RESINIFERATOXIN
- CAS No.
- 57444-62-9
- Chemical Name:
- RESINIFERATOXIN
- Synonyms
- RTX;RESINIFERATOXIN;Resiniferatoxin >99%;Resiniferatoxin (80%);Resiniferatoxin, 98.5%;RESINIFERATOXIN,HIGHPURITY;DSDNAKHZNJAGHN-IHCAYWNCSA-N;RESINIFERATOXIN, 99%, HIGH PURITY;RESINIFERATOXIN,EUPHORBIA POISONII;RESINIFERATOXIN AUS EUPHORBIA POISONII
- CBNumber:
- CB7304594
- Molecular Formula:
- C37H40O9
- Molecular Weight:
- 628.71
- MDL Number:
- MFCD00135927
- MOL File:
- 57444-62-9.mol
- MSDS File:
- SDS
Boiling point | 768.7±60.0 °C(Predicted) |
---|---|
Density | 1.35±0.1 g/cm3(Predicted) |
storage temp. | -20°C |
solubility | Soluble in DMSO to 100mM and to 50mM in ethanol |
form | Solid |
pka | 9.85±0.20(Predicted) |
color | White to off-white |
BRN | 5371150 |
Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month. |
FDA UNII | A5O6P1UL4I |
NCI Drug Dictionary | resiniferatoxin |
SAFETY
Risk and Safety Statements
Symbol(GHS) | ![]() ![]() GHS05,GHS06 |
---|---|
Signal word | Danger |
Hazard statements | H315-H319-H335-H301-H314 |
Precautionary statements | P261-P280a-P301+P310a-P405-P501a-P280-P305+P351+P338-P310 |
Hazard Codes | T |
Risk Statements | 25-35 |
Safety Statements | 26-36/37/39-45 |
RIDADR | UN 2928 6.1/PG 2 |
WGK Germany | 3 |
RTECS | CY1633700 |
F | 10-23 |
HazardClass | 6.1(a) |
PackingGroup | II |
HS Code | 29329990 |
RESINIFERATOXIN price More Price(8)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Alfa Aesar | J62458 | Resiniferatoxin, 99+% | 57444-62-9 | 1mg | $374 | 2021-12-16 | Buy |
Cayman Chemical | 11349 | Resiniferatoxin ≥98% | 57444-62-9 | 1mg | $156 | 2021-12-16 | Buy |
Adipogen Life Sciences | AG-CN2-0534-MC01 | Resiniferatoxin ≥98%(HPLC) | 57444-62-9 | 0.1mg | $220 | 2021-12-16 | Buy |
Biosynth Carbosynth | FR45558 | Resiniferatoxin | 57444-62-9 | 1mg | $650 | 2021-12-16 | Buy |
American Custom Chemicals Corporation | TOX0000335 | RESINIFERATOXIN 95.00% | 57444-62-9 | 5MG | $698.65 | 2021-12-16 | Buy |
RESINIFERATOXIN Chemical Properties,Uses,Production
Description
Resiniferatoxin (57444-62-9) is an ultrapotent TRPV1 activator (Ki=43 pM).1 Resiniferatoxin is 100-10,000 fold more potent than capsaicin for most responses yet displays a spectrum of activity distinct from capsaicin.2 A potent sensory neuron excitotoxin.3 Induces a long lasting analgesia in a rodent model of burn pain.4 SEVERE IRRITANT – HANDLE WITH CARE
Chemical Properties
white to off-white solid
Uses
Resiniferatoxin has been used as an agonist to transient receptor potential vanilloid 2 (TRPV2):
- for complex preparation for cryo-electron microscopy structural studies
- to test its effect towards immune responses to?P.?aeruginosa in sensory neurons associated with the cornea
- to study its effects in the denervation of the peripheral sensory nerves in psoriatic mice
Definition
ChEBI: Resiniferatoxin is a heteropentacyclic compound found in Euphorbia poissonii with molecular formula C37H40O9. It is an agonist of the transient receptor potential cation channel subfamily V member 1 (TrpV1). It has a role as a TRPV1 agonist, a plant metabolite, a neurotoxin and an analgesic. It is a diterpenoid, an ortho ester, a tertiary alpha-hydroxy ketone, a member of phenols, a monomethoxybenzene, an organic heteropentacyclic compound, a carboxylic ester and an enone.
Hazard
A poison.
Biological Activity
Ultrapotent analog of capsaicin that is an agonist at vanilloid receptors (K i = 43 pM). Like capsaicin, it acts as a selective modulator of primary afferent neurons. Also available as part of the Vanilloid TRPV1 Receptor Tocriset™ .
Biochem/physiol Actions
Resiniferatoxin (RTX) is an analog of capsaicin. It effectively ablates corneal sensory neurons by activating transient receptor potential vanilloid 1 (TRPV1) channels. RTX facilitates corneal bacterial clearance. It also elicits protective functionality towards cardiac function in a rat model with congestive heart failure (CHF).
References
1) Szolcsanyi et al. (1990), Resiniferatoxin: an ultrapotent selective modulator of capsaicin-sensitive primary afferent neurons; J. Pharmacol. Exp. Ther., 255 923 2) Szallasi and Blumberg (1998), Resiniferatoxin and its analogs provide novel insights into the pharmacology of the vanilloid (capsaicin) receptor; Life Sci. 47 1399 3) Winter et al. (1990) Cellular mechanism of action of resiniferatoxin: a potent sensory neuron excitotoxin; Brain Res. 520 131 4) Salas et al. (2017) Local Resiniferatoxin Induces Long-Lasting Analgesia in a Rat Model of Full Thickness Thermal Injury; Pain Med. 18 2453
RESINIFERATOXIN Preparation Products And Raw materials
Raw materials
Preparation Products
RESINIFERATOXIN Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Finetech Industry Limited | +86-27-87465837 +8618971612321 | info@finetechnology-ind.com | China | 9602 | 58 |
Henan Alfa Chemical Co., Ltd | +8618339805032 | alfa4@alfachem.cn | China | 13185 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
Zibo Hangyu Biotechnology Development Co., Ltd | +86-0533-2185556 +8617865335152 | Mandy@hangyubiotech.com | China | 10977 | 58 |
LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43348 | 58 |
Shanghai Acmec Biochemical Technology Co., Ltd. | +undefined18621343501 | product@acmec-e.com | China | 33350 | 58 |
Shaanxi Cuikang Pharmaceutical Technology Co., Ltd | +86-19164747840 +86-13119157289 | 13119157289@163.com | China | 2972 | 58 |
Shanghai Saikerui Biotechnology Co. , Ltd. | 021-58000709 15900491054 | info@scrbio.com | China | 9268 | 58 |
ChengDu SinoStandards Bio-Tech Co.,Ltd. , | 028-83243028 19136088901 | sinostandards@163.com | China | 4988 | 58 |
J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 94658 | 76 |