ChemicalBook >> CAS DataBase List >>GSK-A1
GSK-A1
- CAS No.
- 1416334-69-4
- Chemical Name:
- GSK-A1
- Synonyms
- GSK-A1;PI4KA inhibitor-A1;5-{2-Amino-1-[4-(4-morpholinyl)phenyl]-1H-benzimidazol-6-yl}-N-(2-fluorophenyl)-2-methoxy-3-pyridinesulfonamide;3-Pyridinesulfonamide, 5-[2-amino-1-[4-(4-morpholinyl)phenyl]-1H-benzimidazol-6-yl]-N-(2-fluorophenyl)-2-methoxy-;PtdIns(4,5)P2,PI4KIIIα,inhibit,Hepatitis C virus,PI4K,GSK A1,GSK-A1,Phosphatidylinositol 4 kinases,PtdIns(4)P,phosphatidylinositol 4-kinase PI4KA,HCV,Inhibitor,PI4 kinases,GSKA1,GSK-A-1
- CBNumber:
- CB73067551
- Molecular Formula:
- C29H27FN6O4S
- Molecular Weight:
- 574.63
- MDL Number:
- MFCD29770784
- MOL File:
- 1416334-69-4.mol
Last updated:2024-07-02 08:55:16
GSK-A1 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Adipogen Life Sciences | SYN-1219-M001 | GSK-A1 ≥95% | 1416334-69-4 | 1mg | $130 | 2021-12-16 | Buy |
| AK Scientific | SYN1219 | GSK-A1 | 1416334-69-4 | 50mg | $1270 | 2021-12-16 | Buy |
| DC Chemicals | DC10061 | PI4KAinhibitor-A1 >98% | 1416334-69-4 | 250mg | $1300 | 2021-12-16 | Buy |
| DC Chemicals | DC10061 | PI4KAinhibitor-A1 >98% | 1416334-69-4 | 1g | $2700 | 2021-12-16 | Buy |
GSK-A1 Chemical Properties,Uses,Production
Biological Activity
GSK-A1 is an inhibitor of phosphatidylinositol 4-kinase IIIα (PI4KIIIα; IC50 = 3.16 nM).1 It is selective for PI4KIIIα over PI4KIIIβ, PI3Kα, PI3Kβ, and PI3Kδ (IC50s = >50 nM) but also inhibits PI3Kγ (IC50 = 15.8 nM). GSK-A1 decreases the levels of phosphatidylinositol 4-phosphate (PtdIns-(4)-P1) but not PtdIns-(4,5)-P2 in HEK293 cells expressing the angiotensin II type 1 (AT1) receptor (IC50 = 3 nM). GSK-A1 inhibits hepatitis C virus (HCV) genotype 1a and 1b replication.
References
1.Bojjireddy, N., Botyanszki, J., Hammond, G., et al.Pharmacological and genetic targeting of the PI4KA enzyme reveals its important role in maintaining plasma membrane phosphatidylinositol 4-phosphate and phosphatidylinositol 4,5-bisphosphate levelsJ. Biol. Chem.289(9)6120-6132(2014)
GSK-A1 Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 37)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32957 | 60 |
| Biochempartner | 0086-13720134139 | candy@biochempartner.com | CHINA | 965 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32165 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6312 | 58 |
| Nextpeptide Inc | +86-0571-81612335 +8613336028439 | sales@nextpeptide.com | China | 19908 | 58 |
| Nantong HI-FUTURE Biology Co., Ltd. | +undefined18051384581 | sales@chemhifuture.com | China | 3135 | 58 |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8467 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 52925 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131957 | 58 |
| Pharmacodia (Beijing) Co.,Ltd | +86-400-851-9921 | sales@pharmacodia.com | China | 2317 | 55 |
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1of4
GSK-A1
PI4KA inhibitor-A1
3-Pyridinesulfonamide, 5-[2-amino-1-[4-(4-morpholinyl)phenyl]-1H-benzimidazol-6-yl]-N-(2-fluorophenyl)-2-methoxy-
5-{2-Amino-1-[4-(4-morpholinyl)phenyl]-1H-benzimidazol-6-yl}-N-(2-fluorophenyl)-2-methoxy-3-pyridinesulfonamide
PtdIns(4,5)P2,PI4KIIIα,inhibit,Hepatitis C virus,PI4K,GSK A1,GSK-A1,Phosphatidylinositol 4 kinases,PtdIns(4)P,phosphatidylinositol 4-kinase PI4KA,HCV,Inhibitor,PI4 kinases,GSKA1,GSK-A-1
1416334-69-4
C29H27FN6O4S