ChemicalBook >> CAS DataBase List >>5,7-Dichloro-1,2,3,4-Tetrahydroisoquinoline-6-Carboxylic Acid Hydrochloride
5,7-Dichloro-1,2,3,4-Tetrahydroisoquinoline-6-Carboxylic Acid Hydrochloride
- CAS No.
- 1289646-93-0
- Chemical Name:
- 5,7-Dichloro-1,2,3,4-Tetrahydroisoquinoline-6-Carboxylic Acid Hydrochloride
- Synonyms
- 5,7-dichloro-1,2,3,4-tetrahydroisoquinoline-6-carboxylic acid hydrochloride;6-Isoquinolinecarboxylic acid, 5,7-dichloro-1,2,3,4-tetrahydro-, hydrochloride;Lifitegrast Impurity 5;lifitegrast-impurity IV-3;Lifitegrast Intermediate 2;Litakast Impurity 20 (hydrochloride);6-ISOQUINOLINECARBOXYLIC ACID,5,7-DICHLORO-1,2,3,4-TETRAHYDR...;5,7-Dichloro-1,2,3,4-tetrahydro-6-isoquinolinecarboxylic acid hydrochloride (1:1);6-Isoquinolinecarboxylic acid, 5,7-dichloro-1,2,3,4-tetrahydro-, hydrochloride (1;6-Isoquinolinecarboxylic acid, 5,7-dichloro-1,2,3,4-tetrahydro-, hydrochloride (1:1)
- CBNumber:
- CB73137955
- Molecular Formula:
- C10H10Cl3NO2
- Molecular Weight:
- 282.55
- MDL Number:
- MFCD31556162
- MOL File:
- 1289646-93-0.mol
Last updated:2023-07-12 10:41:40
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
5,7-Dichloro-1,2,3,4-Tetrahydroisoquinoline-6-Carboxylic Acid Hydrochloride price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| AK Scientific | 8781EL | 5,7-Dichloro-1,2,3,4-tetrahydroisoquinoline-6-carboxylicacidhydrochloride | 1289646-93-0 | 1g | $532 | 2021-12-16 | Buy |
| AK Scientific | 8781EL | 5,7-Dichloro-1,2,3,4-tetrahydroisoquinoline-6-carboxylicacidhydrochloride | 1289646-93-0 | 10g | $2085 | 2021-12-16 | Buy |
5,7-Dichloro-1,2,3,4-Tetrahydroisoquinoline-6-Carboxylic Acid Hydrochloride Chemical Properties,Uses,Production
Uses
6-Isoquinolinecarboxylic acid, 5,7-dichloro-1,2,3,4-tetrahydro-, hydrochloride (1:1) is a quinoline derivative used in pharmaceutical synthesis.
General Description
5,7-Dichloro-1,2,3,4-Tetrahydroisoquinoline-6-Carboxylic Acid Hydrochloride, also known as Lifitegrast Impurity 5, is an impurity of Lifitegrast. Lifitegrast is a FDA approved drug for the treatment of keratoconjunctivitis sicca (dry eye syndrome). It is a tetrahydroisoquinoline derivative and lymphocyte function-associated antigen-1 ( LFA-1) antagonist that was discovered through the rational design process.
Synthesis of 5,7-Dichloro-1,2,3,4-Tetrahydroisoquinoline-6-Carboxylic Acid Hydrochloride from 5,7-dichloro-2-trityl-1,2,3,4-tetrahydroisoquinoline-6-carboxylic acid
5,7-Dichloro-1,2,3,4-Tetrahydroisoquinoline-6-Carboxylic Acid Hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 100)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| PharmOrgSyn Laboratories Co., Ltd. | +86-021-38228826 +86-13916602830 | sales@pharmorgsyn.cn | China | 140 | 58 |
| Guangzhou Tosun Pharmaceutical Limited | +8618922120635 | sales@toref-standards.com | China | 998 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29791 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29880 | 58 |
| Hangzhou Cyanochem Co., Ltd. | +86 17788583750 | sales@cyanochem.com | CHINA | 281 | 58 |
| Accela ChemBio Inc. | +1-858-6993322 | info@accelachem.com | United States | 17777 | 58 |
| Chengdu Pukang Biotechnology Co., Ltd | 028-82550498 | export@pu-kang.com | CHINA | 210 | 58 |
| Standardpharm Co. Ltd. | 86-714-3992388 | overseasales1@yongstandards.com | United States | 14332 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | sales@chemdad.com | China | 39894 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
View Lastest Price from 5,7-Dichloro-1,2,3,4-Tetrahydroisoquinoline-6-Carboxylic Acid Hydrochloride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-04-11 | Lifitegrast Impurity 5
1289646-93-0
|
US $0.00-0.00 / mg | 10mg | 98.49% | 10g/month | Guangzhou Tosun Pharmaceutical Limited | |
 |
2019-07-06 | Lifitegrast Intermediate 2
1289646-93-0
|
US $1.00 / KG | 1KG | 98% | 100KG | Career Henan Chemical Co |
-
- Lifitegrast Impurity 5
1289646-93-0
- US $0.00-0.00 / mg
- 98.49%
- Guangzhou Tosun Pharmaceutical Limited
-
- Lifitegrast Intermediate 2
1289646-93-0
- US $1.00 / KG
- 98%
- Career Henan Chemical Co
1289646-93-0(5,7-Dichloro-1,2,3,4-Tetrahydroisoquinoline-6-Carboxylic Acid Hydrochloride)Related Search:
Lifitegrast Impurity 6
Lifitegrast Impurity 3
Lifitegrast Impurity 9 HCl
Lifitegrast Impurity 8
2(1H)-Isoquinolinecarboxylic acid, 5,7-dichloro-3,4-dihydro-6-[[[(1S)-1-[[3-(methylsulfonyl)phenyl]methyl]-2-oxo-2-(phenylmethoxy)ethyl]amino]carbonyl]-, 1,1-dimethylethyl ester
lifitegrast
benzyl (S)-2-(2-(benzofuran-6-carbonyl)-5,7-dichloro-1,2,3,4-tetrahydroisoquinoline-6-carboxamido)-3-(3-(methylsulfonyl)phenyl)propanoate
(R)-Benzyl 2-amino-3-(3-(methylsulfonyl)phenyl)propanoate hydrochloride
Ethyl benzofuran-6-carboxylate
L-Phenylalanine, N-[(5,7-dichloro-1,2,3,4-tetrahydro-6-isoquinolinyl)carbonyl]-3-(methylsulfonyl)-, phenylmethyl ester, hydrochloride (1:1)
1of3
6-Isoquinolinecarboxylic acid, 5,7-dichloro-1,2,3,4-tetrahydro-, hydrochloride (1:1)
6-Isoquinolinecarboxylic acid, 5,7-dichloro-1,2,3,4-tetrahydro-, hydrochloride (1
Lifitegrast Intermediate 2
Lifitegrast Impurity 5
5,7-Dichloro-1,2,3,4-tetrahydro-6-isoquinolinecarboxylic acid hydrochloride (1:1)
lifitegrast-impurity IV-3
6-ISOQUINOLINECARBOXYLIC ACID,5,7-DICHLORO-1,2,3,4-TETRAHYDR...
6-Isoquinolinecarboxylic acid, 5,7-dichloro-1,2,3,4-tetrahydro-, hydrochloride
5,7-dichloro-1,2,3,4-tetrahydroisoquinoline-6-carboxylic acid hydrochloride
Litakast Impurity 20 (hydrochloride)
1289646-93-0