yk11
- CAS No.
- 1370003-76-1
- Chemical Name:
- yk11
- Synonyms
- yk1;YK-ll;YK-11-OA;Hot sell;YK11;YK 11;sarms YK11;yk11/mk677;YK-11 powder;YK11-1 gram(44);YK11 White Powder
- CBNumber:
- CB73055372
- Molecular Formula:
- C25H34O6
- Molecular Weight:
- 430.53
- MDL Number:
- MFCD30343804
- MOL File:
- 1370003-76-1.mol
| Melting point | 134-137°C |
|---|---|
| Boiling point | 564.4±50.0 °C(Predicted) |
| Density | 1.22±0.1 g/cm3(Predicted) |
| storage temp. | -20°C Freezer |
| solubility | Chloroform (Slightly), Methanol (Slightly) |
| form | Solid |
| color | White to Pale Yellow |
| InChIKey | KCQHQCDHFVGNMK-PQUNLUOYSA-N |
| FDA UNII | Z9748J6B0R |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS05,GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H315-H318-H334-H317-H341-H361-H370-H413 | |||||||||
| Precautionary statements | P201-P202-P260-P264-P270-P272-P273-P280-P284-P302+P352-P304+P341-P305+P351+P338-P310-P308+P313-P321-P362+P364-P333+P313-P342+P311-P363-P405-P501 | |||||||||
| NFPA 704 |
|
yk11 price More Price(6)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 9003137 | YK-11 | 1370003-76-1 | 10mg | $49 | 2024-03-01 | Buy |
| Cayman Chemical | 9003137 | YK-11 | 1370003-76-1 | 100mg | $263 | 2024-03-01 | Buy |
| Cayman Chemical | 9003137 | YK-11 | 1370003-76-1 | 50mg | $156 | 2024-03-01 | Buy |
| TRC | Y120025 | YK-11(Mixtureofdiasteromers) | 1370003-76-1 | 50mg | $175 | 2021-12-16 | Buy |
| DC Chemicals | DC10809 | YK-11 >98% | 1370003-76-1 | 100mg | $450 | 2021-12-16 | Buy |
yk11 Chemical Properties,Uses,Production
Description
YK11 was first studied by Japanese researcher Yuichiro Kanno in 2011. It was found to be a partial agonist of the androgen receptor (AR), genetically selective, leading researchers to believe the compound was a SARM. YK11 is an experimental drug candidate and an unapproved substance for use in humans.
Uses
YK-11 is a synthetic steroidal selective androgen receptor modulator (SARM).It is a gene-selective partial agonist of the androgen receptor (AR) and does not induce the physical interaction between the NTD/AF1 and LBD/AF2 (known as the N/C interaction), which is required for full transactivation of the AR.
benefits
Better Bones: YK11 works by binding to androgen receptors in the body, which are found in various tissues, including bones. Once attached, it activates genes that promote bone growth and mineralization. It means that YK11 could help individuals with osteoporosis or those looking to improve their bone density. Yk11 may increase bone density and mineralization, leading to stronger and healthier bones. It elevates mobility and reduces the risk of fractures.Inhibits Protein Myostatin: Yk11 plays a role in reducing the levels of a protein called myostatin, which is responsible for limiting muscle growth in the body. Yk11 stimulates the production of follistatin, which inhibits myostatin production. Myostatin acts as a regulator, preventing muscles from growing beyond a certain point.
Mechanism of action
YK-11 is an androgen receptor partial agonist that activates androgen receptor transcriptional activity in HEK293 cells overexpressing androgen receptors when used at a concentration of 0.1 μM.1 It induces expression of the androgen receptor target genes FKBP51 and FGF18 in HEK293 cells when used at a concentration of 10 μM. YK-11 accelerates nuclear translocation of androgen receptors without inducing interaction between the androgen receptor N- and C-termini. In C2C12 cells, YK-11 (500 nM) increases expression of the myogenic regulatory factors MyoD, Myf5, and myogenin, as well as follistatin (Fst), and induces myogenic differentiation.
References
[1] Yuichiro Kanno, et al. Exp Cell Res. Differential DNA-binding and cofactor recruitment are possible determinants of the synthetic steroid YK11-dependent gene expression by androgen receptor in breast cancer MDA-MB 453 cells DOI:10.1016/j.yexcr.2022.113333
[2] Su Jin Lee, et al. Biochem Biophys Res Commun. Myostatin inhibitor YK11 as a preventative health supplement for bacterial sepsis DOI:10.1016/j.bbrc.2021.01.030
[3] Tomofumi Yatsu, et al. Biol Pharm Bull. Selective Androgen Receptor Modulator, YK11, Up-Regulates Osteoblastic Proliferation and Differentiation in MC3T3-E1 Cells DOI:10.1248/bpb.b17-00748
[4] Mario Thevis, et al. Mol Cell Endocrinol. Detection of SARMs in doping control analysis DOI:10.1016/j.mce.2017.01.040
[5] Yuichiro Kanno, et al. Biol Pharm Bull. Selective androgen receptor modulator, YK11, regulates myogenic differentiation of C2C12 myoblasts by follistatin expression DOI:10.1248/BPB.B13-00231
yk11 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10473 | 58 |
| Wuhan Cell Pharmaceutical Co., Ltd | +86-13129979210 +86-13129979210 | sales@cellwh.com | China | 376 | 58 |
| qingdao future trading Co., Ltd | +86-13335044410 +86-13335044410 | cui56813@163.com | China | 110 | 58 |
| Wuhan Ruichi Technology Co., Ltd | +8613545065237 | admin@whrchem.com | China | 153 | 58 |
| Shaanxi Xianhe Biotech Co., Ltd | +8617709210191 | Jerry@xhobio.com | China | 882 | 58 |
| Hebei Mojin Biotechnology Co., Ltd | +86 13288715578 +8613288715578 | sales@hbmojin.com | China | 12834 | 58 |
| Dorne Chemical Technology co. LTD | +86-86-13583358881 +8618560316533 | Ethan@dornechem.com | China | 3096 | 58 |
| Firsky International Trade (Wuhan) Co., Ltd | +8615387054039 | admin@firsky-cn.com | China | 427 | 58 |
| Henan Bao Enluo International TradeCo.，LTD | +86-17331933971 +86-17331933971 | deasea125996@gmail.com | China | 2472 | 58 |
| Xiamen Wonderful Bio Technology Co., Ltd. | +8613043004613 | Sara@xmwonderfulbio.com | China | 283 | 58 |
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- Mar 21，2022
View Lastest Price from yk11 manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-12-23 | YK-11
1370003-76-1
|
US $90.00 / kg | 1kg | 99.9% | 1000 | hebei hongtan Biotechnology Co., Ltd | |
 |
2024-12-23 | YK11 10mg Tablets
1370003-76-1
|
US $0.00-0.00 / Bottle | 1Bottle | 99% | 2000 | Shandong Huizhihan Supply Chain Co., Ltd | |
 |
2024-12-23 | yk11
1370003-76-1
|
US $1.00 / g | 1g | 99% | 100kg | Dorne Chemical Technology co. LTD |
-
- YK-11
1370003-76-1
- US $90.00 / kg
- 99.9%
- hebei hongtan Biotechnology Co., Ltd
-
- YK11 10mg Tablets
1370003-76-1
- US $0.00-0.00 / Bottle
- 99%
- Shandong Huizhihan Supply Chain Co., Ltd
-
- yk11
1370003-76-1
- US $1.00 / g
- 99%
- Dorne Chemical Technology co. LTD