Mito-TEMPO
- CAS No.
- 1569257-94-8
- Chemical Name:
- Mito-TEMPO
- Synonyms
- Mito-TEMPO (hydrate);2,2,6,6-tetramethyl-4-[[2-(triphenylphosphonio)acetyl]amino]-1-piperidinyloxy,monochloride,monohydrate;[2-[(1-$l^{1}-oxidanyl-2,2,6,6-tetramethylpiperidin-4-yl)amino]-2-oxoethyl]-triphenylphosphanium:chloride:hydrate
- CBNumber:
- CB73136756
- Molecular Formula:
- C29H37ClN2O3P*
- Molecular Weight:
- 528.042
- MDL Number:
- MOL File:
- 1569257-94-8.mol
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P304+P340-P305+P351+P338-P312-P337+P313-P403+P233-P405-P501 | |||||||||
| NFPA 704 |
|
Mito-TEMPO price More Price(5)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 16621 | Mito-TEMPO (hydrate) ≥95% | 1569257-94-8 | 1mg | $32 | 2024-03-01 | Buy |
| Cayman Chemical | 16621 | Mito-TEMPO (hydrate) ≥95% | 1569257-94-8 | 5mg | $70 | 2024-03-01 | Buy |
| Cayman Chemical | 16621 | Mito-TEMPO (hydrate) ≥95% | 1569257-94-8 | 10mg | $120 | 2024-03-01 | Buy |
| Cayman Chemical | 16621 | Mito-TEMPO (hydrate) ≥95% | 1569257-94-8 | 25mg | $267 | 2024-03-01 | Buy |
| AK Scientific | 6732DW | CID73504624 | 1569257-94-8 | 1mg | $133 | 2021-12-16 | Buy |
Mito-TEMPO Chemical Properties,Uses,Production
Description
MitoTEMPO is a mitochondria-targeted superoxide dismutase mimetic that possesses superoxide and alkyl radical scavenging properties.1 This compound combines the antioxidant piperidine nitroxide TEMPO with the lipophilic cation triphenylphosphonium, which allows it to pass through lipid bilayers and accumulate in mitochondria.1 Mitochondrial targeting of superoxide scavenging via mitoTEMPO has been examined for potential therapeutic benefit to a variety of mitochondrial dysfunctions arising from excessive reactive oxygen species.2,3,4
References
1. Dikalov, S. Cross talk between mitochondria and NADPH oxidases Free Radic. Biol. Med. 51(7),1289-1301(2011).
2. Liang, H.L., Arsenault, J., Mortensen, J., et al. Partial attenuation of cytotoxicity and apoptosis by SOD1 in ischemic renal epithelial cells Apoptosis 14(10),1176-1189(2009).
3. Dikalova, A.E., Bikineyeva, A.T., Budzyn, K., et al. Therapeutic targeting of mitochondrial superoxide in hypertension Circ. Res. 107(1),106-116(2010).
4. Liang, H.L., Sedlic, F., Bosnjak, Z., et al. SOD1 and MitoTEMPO partially prevent mitochondrial permeability transition pore opening, necrosis, and mitochondrial apoptosis after ATP depletion recovery Free Radic. Biol. Med. 49(10),1550-1560(2010).
Mito-TEMPO Preparation Products And Raw materials
Raw materials
Preparation Products
Mito-TEMPO Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9707 | 58 |
| Tianjin Kailiqi Biotechnology Co., Ltd. | 15076683720 | klq@cw-bio.com | China | 3730 | 55 |
| Shanghai Hongye Biotechnology Co. Ltd | 400-9205774 | sales@glpbio.cn | China | 6870 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11289 | 58 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 23963 | 58 |
| Shanghai Yiyan Biotechnology Co. , Ltd. | 021-69985186 13611928337 | 3427709316@qq.com | China | 7980 | 58 |
| Shanghai Aladdin Biochemical Technology Co.,Ltd. | +86-18521732826 | market@aladdin-e.com | China | 48467 | 58 |