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Agmatine sulfate

CAS No.
2482-00-0
Chemical Name:
Agmatine sulfate
Synonyms
AGMATINE SULPHATE;2-(4-aminobutyl)guanidine,sulfuric acid;gmatine sulfate;agmatine sulfate salt;1-AMINO-4-GUANIDINOBUTANE SULFATE SALT;ARGAMINE;matine SuL;Agmatine SuL;Agmatine sulfat;AGMATINE SULFATE
CBNumber:
CB7421831
Molecular Formula:
C5H16N4O4S
Molecular Weight:
228.27
MDL Number:
MFCD00013109
MOL File:
2482-00-0.mol
MSDS File:
SDS
Last updated:2024-11-19 23:02:33

Agmatine sulfate Properties

Melting point 234-238 °C(lit.)
RTECS ME8413000
storage temp. Keep in dark place,Inert atmosphere,Room temperature
solubility H2O: 50 mg/mL
form powder
color white to off-white
Water Solubility Soluble in water, nearly insoluble in alcohol
Merck 14,188
BRN 3918807
InChI InChI=1S/C5H14N4.H2O4S/c6-3-1-2-4-9-5(7)8;1-5(2,3)4/h1-4,6H2,(H4,7,8,9);(H2,1,2,3,4)
InChIKey PTAYFGHRDOMJGC-UHFFFAOYSA-N
SMILES C(CCCN)NC(N)=N.S(O)(O)(=O)=O
CAS DataBase Reference 2482-00-0(CAS DataBase Reference)
FDA UNII RU0176QL8I

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338
Safety Statements  22-24/25
WGK Germany  3
10
HS Code  29252900
NFPA 704
1
0 0

Agmatine sulfate price More Price(39)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich A7127 Agmatine sulfate salt ≥97%, powder 2482-00-0 1g $89 2024-03-01 Buy
TCI Chemical A0310 Agmatine Sulfate >98.0%(T) 2482-00-0 1g $48 2024-03-01 Buy
TCI Chemical A0310 Agmatine Sulfate >98.0%(T) 2482-00-0 100mg $17 2024-03-01 Buy
Alfa Aesar H55363 Agmatine sulfate, 97% 2482-00-0 1g $61.7 2024-03-01 Buy
Alfa Aesar H55363 Agmatine sulfate, 97% 2482-00-0 5g $216 2024-03-01 Buy
Product number Packaging Price Buy
A7127 1g $89 Buy
A0310 1g $48 Buy
A0310 100mg $17 Buy
H55363 1g $61.7 Buy
H55363 5g $216 Buy

Agmatine sulfate Chemical Properties,Uses,Production

General Uses

Neuroprotective, CNS studies, Autism and depression research
Description: Agmatine Sulfate is a polyamine derived from L-arginine decarboxylation and is a known putative endogenous neurotransmitter at imidazoline receptors. Agmatine sulfate displaces clonidine at α2-adrenergic and at imidazoline receptors and was recently shown to exert some neuroprotective effects. It blocks NMDA-receptor associated cation channels. Acts as a competitive inhibitor of nitric oxide synthase (NOS). It functions as neurotransmitter since it is stored in synaptic vesicles and is related from axon terminals by depolarization(1). Protects autistic behavior in rats and reverses depressive like behavior in mice.

Description

Agmatine sulfate is the sulfate of the Agmatine. Agmatine is an aninoguanidine that is naturally derived from the arginine. It can exert modulatory effect on many molecular targets such as neurotransmitter systems, opioid analgesia, ion channels, and nitric oxide (NO) synthesis and polyamine metabolism. It has been also found that it can reverse the pain induced from inflammation, neuropathy, and spinal cord injury. Those effects make it a potential candidate for multiple pharmacological applications in the future.

Chemical Properties

White to off-white powder

Uses

Agmatine is an intermediate in the biosynthesis of the polyamines putrescine and spermine. Agmatine binds with high affinity to α2-adrenergic receptors and imidazoline binding sites and produces blockade of the NMDA-receptor associated cation channels. Agmatine is a competitive inhibitor of nitric oxide synthase activity owing to mimicry of the natural NOS substrate arginine.

Uses

Agmatine Sulfate is a a polyamine derived from L-arginine (A769500) decarboxylation and is a known putative endogenous neurotransmitter at imidazoline receptors. Agmatine sulfate displaces clonidine a t α2-adrenergic and at imidazoline receptors and was recently shown to exert some neuroprotective effects.

Biological Activity

Arginine metabolite that is synthesized within bovine brain and exhibits clonidine-displacing substance (CDS) activity. Putative endogenous ligand for the imidazoline binding site.

Biochem/physiol Actions

Putative endogenous neurotransmitter at imidazoline receptors; displaces clonidine at α2-adrenergic and at imidazoline receptors; blocks NMDA-activated ion channels in hippocampal neurons.

Purification Methods

Crystallise the salt from aqueous MeOH. The free base has m 101.5-103o, the gold chloride hydrochloride crystallises from H2O with m 223o(dec), and the picrate has m 236-238o. [Odo J Chem Soc Jpn 67 132 1946, Beilstein 4 I 420, 4 II 703, 4 III 575, 4 IV 1291.]

References

Fairbanks, C. A., et al. "Agmatine reverses pain induced by inflammation, neuropathy, and spinal cord injury." Proceedings of the National Academy of Sciences of the United States of America97.19(2000):10584.
Kolesnikov, Yuri, S. Jain, and G. W. Pasternak. "Modulation of opioid analgesia by agmatine." European Journal of Pharmacology296.1(1996):17-22.
Su, R. B., J. Li, and B. Y. Qin. "A biphasic opioid function modulator: agmatine. "Acta Pharmacologica Sinica24.7(2003):631.
Galea, Elena, et al. "Inhibition of mammalian nitric oxide synthases by agmatine, an endogenous polyamine formed by decarboxylation of arginine." Biochemical Journal 316 ( Pt 1).1(1996):247.
https://en.wikipedia.org/wiki/Agmatine

Agmatine sulfate Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 487)Suppliers
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View Lastest Price from Agmatine sulfate manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Agmatine sulfate pictures 2024-12-23 Agmatine sulfate
2482-00-0
US $30.00 / kg 1kg 99% 5000kg/Month Hebei Zhuanglai Chemical Trading Co.,Ltd
Agmatine sulfate pictures 2024-12-13 Agmatine sulfate
2482-00-0
US $0.00 / Kg/Drum 1KG 99%min 500kgs WUHAN FORTUNA CHEMICAL CO., LTD
Agmatine sulfate pictures 2024-12-06 Agmatine sulfate
2482-00-0
US $0.00-0.00 / KG 1KG 99% 5000 Wuhan Haorong Biotechnology Co.,Ltd
  • Agmatine sulfate pictures
  • Agmatine sulfate
    2482-00-0
  • US $30.00 / kg
  • 99%
  • Hebei Zhuanglai Chemical Trading Co.,Ltd
  • Agmatine sulfate pictures
  • Agmatine sulfate
    2482-00-0
  • US $0.00 / Kg/Drum
  • 99%min
  • WUHAN FORTUNA CHEMICAL CO., LTD
  • Agmatine sulfate pictures
  • Agmatine sulfate
    2482-00-0
  • US $0.00-0.00 / KG
  • 99%
  • Wuhan Haorong Biotechnology Co.,Ltd
N-(4-AMINOBUTYL)GUANIDINE SULFATE N-(4-Aminobutyl)guanidine sulfate salt 1-AMINO-4-GUANIDINOBUTANE SULFATE 1-AMINO-4-GUANIDOBUTANE SULFATE 4-GUANIDINOBUTANE SULFATE 4-GUANIDINO-BUTYLAMINE SULFATE 4-GUANIDINO-BUTYLAMINE SULFATE SALT (4-AMINOBUTYL)GUANIDINE SULFATE (4-aminobutyl)guanidinium sulphate AGMATINE SULFATE ARGAMINE ARGAMINE SULFATE AGMATINESULFATE,POWDER (4-Aminobutyl)guanidinium sulfate. AGMATINE SULFATE PRACTICAL GRADE AGMATINE SULFATE((4-AMINOBUTYL)GUANIDINE) AGARICUSBLAZTIP.E 1-Amino-4-guanidinobutane sulfate salt, 4-Guanidinobutylamine sulfate salt, N-(4-Aminobutyl)guanidine sulfate salt 1-(4-aMinobutyl)guanidine sulfate Agmatine sulfate,99% Agmatine sulfate,85+% Agmatine sulfate,70% ArgaMine · sulfate, 4-Guanidino-butylaMine · sulfate AGMATINE SULFATE SALT(P) 4-Guanidinobutylamine sulphate salt guanidinobutane sulfate salt Agmatine sulfate≥ 93% (HPLC) matine SuL 4minobutyl)guanidinium sulphate Agmatine sulfate price N-(4-Aminobutyl)guanidine sulfate sal 1-Amino-4-guanidinobutane sulfate salt, 97% White to off-white powder Agmatine Sulfate > Guanidine, N-(4-aminobutyl)-, sulfate (1:1) Agmatine SuL 2-(4-aminobutyl)guanidine,sulfuricaci High Quality Factory Supply Bulk Agmatine Sulfate AGMATINE SULFATE /CAS 2482-00-0 1-(4-Aminobutyl)guanidine sulfate(Chunks or pellets) Agmatine sulftae(Fermented) 1-AMINO-4-GUANIDINOBUTANE SULFATE SALT AGMATINE SULPHATE agmatine sulfate salt 2-(4-aminobutyl)guanidine,sulfuric acid gmatine sulfate Guanidine butylamine sulfate Agmatine sulfate(Fermented) Agmatine sulfat Agmatine sulfate, 2-(4-aminobutyl)guanidine sulfuric acid Prinomastat Impurity 9 2482-00-0 2428-00-0 2482-00-1 2842-00-0 C5H16N4O4S H2NCH24NHCNHNH2H2SO4 C5H14N4H2SO4C5H16N4O4S C5H14N4H2SO4