of the cen tral nervous system, irritation of the eyes,corneal opacity, nausea, vomiting, diarrhea,ulceration, somnolence, cyanosis, pulmonaryedema, and coma. Repeated exposure mayproduce injury to the kidney and liver. Inges tion of the liquid can cause death. A fataldose in humans may range between 30 and50 mL. The liquid is an irritant to the skinand damaging to the eyes.
LC50 value, inhalation (rats): 1000 ppm/7 hLD50 value, oral (rabbits): 860 mg/kg
1,2-Dichloroethane tested positive to thehistidine reversion–Ames test and othermutagenic tests. The compound is carcino genic to animals. Inhalation or oral adminis tration caused lung, gastrointestinal, and skincancers in mice and rats.
Fire Hazard
Flammable liquid; burns with a smoky flame;
flash point (closed cup) 13°C (56°F), (open
cup) 18°C (65°F); vapor pressure 62 torr at
20°C (68°F); the vapor is heavier than air and
can travel a considerable distance to a source
of ignition and flash back; autoignition tem perature 413°C (775°F); fire-extinguishing
agent: dry chemical, CO2, or foam; water
may be used to keep fire-exposed contain ers cool and to disperse the vapors and flush
away any spill.
1,2-Dichloroethane forms explosive mix tures with air, with LEL and UEL val ues of 6.2% and 16.0% by volume in air,
respectively. Its reactions with alkali met als, powdered aluminum, or magnesium can
be violent. It forms explosive mixtures with
nitrogen tetroxide.
Flammability and Explosibility
Highly flammable
Trade name
BORER SOL®; BROCIDE®; DESTRUXOL BORER-SOL®; DOWFUME®[C]; DUTCH LIQUID®; DUTCH OIL®
Safety Profile
Confirmed carcinogen with experimental carcinogenic, neoplastigenic, and tumorigenic data. An experimental transplacental carcinogen. A human poison by ingestion. Poison experimentally by intravenous and subcutaneous routes. Moderately toxic by inhalation, skin contact, and intraperitoneal routes. Human systemic effects by ingestion and inhalation: flaccid paralysis without anesthesia (usually neuromuscular blockage), somnolence, cough, jaundce, nausea or vomiting, hypermoulity, diarrhea, ulceration or bleeding from the stomach, fatty liver degeneration, change in cardiac rate, cyanosis, and coma. It may also cause dermatitis, edema of the lungs, toxic effects on the kidneys, and severe corneal effects. A strong narcotic. Experimental teratogenic and reproductive effects. A skin and severe eye irritant, and strong local irritant. Its smell and irritant effects warn of its presence at relatively safe concentrations. Human mutation data reported.
Potential Exposure
In recent years, 1,2-dichloroethane is used in the production of vinyl chloride and as a leadscavenging agent in petrol; it has found wide use in the manufacture of ethylene glycol, diaminoethylene, polyvinyl chloride; nylon, viscose rayon; styrenebutadiene rubber, and various plastics. It is a solvent for resins, asphalt, bitumen, rubber, cellulose acetate; cellulose ester; and paint; a degreaser in the engineering, textile, and petroleum industries; and an extracting agent for soybean oil and caffeine. It is also used as an antiknock agent in gasoline; a pickling agent; a fumigant; and a dry-cleaning agent. It has found use in photography, xerography, and water softening; and also in the production of adhesives, cosmetics, pharmaceuticals, and varnishes.
First aid
If this chemical gets into the eyes, remove anycontact lenses at once and irrigate immediately for at least15 min, occasionally lifting upper and lower lids. Seek medical attention immediately. If this chemical contacts theskin, remove contaminated clothing and wash immediatelywith soap and water. Seek medical attention immediately. Ifthis chemical has been inhaled, remove from exposure,begin rescue breathing (using universal precautions, including resuscitation mask) if breathing has stopped and CPR ifheart action has stopped. Transfer promptly to a medicalfacility. When this chemical has been swallowed, get medical attention. Give large quantities of water and inducevomiting. Do not make an unconscious person vomit.Medical observation is recommended for 24- 48 h afterbreathing overexposure, as pulmonary edema may bedelayed. As first aid for pulmonary edema, a doctor orauthorized paramedic may consider administering a corticosteroid spray.
Carcinogenicity
1,2-Dichloroethane is reasonably anticipated to be a human carcinogen based on sufficient evidence of carcinogenicity from studies in experimental animals.
Source
Improper use of insecticidal fumigant formulation containing 1,2-dichloropropane and carbon tetrachloride (Granosan).
Environmental Fate
Biological. Methanococcus thermolithotrophicus, Methanococcus deltae, and
Methanobacterium thermoautotrophicum metabolized 1,2-dichloroethane releasing methane and
ethylene (Belay and Daniels, 1987). 1,2-Dichloroethane showed slow to moderate biodegradative
activity with concomitant rate of volatilization in a static-culture flask-screening test (settled
domestic wastewater inoculum) conducted at 25 °C. At concentrations of 5 and 10 mg/L, percent
losses after 4 wk of incubation were 63 and 53, respectively. At a substrate concentration of 5
mg/L, 27% was lost due to volatilization after 10 d (Tabak et al., 1981).
Photolytic. Titanium dioxide suspended in an aqueous solution and irradiated with UV light (λ
= 365 nm) converted 1,2-dichloroethane to carbon dioxide at a significant rate (Matthews, 1986).
The rate constant for the reaction of 1,2-dichloroethane and OH radicals in the atmosphere at
300 K is 1.3 x 10-11 cm3/molecule?sec (Hendry and Kenley, 1979). At 296 K, a photooxidation rate
constant of 2.2 x 10-13 cm3/molecule?sec was reported for the reaction with OH radicals resulting
in a half-life of 1.7 months (Howard and Evenson, 1976).
Chemical/Physical. Anticipated products from the reaction of 1,2-dichloroethane with ozone or
OH radicals in the atmosphere are chloroacetaldehyde, chloroacetyl chloride, formaldehyde, and
ClHCHO (Cupitt, 1980).
Metabolic pathway
Resting cell suspensions of the soil methylotroph Methylosinus trichosporium OB-3b rapidly dehalogenate 1,2-dichloroethane, resulting in the formation of chloroethanol via direct hydroxylation of one of the C-Cl bonds, and this ethanol is rapidly oxidized to yield chloroacetic acid.
storage
Ethylene dichloride should be kept protected against physical damage. Store in a cool, dry, well-ventilated location, away from any area where the fi re hazard may be acute. Outside or detached storage is preferred. Separate from incompatibles. Containers should be bonded and grounded for transfer to avoid static sparks.
Shipping
UN1184 Ethylene dichloride, Hazard Class: 3; Labels: 3-Flammable liquid, 6.1-Poisonous materials. Note: United States DOT 49CFR172.101, Inhalation Hazardous Chemical as 1,2-Dichloroethane
Purification Methods
It is usually prepared by chlorinating ethylene, so that likely impurities include higher chloro derivatives and other chloro compounds depending on the impurities originally present in the ethylene. It forms azeotropes with water, MeOH, EtOH, trichloroethylene, CCl4 and isopropanol. Its azeotrope with water (containing 8.9% water, and b 77o) can be used to remove gross amounts of water prior to final drying. As a preliminary purification step, it can be steam distilled, and the lower layer is treated as below. Shake it with conc H2SO4 (to remove alcohol added as an oxidation inhibitor), wash with water, then dilute KOH or aqueous Na2CO3 and again with water. After an initial drying with CaCl2, MgSO4 or by distillation, it is refluxed with P2O5, CaSO4 or CaH2 and fractionally distilled. Carbonyl-containing impurities can be removed as described for chloroform. [Beilstein 1 IV 131.]
Degradation
Ethylene dichloride (1) had been detected in surface and ground water as
an environmental contaminant, resulting from both industrial and
agricultural uses. It is also detected following the chlorination of drinking
water. Ethylene dichloride is stable to hydrolytic degradation at
environmentally relevant pH and temperature.
The primary dissipation mechanism of ethylene dichloride is volatilisation
(DT50 30 min, Moore et al., 1991). Ethylene dichloride interacts with
hydroxyl radicals produced by photo-oxidation in air to yield chloracetyl
chloride (2, Howard and Evenson, 1976; Radding et al., 1977).
The DT50 of ethylene dichloride in the vapour phase under atmospheric
photo-oxidation conditions was 12-122 days (Atkinson, 1985).
Toxicity evaluation
The estimated daily intake of 1,2-dichloroethane was similar for each rat strain at each dose level. Rats administered drinking water containing 8,000 ppm 1,2-dichloroethane received an esti mated intake of about 500-725 mg/kg per day. This estimated daily intake is close to the report ed oral LDso for 1,2-dichloroethane adminis tered by gavage (680-850 mg/kg) (McCollister et al., 1956); however, intake of this dose over 24 hours rather than as a bolus resulted in little toxicity.
1,2-Dichloroethane toxicity administered by gavage or in formulated drinking water was compared in F344/N rats. Gavage doses were calculated to be approximately equivalent (in milligrams per kilogram) to the range of expo sures resulting from the formulated water mix tures. The F344/N rats were more sensitive to 1,2-dichloroethane administered by gavage than in drinking water, as evidenced by the fact that all males receiving 240 and 480 mg/kg and 9/10 females receiving 300 mg/kg died before the end of the studies.
Toxic encephalopathy is the most common and serious disorder resulting from DCE intoxication.
Incompatibilities
May form explosive mixture with air. Reacts violently with strong oxidizers and caustics; chemically active metals, such as magnesium or aluminum powder, sodium and potassium; alkali metals; alkali amides; liquid ammonia. Decomposes to vinyl chloride and HCl above 600℃. Attacks plastics, rubber, coatings. Attacks many metals in presence of water.
Waste Disposal
Incineration, preferably after mixing with another combustible fuel. Care must be exercised to assure complete combustion to prevent the formation of phosgene. An acid scrubber is necessary to remove the halo acids produced
Precautions
Occupational workers should avoid use of ethylene dichloride along with oxidizing agents, strong alkalis, strong caustics, magnesium, sodium, potassium, active amines, ammonia List of Chemical Substances
References
https://www.atsdr.cdc.gov/substances/toxsubstance.asp?toxid=110
[2] http://apps.who.int/iris/bitstream/10665/42027/1/9241530014.pdf
[3] https://www.epa.gov/sites/production/files/2016-09/documents/ethylene-dichloride.pdf
1,2-Dichloroethane Preparation Products And Raw materials
Raw materials
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Preparation Products
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| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| SHANGHAI KEAN TECHNOLOGY CO., LTD. | +8613817748580 | cooperation@kean-chem.com | China | 40066 | 58 |
| Hebei Weibang Biotechnology Co., Ltd | +8615531157085 | abby@weibangbio.com | China | 8810 | 58 |
| Hebei Mojin Biotechnology Co., Ltd | +86 13288715578 +8613288715578 | sales@hbmojin.com | China | 12837 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20285 | 58 |
| Qingdao RENAS Polymer Material Co., Ltd. | +86-0532-86867058 +86-18562606086 | sales@qdrenas.com | China | 476 | 58 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | info@dakenam.com | China | 18751 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21634 | 55 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28172 | 58 |
| Xiamen AmoyChem Co., Ltd | +86-86-5926051114 +8618959220845 | sales@amoychem.com | China | 6383 | 58 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22963 | 58 |
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View Lastest Price from 1,2-Dichloroethane manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-11-27 | 1,2-Dichloroethane
107-06-2
|
US $10.00 / KG | 1KG | 99% | 100 mt | Hebei Weibang Biotechnology Co., Ltd | |
 |
2024-10-29 | 1,2-Dichloroethane
107-06-2
|
US $0.00 / kg | 20kg | 99.0% | 20 tons | Qingdao RENAS Polymer Material Co., Ltd. | |
 |
2023-12-26 | 1,2-Dichloroethane
107-06-2
|
US $100.00-1.00 / KG | 1KG | 99% | g-kg-tons, free sample is available | Henan Fengda Chemical Co., Ltd |
-
- 1,2-Dichloroethane
107-06-2
- US $10.00 / KG
- 99%
- Hebei Weibang Biotechnology Co., Ltd
-
- 1,2-Dichloroethane
107-06-2
- US $0.00 / kg
- 99.0%
- Qingdao RENAS Polymer Material Co., Ltd.
-
- 1,2-Dichloroethane
107-06-2
- US $100.00-1.00 / KG
- 99%
- Henan Fengda Chemical Co., Ltd
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