N-Ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline
- CAS No.
- 16357-59-8
- Chemical Name:
- N-Ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline
- Synonyms
- EEDQ;2-ETHOXY-1-ETHOXYCARBONYL-1,2-DIHYDROQUINOLINE;ethyl 2-ethoxyquinoline-1(2H)-carboxylate;ethyl 2-ethoxy-1,2-dihydroquinoline-1-carboxylate;2-Ethoxy-2H-quinoline-1-carboxylic acid ethyl ester;EEDQ extrapure;2-Ethoxy-1-ethoxycar;LABOTEST-BB LT00440890;EEDQ (1-ETHOXY-CARBONYL-2-ETHOXY-1,2;ETHYL 2-ETHOXY-1,2-DIHYDRO-1-QUINOLINECA
- CBNumber:
- CB7436031
- Molecular Formula:
- C14H17NO3
- Molecular Weight:
- 247.29
- MDL Number:
- MFCD00006703
- MOL File:
- 16357-59-8.mol
- MSDS File:
- SDS
Melting point | 62-67 °C(lit.) |
---|---|
Boiling point | 125-128 °C (0.1 mmHg) |
Density | 1.1173 (rough estimate) |
refractive index | 1.5300 (estimate) |
Flash point | 125-128°C/0.1mm |
storage temp. | 2-8°C |
solubility | Chlorofrom (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly) |
pka | -1.27±0.40(Predicted) |
form | Crystalline Powder |
color | White to beige |
Water Solubility | insoluble |
Sensitive | Moisture Sensitive |
Merck | 14,3518 |
BRN | 533048 |
CAS DataBase Reference | 16357-59-8(CAS DataBase Reference) |
EWG's Food Scores | 1 |
FDA UNII | 60O971AN19 |
EPA Substance Registry System | 1(2H)-Quinolinecarboxylic acid, 2-ethoxy-, ethyl ester (16357-59-8) |
SAFETY
Risk and Safety Statements
Symbol(GHS) | ![]() GHS07 |
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Signal word | Warning | |||||||||
Hazard statements | H302-H315-H319-H335 | |||||||||
Precautionary statements | P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313-P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
Hazard Codes | Xi,Xn | |||||||||
Risk Statements | 38-36/37/38-20/21/22 | |||||||||
Safety Statements | 22-24/25-36/37/39-26-36 | |||||||||
WGK Germany | 3 | |||||||||
RTECS | VB2010000 | |||||||||
F | 9-21 | |||||||||
TSCA | Yes | |||||||||
HS Code | 29334990 | |||||||||
Toxicity | mouse,LD50,intraperitoneal,32mg/kg (32mg/kg),Journal of Medicinal Chemistry. Vol. 14, Pg. 49, 1971. | |||||||||
NFPA 704 |
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N-Ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline price More Price(44)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | 149837 | 2-Ethoxy-1-ethoxycarbonyl-1,2-dihydroquinoline ≥99% | 16357-59-8 | 5g | $21.84 | 2024-03-01 | Buy |
Sigma-Aldrich | 149837 | 2-Ethoxy-1-ethoxycarbonyl-1,2-dihydroquinoline ≥99% | 16357-59-8 | 25g | $70.6 | 2024-03-01 | Buy |
TCI Chemical | E0363 | 1-Ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline >98.0%(HPLC)(T) | 16357-59-8 | 25g | $29 | 2024-03-01 | Buy |
Alfa Aesar | A13724 | 2-Ethoxy-1-ethoxycarbonyl-1,2-dihydroquinoline, 99% | 16357-59-8 | 10g | $32.2 | 2024-03-01 | Buy |
Alfa Aesar | A13724 | 2-Ethoxy-1-ethoxycarbonyl-1,2-dihydroquinoline, 99% | 16357-59-8 | 50g | $90.65 | 2024-03-01 | Buy |
N-Ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline Chemical Properties,Uses,Production
Chemical Properties
White to pale yellow solid
Uses
2-Ethoxy-1-ethoxycarbonyl-1,2-dihydroquinoline is an irreversible membrane-bound receptor antagonist. It is used in synthetic chemistry, discovery, process R&D. It also acts as coupling reagents.
Uses
In the synthesis of peptides.
Uses
Peptide condensing agent with little or no racemization. Amidation coupling reagent.
Purification Methods
Dissolve EEDQ ~180g in CHCl3, evaporate to dryness in a vacuum. Add dry Et2O (20mL) and a white solid separates on standing. Set aside for a few hours, collect the solid, wash it thoroughly with cold Et2O and dry it in a vacuum (~140g, m 63.5-65o). A further crop of solid (~25g) is obtained from the filtrate on standing overnight. [Fieser & Fieser Reagents for Organic Synthesis 2 191 1969, Belleau et al. J Am Chem Soc 90 823 1968 and 90 1651 1968, Beilstein 21/3 V 28.]
![91-22-5](/CAS/GIF/91-22-5.gif)
![64-17-5](/CAS/GIF/64-17-5.gif)
![541-41-3](/CAS/GIF/541-41-3.gif)
![16357-59-8](/CAS/GIF/16357-59-8.gif)
N-Ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Watson Biotechnology Co.,Ltd | +86-18186686046 +86-18186686046 | sales01@watsonbiotech.cn | China | 5853 | 58 |
Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29798 | 60 |
Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | info@dakenam.com | China | 16911 | 58 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21668 | 55 |
AB PharmaTech,LLC | 323-480-4688 | United States | 989 | 55 | |
Shanghai Zheyan Biotech Co., Ltd. | 18017610038 | zheyansh@163.com | CHINA | 3620 | 58 |
career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29892 | 58 |
SHANDONG ZHI SHANG CHEMICAL CO.LTD | +86 18953170293 | sales@sdzschem.com | China | 2931 | 58 |
Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | admin@nexconn.com | China | 10312 | 58 |
Jinan Carbotang Biotech Co.,Ltd. | +8615866703830 | figo.gao@foxmail.com | China | 7621 | 58 |
View Lastest Price from N-Ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
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2024-08-30 | N-Ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline
16357-59-8
|
US $0.00-0.00 / kg | 1kg | 99% | 1000kg | WUHAN FORTUNA CHEMICAL CO., LTD | |
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2024-08-30 | EEDQ 2-Ethoxy-1-ethoxycarbonyl-1,2-dihydroquinoline
16357-59-8
|
US $0.00-0.00 / kg | 1kg | 99% | 20MT | Watson Biotechnology Co.,Ltd | |
![]() |
2022-09-27 | N-Ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline
16357-59-8
|
US $0.00-0.00 / KG | 1KG | 98% | 1ton | Henan Aochuang Chemical Co.,Ltd. |
-
- N-Ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline
16357-59-8
- US $0.00-0.00 / kg
- 99%
- WUHAN FORTUNA CHEMICAL CO., LTD
-
- EEDQ 2-Ethoxy-1-ethoxycarbonyl-1,2-dihydroquinoline
16357-59-8
- US $0.00-0.00 / kg
- 99%
- Watson Biotechnology Co.,Ltd
-
- N-Ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline
16357-59-8
- US $0.00-0.00 / KG
- 98%
- Henan Aochuang Chemical Co.,Ltd.