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AlPhos

CAS No.
1805783-60-1
Chemical Name:
AlPhos
Synonyms
6-Methoxy-2-{2,4,6-tri-i-propyl-3-[(2,3,5,6-tetrafluoro-4-butyl;3',1''-terphenyl]-2-yl]bis(tricyclo[3.3.1.1(3,7)]dec-1-yl)phosphine;6-Methoxy-2-{2,4,6-tri-i-propyl-3-[(2,3,5,6-tetrafluoro-4-butyl,AlPhos;[4''-Butyl-2'',3'',5'',6''-tetrafluoro-3-methoxy-2',4',6'-tris(1-methylethyl)[1,1';2-(Diadamantylphosphino)-3-methoxy-2,4,6-tri-i-propyl-3-(2,3,5,6-tetrafluoro-4-butylphenyl)-1,1-biph;6-Methoxy-2-{2,4,6-tri-i-propyl-3-[(2,3,5,6-tetrafluoro-4-butyl)phenyl]phenyl}diadamantylphosphine,98%;6-Methoxy-2-{2,4,6-tri-i-propyl-3-[(2,3,5,6-tetrafluoro-4-butyl )phenyl]phenyl}diadamantyl phosphine, 98%;6-Methoxy-2-{2,4,6-tri-i-propyl-3-[(2,3,5,6-tetrafluoro-4-butyl )phenyl]phenyl}diadamantyl phosphine, AlPhos;2-(Diadamantylphosphino)-3-methoxy-2',4',6'-tri-i-propyl-3'-(2,3,5,6-tetrafluoro-4-butylphenyl)-1,1'-biphenyl;2-(DIADAMANTYLPHOSPHINO)-3-METHOXY-2,4,6-TRI-I-PROPYL-3-(2,3,5,6-TETRAFLUORO-4-BUTYLPHENYL)-1,1-BIPHENYLALPHOS
CBNumber:
CB73139858
Molecular Formula:
C52H67F4OP
Molecular Weight:
815.06
MDL Number:
MFCD29905023
MOL File:
1805783-60-1.mol
Last updated:2024-06-07 14:57:24

AlPhos Properties

Melting point 218-223 °C
form Powder
color white to yellow
Sensitive air sensitive
InChIKey ALWIRDZSIXWCBO-UHFFFAOYSA-N
SMILES P(C1=C(OC)C=CC=C1C1=C(C(C)C)C=C(C(C)C)C(C2=C(F)C(F)=C(CCCC)C(F)=C2F)=C1C(C)C)(C12CC3CC(CC(C3)C1)C2)C12CC3CC(CC(C3)C1)C2

AlPhos price More Price(5)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 799718 AlPhos 1805783-60-1 100MG $167 2023-06-20 Buy
Strem Chemicals 15-2065 2-(Diadamantylphosphino)-3-methoxy-2,4,6-tri-i-propyl-3-(2,3,5,6-tetrafluoro-4-butylphenyl)-1,1-biphenyl AlPhos 1805783-60-1 100mg $114 2024-03-01 Buy
Strem Chemicals 15-2065 2-(Diadamantylphosphino)-3-methoxy-2,4,6-tri-i-propyl-3-(2,3,5,6-tetrafluoro-4-butylphenyl)-1,1-biphenyl AlPhos 1805783-60-1 500mg $453 2024-03-01 Buy
Strem Chemicals 15-2065 2-(Diadamantylphosphino)-3-methoxy-2,4,6-tri-i-propyl-3-(2,3,5,6-tetrafluoro-4-butylphenyl)-1,1-biphenyl AlPhos 1805783-60-1 2g $1358 2024-03-01 Buy
Arctom AS678675 6-Methoxy-2-{2,4,6-tri-i-propyl-3-[(2,3,5,6-tetrafluoro-4-butyl)phenyl]phenyl}diadamantylphosphine 1805783-60-1 250mg $473 2021-12-16 Buy
Product number Packaging Price Buy
799718 100MG $167 Buy
15-2065 100mg $114 Buy
15-2065 500mg $453 Buy
15-2065 2g $1358 Buy
AS678675 250mg $473 Buy

AlPhos Chemical Properties,Uses,Production

Reaction

  1. Ligand for the Palladium-Catalyzed Fluorination of Five-Membered Heteroaryl Bromides
  2. Ligand for the Palladium-Catalyzed Fluorination of Aryl Triflates and Bromides
Reactions of 1805783-60-1

Uses

AlPhos is used in the selective arylation of aminophenylalanine in unprotected peptides with organometallic palladium reagents.

General Description

AlPhos is a versatile, highly efficient ligand used extensively in various important organic transformations. Recognized for its unique structure and attributes, AlPhos serves as an impressive catalyst that enables several key synthetic processes. It is primarily used in the following coupling reactions: Buchwald-Hartwig cross coupling, Suzuki-Miyaura coupling, Stille coupling, Sonogashira coupling, Negishi coupling, Heck coupling, Hiyama coupling reaction. With its remarkable performance across these reactions, AlPhos represents an invaluable tool in preparing and producing pharmaceuticals, agrochemicals, and polymers.

AlPhos Preparation Products And Raw materials

Raw materials

Preparation Products

AlPhos Suppliers

Global( 27)Suppliers
Supplier Tel Email Country ProdList Advantage
XINXIANG RUNYU MATERIAL CO., LTD.
+86-13592593621; +8613592593621 sales@runvmat.com China 428 58
Aladdin Scientific
+1-+1(833)-552-7181 sales@aladdinsci.com United States 52927 58
Richest Group Ltd
18017061086 oled@richest-group.com CHINA 5601 58
Hangzhou MolCore BioPharmatech Co.,Ltd.
+86-057181025280; +8617767106207 sales@molcore.com China 49739 58
Shaoxin Catsyn Co., Ltd.
+undefined-0575-82040869 +86-0575-82040869; sales@catsyn.com China 6116 58
Sinocompound Catalysts Co., Ltd. 0512-67216630 18962121273 sales@sinocompound.com China 279 64
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. 025-66113011 18112977050 cb6@aikonchem.com China 16687 50
Xinxiang Runyu Material Co., Ltd. 166-166-37336996 15690792173 chenxi.song@runvmat.com China 459 55
Sigma-Aldrich 021-61415566 800-8193336 orderCN@merckgroup.com China 51471 80
Zhengzhou Kingorgchem Chemical Technology Co., Ltd.gy Co., Ltd. 0371-0371-65511006 18625597674 sales@kingorgchem.com China 953 55
[4''-Butyl-2'',3'',5'',6''-tetrafluoro-3-methoxy-2',4',6'-tris(1-methylethyl)[1,1':3',1''-terphenyl]-2-yl]bis(tricyclo[3.3.1.1(3,7)]dec-1-yl)phosphine 6-Methoxy-2-{2,4,6-tri-i-propyl-3-[(2,3,5,6-tetrafluoro-4-butyl )phenyl]phenyl}diadamantyl phosphine, 98% AlPhos 6-Methoxy-2-{2,4,6-tri-i-propyl-3-[(2,3,5,6-tetrafluoro-4-butyl )phenyl]phenyl}diadamantyl phosphine, 98% 2-(DIADAMANTYLPHOSPHINO)-3-METHOXY-2,4,6-TRI-I-PROPYL-3-(2,3,5,6-TETRAFLUORO-4-BUTYLPHENYL)-1,1-BIPHENYLALPHOS 6-Methoxy-2-{2,4,6-tri-i-propyl-3-[(2,3,5,6-tetrafluoro-4-butyl )phenyl]phenyl}diadamantyl phosphine, AlPhos [4''-Butyl-2'',3'',5'',6''-tetrafluoro-3-methoxy-2',4',6'-tris(1-methylethyl)[1,1' 3',1''-terphenyl]-2-yl]bis(tricyclo[3.3.1.1(3,7)]dec-1-yl)phosphine bis(1-adamantyl)-[2-[3-(4-butyl-2,3,5,6-tetrafluorophenyl)-2,4,6-tri(propan-2-yl)phenyl]-6-methoxyphenyl]phosphane 6-Methoxy-2-{2,4,6-tri-i-propyl-3-[(2,3,5,6-tetrafluoro-4-butyl Phosphine, [4''-butyl-2'',3'',5'',6''-tetrafluoro-3-methoxy-2',4',6'-tris(1-methylethyl)[1,1':3',1''-terphenyl]-2-yl]bis(tricyclo[3.3.1.13,7]dec-1-yl)- 2-(Diadamantylphosphino)-3-methoxy-2',4',6'-tri-i-propyl-3'-(2,3,5,6-tetrafluoro-4-butylphenyl)-1,1'-biphenyl 2-(Diadamantylphosphino)-3-methoxy-2,4,6-tri-i-propyl-3-(2,3,5,6-tetrafluoro-4-butylphenyl)-1,1-biph 6-Methoxy-2-{2,4,6-tri-i-propyl-3-[(2,3,5,6-tetrafluoro-4-butyl,AlPhos 6-Methoxy-2-{2,4,6-tri-i-propyl-3-[(2,3,5,6-tetrafluoro-4-butyl)phenyl]phenyl}diadamantylphosphine,98% 1805783-60-1 C52H67F4OP Buchwald Ligands Series Buchwald Ligands&Precatalysts Achiral Phosphine Aryl Phosphine