ChemicalBook >> CAS DataBase List >>17a-Ethynyl-1,3,5(10)-estratriene-3,17b-diol 3-methyl ether
17a-Ethynyl-1,3,5(10)-estratriene-3,17b-diol 3-methyl ether
- CAS No.
- 72-33-3
- Chemical Name:
- 17a-Ethynyl-1,3,5(10)-estratriene-3,17b-diol 3-methyl ether
- Synonyms
- 33355;EE3ME;d-MVE;sc4725;RS 1044;Devocin;Norquen;Ovastol;SC 4725;MESTRANOL
- CBNumber:
- CB7426942
- Molecular Formula:
- C21H26O2
- Molecular Weight:
- 310.43
- MDL Number:
- MFCD00003689
- MOL File:
- 72-33-3.mol
Last updated:2024-12-18 14:15:30
| Melting point | 153-155 °C(lit.) |
|---|---|
| Boiling point | 390.58°C (rough estimate) |
| alpha | +2～+8°(D/20℃)(c=1, 1,4-dioxane) |
| Density | 1.0865 (rough estimate) |
| refractive index | 1.4900 (estimate) |
| storage temp. | Sealed in dry,2-8°C |
| solubility | Acetonitrile: 1 mg/ml; Ethanol: 1 mg/ml; Methanol: 1 mg/ml |
| form | Solid |
| pka | 13.10±0.40(Predicted) |
| color | White to off-white |
| optical activity | [α]15/D +3°, c = 2 in dioxane |
| Merck | 5917 |
| BRN | 2625905 |
| CAS DataBase Reference | 72-33-3(CAS DataBase Reference) |
| FDA UNII | B2V233XGE7 |
| Proposition 65 List | Mestranol |
| NIST Chemistry Reference | Mestranol(72-33-3) |
| EPA Substance Registry System | Mestranol (72-33-3) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H351 | |||||||||
| Precautionary statements | P201-P302+P352-P305+P351+P338-P308+P313 | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 36/37/38-40-48-68 | |||||||||
| Safety Statements | 22-26-36/37/39-45-36/37 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | RC8960000 | |||||||||
| HS Code | 29372900 | |||||||||
| Hazardous Substances Data | 72-33-3(Hazardous Substances Data) | |||||||||
| Toxicity | LD50 oral in rat: > 10gm/kg | |||||||||
| NFPA 704 |
|
17a-Ethynyl-1,3,5(10)-estratriene-3,17b-diol 3-methyl ether price More Price(24)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 855871 | Mestranol 99% | 72-33-3 | 500mg | $79 | 2024-03-01 | Buy |
| Sigma-Aldrich | 1394008 | Mestranol United States Pharmacopeia (USP) Reference Standard | 72-33-3 | 200mg | $164.8 | 2024-03-01 | Buy |
| Cayman Chemical | 23822 | Mestranol ≥98% | 72-33-3 | 10mg | $26 | 2024-03-01 | Buy |
| Cayman Chemical | 23822 | Mestranol ≥98% | 72-33-3 | 50mg | $98 | 2024-03-01 | Buy |
| Sigma-Aldrich | M0600000 | Mestranol European Pharmacopoeia (EP) Reference Standard | 72-33-3 | m0600000 | $60 | 2024-03-01 | Buy |
17a-Ethynyl-1,3,5(10)-estratriene-3,17b-diol 3-methyl ether Chemical Properties,Uses,Production
Chemical Properties
Crystalline Solid
Originator
Enovid ,Searle ,US ,1957
Uses
antiemetic
Uses
Pharmacological estrogen molecule
Uses
Mestranol is an orally active estrogenic steroid. It was the estrogen used in many of the first oral contraceptives
Definition
ChEBI: A terminal acetylenic compound that is (17alpha)-17-ethynylestra-1(10),2,4-triene substituted by a methoxy group at position 3 and a hydroxy group at position 17.
Manufacturing Process
A stirred solution of 120 parts of 3-methoxy-δ1,3,5-estratrien-17-one in 2,600 parts of anhydrous toluene and 4,300 parts of anhydrous ether is saturated with a slow stream of acetylene. In the course of 30 minutes there is added a solution of 120 parts of potassium tert-amylate in 2,800 parts of anhydrous tert-pentanol. The passage of acetylene and stirring are continued for an additional 5 hours after which the reaction mixture is washed 5 times with 3,000-part portions of saturated ammonium chloride solution and then with water. It is then dried over anhydrous sodium sulfate and concentrated to dryness under vacuum. The residue is recrystallized from methanol. The 3- methoxy-17-ethynyl-δ1,3,5 estratrien-17-ol thus obtained melts at about 143° to 146°C. A further recrystallization from acetone yields crystals melting at about 150° to 151°C.
Therapeutic Function
Estrogen
Safety Profile
Confirmed carcinogen with experimental. neoplastigenic, tumorigenic, and teratogenic data. Moderately toxic by subcutaneous route. Human reproductive effects by ingestion: changes in ovaries and fallopian tubes, ferthty effects. Experimental reproductive effects. Mutation data reported. An FDA proprietary drug. A steroid used in oral contraceptives. When heated to decomposition it emits acrid smoke and irritating fumes.
17a-Ethynyl-1,3,5(10)-estratriene-3,17b-diol 3-methyl ether Preparation Products And Raw materials
Global( 190)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21634 | 55 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29880 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28172 | 58 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22963 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | sales@chemdad.com | China | 39894 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49374 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32161 | 58 |
| AFINE CHEMICALS LIMITED | +86-0571-85134551 | sales@afinechem.com | China | 15352 | 58 |
| Finetech Industry Limited | +86-27-87465837 +8618971612321 | info@finetechnology-ind.com | China | 9639 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10473 | 58 |
View Lastest Price from 17a-Ethynyl-1,3,5(10)-estratriene-3,17b-diol 3-methyl ether manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-11-16 | Mestranol
72-33-3
|
US $36.00-72.00 / mg | 100% | 10g | TargetMol Chemicals Inc. | ||
 |
2023-09-14 | mestranol
72-33-3
|
US $0.00-0.00 / KG | 1KG | 99% | 50TONS | Wuhan Han Sheng New Material Technology Co.，Ltd | |
 |
2022-12-29 | mestranol
72-33-3
|
US $1.00 / g | 10g | 99.5% | 1000kg | Guangzhou Biocar Biotechnology Co.,Ltd. |
17a-Ethynyl-1,3,5(10)-estratriene-3,17b-diol 3-methyl ether Spectrum
17a-Ethynyl-1,3,5(10)-estratriene-3,17b-diol 3-methyl ether(72-33-3)MS17a-Ethynyl-1,3,5(10)-estratriene-3,17b-diol 3-methyl ether(72-33-3)1HNMR17a-Ethynyl-1,3,5(10)-estratriene-3,17b-diol 3-methyl ether(72-33-3)13CNMR17a-Ethynyl-1,3,5(10)-estratriene-3,17b-diol 3-methyl ether(72-33-3)IR117a-Ethynyl-1,3,5(10)-estratriene-3,17b-diol 3-methyl ether(72-33-3)IR217a-Ethynyl-1,3,5(10)-estratriene-3,17b-diol 3-methyl ether(72-33-3)Raman
72-33-3(17a-Ethynyl-1,3,5(10)-estratriene-3,17b-diol 3-methyl ether)Related Search:
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8027 C. B.
component of Norinyl
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Compound 33355
compound33355
delta-MVE
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ETHYNYLESTRADIOL 3-METHYL ETHER
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(8R,9S,13S,14S,17R)-17-ETHYNYL-3-METHOXY-13-METHYL-7,8,9,11,12,13,14,15,16,17-DECAHYDRO-6H-CYCLOPENTA[A]PHENANTHREN-17-OL
17a-ethynyl-1,3,5(10)-estratriene-3,17b-diol 3-methyl ether
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17-ALPHA-ETHINYL-OESTRADIOL-3-METHYL ETHER
17ALPHA-ETHYNYL-1,3,5(10)-ESTRATRIENE-3,17BETA-DIOL 3-METHYL ETHER
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17a-Ethynyl-3-methoxy-17b-hydroxy-1,3,5(10)-estratriene
3-Methoxy-17a-ethynylestradiol
(17a)-3-Methoxy-19-norpregna-1,3,5(10)-trien-20-yn-17-ol
Menophase
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