BIS(7)-TACRINE
- CAS No.
- 224445-12-9
- Chemical Name:
- BIS(7)-TACRINE
- Synonyms
- BIS(7)-TACRINE;Bis(heptyl)-cognitin dihydrochloride;Bis(heptyl)-cognitin dihydrochloride >=98% (HPLC);N,N'-BIS(1,2,3,4-TETRAHYDRO-9-ACRIDINYL)-1,7-HEPTANEDIAMINE, DIHYDROCHLORIDE;heptylene-bis(tacrine) dihydrochloride, heptylene-bis(THA) dihydrochloride
- CBNumber:
- CB7428931
- Molecular Formula:
- C33H42Cl2N4
- Molecular Weight:
- 565.62
- MDL Number:
- MFCD08062163
- MOL File:
- 224445-12-9.mol
SAFETY
Risk and Safety Statements
| Hazard Codes | T |
|---|---|
| Risk Statements | 25-36/37/38 |
| Safety Statements | 26-36-45 |
| RIDADR | UN 2811 6.1/PG 3 |
BIS(7)-TACRINE price More Price(9)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML1598 | Bis(heptyl)-cognitin dihydrochloride ≥98% (HPLC) | 224445-12-9 | 5mg | $71.6 | 2022-05-15 | Buy |
| Sigma-Aldrich | SML1598 | Bis(heptyl)-cognitin dihydrochloride ≥98% (HPLC) | 224445-12-9 | 25mg | $291 | 2022-05-15 | Buy |
| Cayman Chemical | 10005836 | bis(7)-Tacrine ≥98% | 224445-12-9 | 5mg | $79 | 2024-03-01 | Buy |
| Cayman Chemical | 10005836 | bis(7)-Tacrine ≥98% | 224445-12-9 | 10mg | $150 | 2024-03-01 | Buy |
| Cayman Chemical | 10005836 | bis(7)-Tacrine ≥98% | 224445-12-9 | 50mg | $623 | 2024-03-01 | Buy |
BIS(7)-TACRINE Chemical Properties,Uses,Production
Biological Activity
bis(7)-tacrine is an ache inhibitor.acetylcholinesterase ( ache), the primary cholinesterase in the body, is an enzyme catalyzing the breakdown of acetylcholine and of some other choline esters that function as neurotransmitters.
in vitro
bis(7)-tacrine, the 9-amino-1,2,3,4-tetrahydroacridine (tha) dimer, was identified as a promising drug candidate for the palliative treatment of alzheimer's disease, due to its significant enhancement in acetylcholinesterase (ache) inhibition potency and ache/butyrylcholinesterase (bche) selectivity relative to tha itself. enzyme kinetic studies performed in rat cortex found that both bis(7)-tacrine and tha exhibited mixed inhibition, and the rat cortex ki values were consistent with the previously determined human cerebellum ki values [1].
in vivo
previous study evaluated the neuropharmacological effects of tha on memory impairment caused by scopolamine injection. balb/c mice were orally treated with tha at 10 mg/kg for 10 days. results showed that tha significantly could reduce the total number of entry error and reference memory errors. in addition, tha also inhibited the ache activity in the hippocampus significantly [2].
IC 50
0.40 nm
References
[1] carlier, p. r.,han, y.f.,chow, e.s.h., et al. evaluation of short-tether bis-tha ache inhibitors. a further test of the dual binding site hypothesis. bioorganic & medicinal chemistry 7, 351-357 (1999).
[2] lee js, hong ss, kim hg, lee hw, kim wy, lee sk, son cg. gongjin-dan enhances hippocampal memory in a mouse model of scopolamine-induced amnesia. plos one. 2016 aug 2;11(8):e0159823.
BIS(7)-TACRINE Preparation Products And Raw materials
Raw materials
Preparation Products
BIS(7)-TACRINE Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11289 | 58 |
| MedBioPharmaceutical Technology Inc | 021-69568360 18916172912 | order@med-bio.cn | China | 8141 | 58 |
| Energy Chemical | 021-58432009 400-005-6266 | marketing@energy-chemical.com | China | 44941 | 58 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24017 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 8740 | 58 |
| ApexBio Technology | -- | sales@apexbt.com | United States | 6254 | 58 |