Ginsenoside Rg1
- CAS No.
- 22427-39-0
- Chemical Name:
- Ginsenoside Rg1
- Synonyms
- Rg1;SANCHINOSIDE C1;PANAXOSIDE A;ginsenosidea2;ginsenosideg1;panaxosiderg1;Gensenoside Rg1;GINSENOSIDE RGL;GINSENOSIDE RG1;Panaxsaponin Rg1
- CBNumber:
- CB7331840
- Molecular Formula:
- C42H72O14
- Molecular Weight:
- 801.01
- MDL Number:
- MFCD00210293
- MOL File:
- 22427-39-0.mol
| Melting point | 194～197℃ |
|---|---|
| Boiling point | 898.5±65.0 °C(Predicted) |
| Density | 1.33±0.1 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Store in freezer, under -20°C |
| solubility | DMSO (Slightly), Methanol (Slightly), Pyridine (Slightly) |
| pka | 12.91±0.70(Predicted) |
| form | Solid |
| color | White to Off-White |
| biological source | Panax notoginseng (Burk.) F.H.Chen |
| Stability | Hygroscopic |
| InChIKey | YURJSTAIMNSZAE-OLCOBRLXNA-N |
| LogP | 1.670 (est) |
| CAS DataBase Reference | 22427-39-0(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
| FDA UNII | PJ788634QY |
| UNSPSC Code | 85151701 |
| NACRES | NA.24 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302 | |||||||||
| Precautionary statements | P264-P270-P301+P312+P330-P501 | |||||||||
| Hazard Codes | Xn,T,F | |||||||||
| Risk Statements | 22-39/23/24/25-23/24/25-11 | |||||||||
| Safety Statements | 2-45-36/37-16-7-24/25 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | LY9537200 | |||||||||
| HS Code | 29389090 | |||||||||
| NFPA 704 |
|
Ginsenoside Rg1 price More Price(49)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | PHR2200 | Ginsenoside Rg1 certified reference material, pharmaceutical secondary standard | 22427-39-0 | 50MG | $223 | 2024-03-01 | Buy |
| Sigma-Aldrich | 1291672 | Ginsenoside Rg1 United States Pharmacopeia (USP) Reference Standard | 22427-39-0 | 20mg | $344 | 2024-03-01 | Buy |
| Sigma-Aldrich | 00370580 | Ginsenoside Rg1 primary pharmaceutical reference standard | 22427-39-0 | 10mg | $766 | 2024-03-01 | Buy |
| Cayman Chemical | 15315 | Ginsenoside Rg1 ≥98% | 22427-39-0 | 1mg | $37 | 2024-03-01 | Buy |
| Cayman Chemical | 15315 | Ginsenoside Rg1 ≥98% | 22427-39-0 | 5mg | $127 | 2024-03-01 | Buy |
Ginsenoside Rg1 Chemical Properties,Uses,Production
Description
Ginsenoside RG1(Rg1) is a natural product found in Panax notoginseng, Panax ginseng, and Panax vietnamensis. It is one of the primary bioactive ingredients in Panax notoginseng saponins. Numerous studies have indicated that Rg1 plays significant roles in health benefits such as anticancer, neuroprotective, anti-senescence, anti-inflammation, and antioxidative effects. Also, extensive research has demonstrated that Rg1 is associated with various diseases, including cardiovascular disease, Alzheimer’s disease, spinal cord injury, and liver injury. Xue et al. and Yu et al. demonstrated that Rg1 ameliorated streptozotocin-induced oxidative stress and myocardial apoptosis and suppressed HG-induced mesenchymal activation and fibrosis[1].
Chemical Properties
White solid
Uses
Ginsenoside Rg1 protects against arthitis through osteoclast differentiation inhibition. Anti-tumor agent, inhibits the NF-kB-dependant MMP-expression in PMA (phorbol myristate acetate)-induced tumor cell invasion.
Definition
ChEBI: A ginsenoside found in Panax ginseng and Panax japonicus var. major that is dammarane which is substituted by hydroxy groups at the 3beta, 6alpha, 12beta and 20 <ital pro-S positions, in which the hydroxy groups at positions 6 and 20 have been converted to the corresponding beta-D-glucopyranosides, and in which a double bond has been introduced at the 24-25 posit on.
in vivo
In the inflamed joints of adjuvant-induced arthritis (AIA) rats, the level of p-IκBα and p-p65 is significantly higher than in controls and PPAR-γ levels are significantly lower. Treatment with Ginsenoside Rg1 in vivo inhibits IκBα phosphorylation, reduces NF-κB nuclear translocation and upregulates PPAR-γ expression[2]. Ginsenoside Rg1 (G-Rg1) and Ginsenoside Rg2 (G-Rg2) reduce the escape latencies on the last two training days compared to the Alzheimer's disease (AD) model group (p<0.05). In the spatial exploration test, the total time spent in the target quadrant and the number of mice that exactly crossed the previous position of the platform are clearly shorter and lower, respectively, in the AD model group mice than in the normal control group mice (p<0.01), a trend that is reversed by treatment with Ginsenoside Rg1 and Ginsenoside Rg2 (Ginsenoside Rg1, p<0.01; Ginsenoside Rg2, p<0.05). Treatment with Ginsenoside Rg1 and Ginsenoside Rg2 effectively improve cognitive function of the mice that have declined due to AD. Ginsenoside Rg1 and Ginsenoside Rg2 reduce Aβ1-42 accumulation in APP/PS1 mice. In the Ginsenoside Rg1 and Ginsenoside Rg2 treated mice, the pathological abnormalities observed in the APP/PS1 mice are gradually ameliorated. Clear nucleoli and light brown, sparsely scattered Aβ deposits are visible[1].
IC 50
Aβ1-42; p65
References
[1] Hui Liu. “Ginsenoside Rg1 attenuates the inflammation and oxidative stress induced by diabetic nephropathy through regulating the PI3K/AKT/FOXO3 pathway.” Annals of translational medicine 9 24 (2021): 1789.
Ginsenoside Rg1 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shaanxi Cuikang Pharmaceutical Technology Co., Ltd | +8618791163155 | 18791163155@163.com | China | 3558 | 58 |
| Shaanxi Haibo Biotechnology Co., Ltd | +undefined18602966907 | qinhe02@xaltbio.com | China | 997 | 58 |
| BINBO BIOLOGICAL CO.,LTD | +8618629063126 | info@binbobiological.com | China | 452 | 58 |
| HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD | +8615350851019 | admin@86-ss.com | China | 1001 | 58 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-371-+86-371-66670886 | info@dakenam.com | China | 19805 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21628 | 55 |
| Shanghai Zheyan Biotech Co., Ltd. | 18017610038 | zheyansh@163.com | CHINA | 3619 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29858 | 58 |
| Chengdu GLP biotechnology Co Ltd | 028-87075086 13350802083 | scglp@glp-china.com | CHINA | 1824 | 58 |
| Chengdu Biopurify Phytochemicals Ltd. | +86-28-82633860; +8618080483897 | sales@biopurify.com | China | 3772 | 58 |
View Lastest Price from Ginsenoside Rg1 manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-04-27 | Ginsenoside Rg1
22427-39-0
|
US $990.00-800.00 / kg | 1kg | 99% | 5000 | HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD | |
 |
2025-04-27 | Ginsenoside Rg1
22427-39-0
|
US $0.00 / g | 1g | 50%-98% HPLC | 100kg | Shaanxi Cuikang Pharmaceutical Technology Co., Ltd | |
 |
2025-04-27 | Ginsenoside Rg1
22427-39-0
|
US $0.00 / g | 1g | ≥98% HPLC | 1000kg | Changsha Staherb Natural Ingredients Co., Ltd. |
-
- Ginsenoside Rg1
22427-39-0
- US $990.00-800.00 / kg
- 99%
- HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD
-
- Ginsenoside Rg1
22427-39-0
- US $0.00 / g
- 50%-98% HPLC
- Shaanxi Cuikang Pharmaceutical Technology Co., Ltd
-
- Ginsenoside Rg1
22427-39-0
- US $0.00 / g
- ≥98% HPLC
- Changsha Staherb Natural Ingredients Co., Ltd.