10,10-BIS(4-PYRIDINYLMETHYL)-9(10H)-ANTHRACENONE DIHYDROCHLORIDE
- CAS No.
- 122955-42-4
- Chemical Name:
- 10,10-BIS(4-PYRIDINYLMETHYL)-9(10H)-ANTHRACENONE DIHYDROCHLORIDE
- Synonyms
- XE 991;XE9912HCl;XE 991 DIHYDROCHLORIDE;10,10-Bis(pyridin-4-ylmethyl)anthracen-9(10H)-one;9(10H)-Anthracenone, 10,10-bis(4-pyridinylmethyl)-;10-bis(4-Pyridinylmethyl)-9(10H)-anthracenone dihydrochloride;10,10-BIS(4-PYRIDINYLMETHYL)-9(10H)-ANTHRACENONE DIHYDROCHLORIDE
- CBNumber:
- CB7349263
- Molecular Formula:
- C26H20N2O
- Molecular Weight:
- 376.45
- MDL Number:
- MFCD05662331
- MOL File:
- 122955-42-4.mol
- MSDS File:
- SDS
Melting point | 231-232 °C |
---|---|
Boiling point | 585.0±38.0 °C(Predicted) |
Density | 1.238±0.06 g/cm3(Predicted) |
storage temp. | 2-8°C |
solubility | DMSO: >20mg/mL |
form | solid |
pka | 6.08±0.10(Predicted) |
color | white to beige |
Water Solubility | Soluble in water (100mM) |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07 |
---|---|
Signal word | Warning |
Hazard statements | H315-H319-H335 |
Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 |
Hazard Codes | Xi |
Risk Statements | 36/37/38 |
Safety Statements | 26-36 |
WGK Germany | 3 |
RTECS | CB1530000 |
10,10-BIS(4-PYRIDINYLMETHYL)-9(10H)-ANTHRACENONE DIHYDROCHLORIDE price More Price(8)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | X2254 | XE-991 ≥98% (HPLC) | 122955-42-4 | 10mg | $174 | 2024-03-01 | Buy |
Sigma-Aldrich | X2254 | XE-991 ≥98% (HPLC) | 122955-42-4 | 50mg | $738 | 2024-03-01 | Buy |
Tocris | 2000 | XE991dihydrochloride ≥99%(HPLC) | 122955-42-4 | 50 | $780 | 2021-12-16 | Buy |
Tocris | 2000 | XE991dihydrochloride ≥99%(HPLC) | 122955-42-4 | 10 | $187 | 2021-12-16 | Buy |
TRC | X750953 | XE991 | 122955-42-4 | 5mg | $220 | 2021-12-16 | Buy |
10,10-BIS(4-PYRIDINYLMETHYL)-9(10H)-ANTHRACENONE DIHYDROCHLORIDE Chemical Properties,Uses,Production
Uses
XE-991 has been used as a KCNQ (Kv7.2/7.3) inhibitor to examine whether M-current inhibition affects oxytocin receptor (TGOT) mediated depolarization. It has also been used as an KCNQ inhibitor to study the ionic mechanism responsible for the overshoot/undershoot in membrane potential in mouse cholinergic interneurons (ChIs) in the presence of tetrodotoxin (TTX).
Biological Activity
Potent and selective blocker of KCNQ voltage-gated potassium channels. Blocks KCNQ2+3/M-currents (IC 50 = 0.6-0.98 μ M) and KCNQ1 homomeric channels (IC 50 = 0.75 μ M) but is less potent against KCNQ1/minK channels (IC 50 = 11.1 μ M). Augments hippocampal ACh release and is a cognitive enhancer following oral administration in vivo .
Biochem/physiol Actions
XE-991 is a KCNQ channel blocker; which is more potent than linopiridine (Cat. No. L-134).
storage
Room temperature (desiccate)
10,10-BIS(4-PYRIDINYLMETHYL)-9(10H)-ANTHRACENONE DIHYDROCHLORIDE Preparation Products And Raw materials
Raw materials
Preparation Products
10,10-BIS(4-PYRIDINYLMETHYL)-9(10H)-ANTHRACENONE DIHYDROCHLORIDE Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32836 | 60 |
HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
3B Pharmachem (Wuhan) International Co.,Ltd. | 821-50328103-801 18930552037 | 3bsc@sina.com | China | 15848 | 69 |
Ascent Scientific | 4401179829988 | customerservice@ascentscientific.co.uk | United Kingdom | 279 | 60 |
BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 14059 | 65 |
Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51471 | 80 |
Shanghai Beckham Medical Technology Co., Ltd | 021-13816613772 13816613772 | huahero21@sina.com | China | 396 | 55 |
EMMX Biotechnology LLC | 888-539-0666 | info@emmx.com | United States | 8449 | 60 |
Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9707 | 58 |