Bromonitromethane
- CAS No.
- 563-70-2
- Chemical Name:
- Bromonitromethane
- Synonyms
- 255858_ALDRICH;EINECS 209-258-0;bromonitro-methan;nitrobromomethane;BROMONITROMETHANE;Nitromethyl bromide;Methane, bromonitro-;Bromonitromethane, tech.;bromonitromethane CH2BrNO2;Bromonitromethane, 90%,tech.
- CBNumber:
- CB7381067
- Molecular Formula:
- CH2BrNO2
- Molecular Weight:
- 139.94
- MDL Number:
- MFCD00007401
- MOL File:
- 563-70-2.mol
- MSDS File:
- SDS
Melting point | -28 °C |
---|---|
Boiling point | 146-148 °C/750 mmHg (lit.) |
Density | 2.007 g/mL at 25 °C (lit.) |
refractive index | 1.485-1.495 |
Flash point | 4°C |
solubility | Chloroform (Soluble), DMSO (Sparingly), Ethyl Acetate (Slightly), Methanol (Slig |
pka | 7.22±0.29(Predicted) |
form | Liquid |
color | Clear yellow |
Stability | Light Sensitive, Volatile |
CAS DataBase Reference | 563-70-2(CAS DataBase Reference) |
EWG's Food Scores | 1 |
FDA UNII | EG63P9EUR0 |
EPA Substance Registry System | Methane, bromonitro- (563-70-2) |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS03,GHS07 |
---|---|
Signal word | Danger |
Hazard statements | H272-H315-H319-H335 |
Precautionary statements | P210-P302+P352-P305+P351+P338 |
Hazard Codes | Xn-O,Xi,O |
Risk Statements | 8-36/37/38-20/21/22 |
Safety Statements | 36/37/39-26-17-36 |
RIDADR | 3098 |
WGK Germany | 3 |
RTECS | PA5360000 |
HazardClass | 5.1 |
PackingGroup | III |
HS Code | 29049095 |
Bromonitromethane price More Price(18)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | 255858 | Bromonitromethane technical grade, 90% | 563-70-2 | 1g | $71.4 | 2024-03-01 | Buy |
Sigma-Aldrich | 255858 | Bromonitromethane technical grade, 90% | 563-70-2 | 10g | $154 | 2024-03-01 | Buy |
TRC | B686205 | Bromonitromethane | 563-70-2 | 10g | $95 | 2021-12-16 | Buy |
Biosynth Carbosynth | FB75111 | Bromonitromethane | 563-70-2 | 5G | $150 | 2021-12-16 | Buy |
Biosynth Carbosynth | FB75111 | Bromonitromethane | 563-70-2 | 25g | $400 | 2021-12-16 | Buy |
Bromonitromethane Chemical Properties,Uses,Production
Chemical Properties
Bromonitromethane is a clear yellow liquid, It is a strong oxidizing agent with properties similar to nitromethane.
Bromonitromethane has been used:
in production of various protected α-bromo nitroalkane donors (including Fmoc) for use in Umpolung amide synthesis.
in preparation of (Z)-1-bromo-1-nitroalkenes via sodium iodide-catalyzed Henry reaction.
in diastereo- and enantioselective cyclopropanation of β,γ-unsaturated a-ketoesters via domino Michael-addition/intramolecular-alkylation strategy.
Uses
Bromonitromethane has received considerable attention as a one-carbon synthon for the synthesis of a variety of important organic intermediates.
Bromonitromethane is a key starting material for the preparation of the broad-spectrum antibiotic trovafloxacin, which contains the interesting 3-azabicyclo[ 3.1.0]hexane ring system.
it was used in the synthesis of 2-nitrobenzofuran and 2-nitro-2,3-dihydrobenzofuran-3-ols, nitrobenzothio-phenes, and nitrothiazoles, polyfunctionalized nitrocyclopropanes. It has also been utilized in the synthesis of 1-bromo-1-nitroalkan-2-ols and aryl nitromethanes. In addition, it could be used as a bromine donor.
Uses
Bromonitromethane has been used:
- in production of various protected α-bromo nitroalkane donors (including Fmoc) for use in Umpolung amide synthesis
- in preparation of (Z)-1-bromo-1-nitroalkenes via sodium iodide-catalyzed Henry reaction
- in diastereo- and enantioselective cyclopropanation of β,γ-unsaturated a-ketoesters via domino Michael-addition/intramolecular-alkylation strategy
Preparation
Bromonitromethane is commercially available and can also be easily prepared according to the procedures reported by Fishwick et al. A typical procedure is as following: freshly distilled nitromethane was stirred at 0℃ and bromine was dropped in 5 seconds. The resulted bromonitromethane could be used without further purification.
Bromonitromethane Preparation Products And Raw materials
Raw materials
Preparation Products
Bromonitromethane Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
career henan chemical co | +86-0371-86658258 15093356674; | sales@coreychem.com | China | 29902 | 58 |
Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | sales@chemdad.com | China | 39916 | 58 |
CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49391 | 58 |
Richest Group Ltd | 18017061086 | oled@richest-group.com | CHINA | 5601 | 58 |
Hefei TNJ Chemical Industry Co.,Ltd. | 0551-65418671 | sales@tnjchem.com | China | 34571 | 58 |
ANHUI WITOP BIOTECH CO., LTD | +8615255079626 | eric@witopchemical.com | China | 23556 | 58 |
AFINE CHEMICALS LIMITED | +86-0571-85134551 | info@afinechem.com | China | 15395 | 58 |
Dayang Chem (Hangzhou) Co.,Ltd. | 571-88938639 +8617705817739 | info@dycnchem.com | China | 52861 | 58 |
Shaanxi Didu New Materials Co. Ltd | +86-89586680 +86-13289823923 | 1026@dideu.com | China | 9020 | 58 |
Nanjing Doge Biomedical Technology Co., Ltd | +86-25-58227606 +86-15305155328 | sales@dogechemical.com | China | 4128 | 58 |
View Lastest Price from Bromonitromethane manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2019-07-06 | BROMONITROMETHANE
563-70-2
|
US $1.00 / KG | 1KG | 99% | Customized | Career Henan Chemical Co |
- BROMONITROMETHANE
563-70-2
- US $1.00 / KG
- 99%
- Career Henan Chemical Co