ChemicalBook >> CAS DataBase List >>YKL-5-124

YKL-5-124

CAS No.
1957203-01-8
Chemical Name:
YKL-5-124
Synonyms
YKL-5-124;YKL-5-124, 10 mM in DMSO;(S)-3-(4-Acrylamidobenzamido)-N-(2-(dimethylamino)-1-phenylethyl)-6,6-dimethyl-4,6-dihydropyrrolo[3,4-c]pyrazole-5(1H)-carboxamide;Pyrrolo[3,4-c]pyrazole-5(1H)-carboxamide, N-[(1S)-2-(dimethylamino)-1-phenylethyl]-4,6-dihydro-6,6-dimethyl-3-[[4-[(1-oxo-2-propen-1-yl)amino]benzoyl]amino]-;T-loop,phosphorylation,inhibit,arrest,CDK7,Inhibitor,CDK,YKL5124,YKL 5 124,CDK7/Mat1/CycH,Cyclin dependent kinase,cell-cycle,transcription,Pol-II,irreversible,covalent
CBNumber:
CB85867444
Molecular Formula:
C28H33N7O3
Molecular Weight:
515.61
MDL Number:
MFCD34469131
MOL File:
1957203-01-8.mol
Last updated:2025-01-27 09:38:02

YKL-5-124 Properties

Boiling point 706.1±60.0 °C(Predicted)
Density 1.284±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO : 250 mg/mL (484.86 mM; Need ultrasonic)
pka 12.78±0.40(Predicted)
form Solid
color White to off-white
UNSPSC Code 12352107
NACRES NA.77

YKL-5-124 price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich SML3039 YKL-5-124 ≥98% (HPLC) 1957203-01-8 5MG $113 2024-03-01 Buy
Sigma-Aldrich SML3039 YKL-5-124 ≥98% (HPLC) 1957203-01-8 25MG $568 2024-03-01 Buy
Product number Packaging Price Buy
SML3039 5MG $113 Buy
SML3039 25MG $568 Buy

YKL-5-124 Chemical Properties,Uses,Production

Biological Activity

YKL-5-124 is a potent, selective, irreversible and covalent CDK7 inhibitor with IC50s of 53.5 nM and 9.7 nM for CDK7 and CDK7/Mat1/CycH, respectively. YKL-5-124 is >100-fold greater selective for CDK7 than CDK9 and CDK2, and inactive against CDK12 and CDK13. YKL-5-124 induces a strong cell-cycle arrest, inhibits E2F-driven gene expression, and exhibits little effect on RNA polymerase II phosphorylation status[1]. YKL-5-124 (0-2000 nM; 72 hours; HAP1 cells) treatment causes a dose-dependent increase in G1- and G2/M-phase cells and a corresponding loss of S-phase cells[1].YKL-5-124 (0-2000 nM; 24 hours; HAP1 WT cells) treatment inhibits CDK1 T-loop phosphorylation, and to a lesser extent CDK2 T-loop phosphorylation in a concentration-dependent fashion[1].Treatment of cells with YKL-5-124 as a competitor at a concentration of about 30 nM blocks pull-down of CDK7-cyclin H but has no effect on the pull-down of cyclin K-CDK12/13 in HAP1 cells. Treatment with 100 nM YKL-5-124 reduces CDK7-cyclin H binding to bioTHZ1 by >50% at 30 min[1].

storage

Store at -20°C

References

[1]. Olson CM, et al. Development of a Selective CDK7 Covalent Inhibitor Reveals Predominant Cell-Cycle Phenotype. Cell Chem Biol. 2019 Jun 20;26(6):792-803.e10.

YKL-5-124 Preparation Products And Raw materials

Raw materials

Preparation Products

YKL-5-124 Suppliers

Global( 26)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32161 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD
86-571-88216897,88216896 13588875226 sales@hzclap.com CHINA 6312 58
Nantong HI-FUTURE Biology Co., Ltd.
+undefined18051384581 sales@chemhifuture.com China 3135 58
Wuhan Topule Biopharmaceutical Co., Ltd
+8618327326525 masar@topule.com China 8467 58
Aladdin Scientific
tp@aladdinsci.com United States 52924 58
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627 info@efebio.com China 9804 58
ShangHai Biochempartner Co.,Ltd 17754423994 17754423994 2853530910@QQ.com China 8011 62
DC Chemicals 021-58447131 13564518121 sales@dcchemicals.com China 9409 58
Nantong Hi-Future Biotechnology Co., Ltd 18051384581 sales@chemhifuture.com China 3021 58
SINO High Goal Chemical Technology Co., Ltd. 021-57646680 18306277365 guoxin@chembiobanksh.com China 2573 58

View Lastest Price from YKL-5-124 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
YKL-5-124 pictures 2024-11-19 YKL-5-124
1957203-01-8
US $97.00-198.00 / mg 99.5% 10g TargetMol Chemicals Inc.
  • YKL-5-124 pictures
  • YKL-5-124
    1957203-01-8
  • US $97.00-198.00 / mg
  • 99.5%
  • TargetMol Chemicals Inc.
YKL-5-124 Pyrrolo[3,4-c]pyrazole-5(1H)-carboxamide, N-[(1S)-2-(dimethylamino)-1-phenylethyl]-4,6-dihydro-6,6-dimethyl-3-[[4-[(1-oxo-2-propen-1-yl)amino]benzoyl]amino]- (S)-3-(4-Acrylamidobenzamido)-N-(2-(dimethylamino)-1-phenylethyl)-6,6-dimethyl-4,6-dihydropyrrolo[3,4-c]pyrazole-5(1H)-carboxamide T-loop,phosphorylation,inhibit,arrest,CDK7,Inhibitor,CDK,YKL5124,YKL 5 124,CDK7/Mat1/CycH,Cyclin dependent kinase,cell-cycle,transcription,Pol-II,irreversible,covalent YKL-5-124, 10 mM in DMSO 1957203-01-8 C28H33N7O3
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