ChemicalBook >> CAS DataBase List >>4,5-DIHYDRO-N-[4-[[4-(1-METHYLETHOXY)PHENYL]METHYL]PHENYL]-1H-IMIDAZOL-2-AMINE

4,5-DIHYDRO-N-[4-[[4-(1-METHYLETHOXY)PHENYL]METHYL]PHENYL]-1H-IMIDAZOL-2-AMINE

4,5-DIHYDRO-N-[4-[[4-(1-METHYLETHOXY)PHENYL]METHYL]PHENYL]-1H-IMIDAZOL-2-AMINE structure

CAS No.: 221529-58-4

Chemical Name:: 4,5-DIHYDRO-N-[4-[[4-(1-METHYLETHOXY)PHENYL]METHYL]PHENYL]-1H-IMIDAZOL-2-AMINE

Synonyms: CAY10441;RO1138452;CAY10441 RO1138452;RO1138452 CAY10441;CAY10441 Exclusive;RO1138452, 10 mM in DMSO;RO 1138452;RO-1138452;RO1138452;CAY 10441;CAY-10441;CAY10441;N-(4-(4-Isopropoxybenzyl)phenyl)-4,5-dihydro-1H-imidazol-2-amine;4,5-DIHYDRO-N-[4-[[4-(1-METHYLETHOXY)PHENYL]METHYL]PHENYL]-1H-IMIDAZOL-2-AMINE;1H-Imidazol-2-amine, 4,5-dihydro-N-[4-[[4-(1-methylethoxy)phenyl]methyl]phenyl]-

CBNumber:: CB7455737

Molecular Formula:: C19H23N3O

Molecular Weight:: 309.41

MDL Number:: MFCD08062147

MOL File:: 221529-58-4.mol

MSDS File:: SDS

Last updated:2025-04-29 09:03:59

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4,5-DIHYDRO-N-[4-[[4-(1-METHYLETHOXY)PHENYL]METHYL]PHENYL]-1H-IMIDAZOL-2-AMINE Properties

Boiling point	449.7±47.0 °C(Predicted)
Density	1.13±0.1 g/cm3(Predicted)
storage temp.	under inert gas (nitrogen or Argon) at 2–8 °C
solubility	DMF: 30 mg/ml; DMF:PBS (pH 7.2)(1:10): 0.05 mg/ml; DMSO: 20 mg/ml; Ethanol: 20 mg/ml
form	A crystalline solid
pka	9.94±0.33(Predicted)
color	Light yellow to brown
FDA UNII	DH5W8F3S4H

4,5-DIHYDRO-N-[4-[[4-(1-METHYLETHOXY)PHENYL]METHYL]PHENYL]-1H-IMIDAZOL-2-AMINE price More Price(24)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Cayman Chemical	10005186	CAY10441 ≥98%	221529-58-4	5mg	$150	2024-03-01	Buy
Cayman Chemical	10005186	CAY10441 ≥98%	221529-58-4	10mg	$230	2024-03-01	Buy
Cayman Chemical	10005186	CAY10441 ≥98%	221529-58-4	25mg	$558	2024-03-01	Buy
Cayman Chemical	10005186	CAY10441 ≥98%	221529-58-4	50mg	$916	2024-03-01	Buy
ChemScene	CS-0031508	RO1138452 98.21%	221529-58-4	100mg	$1250	2021-12-16	Buy

Product number	Packaging	Price	Buy
10005186	5mg	$150	Buy
10005186	10mg	$230	Buy
10005186	25mg	$558	Buy
10005186	50mg	$916	Buy
CS-0031508	100mg	$1250	Buy

4,5-DIHYDRO-N-[4-[[4-(1-METHYLETHOXY)PHENYL]METHYL]PHENYL]-1H-IMIDAZOL-2-AMINE Chemical Properties,Uses,Production

Uses

RO1138452 is a potent and selective IP (prostacyclin) receptor antagonist. RO1138452 displays high affinity for IP receptors. In human platelets, pKi is 9.3±0.1; in a recombinant IP receptor system, pKi is 8.7±0.06.

in vivo

RO1138452 is a potent and selective antagonist for both human and rat IP receptors and that is possesses analgesic and anti-inflammatory potential. RO1138452 (1-10 mg/kg, i.v.) significantly reduces acetic acid-induced abdominal constrictions. RO1138452 (3-100 mg/kg, p.o.) significantly reduces carrageenan-induced mechanical hyperalgesia and edema formation. One hour after administration of RO1138452 (5 mg/kg, i.v.) to rats, the total plasma concentration is 0.189 μg/mL, whereas the free plasma concentrations is calculated to be 0.009 μg/mL (28 nM)^[1].

IC 50

Rat I₂ Receptor: 7 nM (IC₅₀); Rat I₂ Receptor: 8.33 (pKi); Rabbit PAF Receptor: 52.9 nM (IC₅₀); Human α_2A adrenoceptor: 724 nM (IC₅₀); Rat α_1B adrenoceptor: 3280 nM (IC₅₀); Human Muscarinic M₄ Receptor: 1450 nM (IC₅₀); Human muscarinic M₂ Receptor: 2220 nM (IC₅₀); Human muscarinic M₁ Receptor: 2570 nM (IC₅₀); Human muscarinic M₅ Receptor: 3110 nM (IC₅₀); Rat 5-HT_1B Receptor: 1130 nM (IC₅₀); pig 5-HT_2C Receptor: 1190 nM (IC₅₀); Rat 5-HT_2A Receptor: 3040 nM (IC₅₀); Human 5-HT_1A Receptor: 8580 nM (IC₅₀); Guinea-pig 5-HT₄ Receptor: 8910 nM (IC₅₀); Rat α_1B adrenoceptor: 5.87 (pKi); Human α_2A adrenoceptor: 6.49 (pKi); Human muscarinic M₁ Receptor: 5.66 (pKi); Human muscarinic M₅ Receptor: 5.81 (pKi); Human muscarinic M₂ Receptor: 5.88 (pKi); Human muscarinic M₄ Receptor: 6.14 (pKi); Rabbit PAF Receptor: 7.9 (pKi); Guinea-pig 5-HT₄ Receptor: 5.35 (pKi); Human 5-HT_1A Receptor: 5.37 (pKi); Rat 5-HT_2A Receptor: 5.71 (pKi); Rat 5-HT_1B Receptor: 6.11 (pKi); Pig 5-HT_2C Receptor: 6.11 (pKi)

References

[1] Bley KR, et al. RO1138452 and RO3244794: characterization of structurally distinct, potent and selective IP (prostacyclin) receptor antagonists. Br J Pharmacol. 2006 Feb;147(3):335-45. DOI:10.1038/sj.bjp.0706554
[2] Ayer LM, et al. 4,5-Dihydro-1H-imidazol-2-yl)-[4-(4-isopropoxy-benzyl)-phenyl]-amine (RO1138452) is a selective, pseudo-irreversible orthosteric antagonist at the prostacyclin (IP)-receptor expressed by human airway epithelial cells: IP-receptor-mediated inhibition of CXCL9 and CXCL10 release. J Pharmacol Exp Ther. 2008 Feb;324(2):815-26. DOI:10.1124/jpet.107.129312

4,5-DIHYDRO-N-[4-[[4-(1-METHYLETHOXY)PHENYL]METHYL]PHENYL]-1H-IMIDAZOL-2-AMINE Preparation Products And Raw materials

Raw materials

Preparation Products

4,5-DIHYDRO-N-[4-[[4-(1-METHYLETHOXY)PHENYL]METHYL]PHENYL]-1H-IMIDAZOL-2-AMINE Suppliers

Global( 60)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19552	58
career henan chemical co	+86-0371-86658258 +8613203830695	factory@coreychem.com	China	29808	58
SHANGHAI T&W PHARMACEUTICAL CO., LTD.	+86-021-61551413 +8618813727289	contact@trustwe.com	China	5738	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	32239	58
Alfa Chemistry		Info@alfa-chemistry.com	United States	24072	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6391	58
TargetMol Chemicals Inc.		support@targetmol.com	United States	38648	58
Aladdin Scientific		tp@aladdinsci.com	United States	57505	58
Amadis Chemical Company Limited	571-89925085	sales@amadischem.com	China	131957	58

Supplier	Advantage
ATK CHEMICAL COMPANY LIMITED	60
BOC Sciences	58
career henan chemical co	58
SHANGHAI T&W PHARMACEUTICAL CO., LTD.	58
TargetMol Chemicals Inc.	58
Alfa Chemistry	58
InvivoChem	58
TargetMol Chemicals Inc.	58
Aladdin Scientific	58
Amadis Chemical Company Limited	58

View Lastest Price from 4,5-DIHYDRO-N-[4-[[4-(1-METHYLETHOXY)PHENYL]METHYL]PHENYL]-1H-IMIDAZOL-2-AMINE manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2025-04-29	RO1138452 221529-58-4	US $44.00-97.00 / mg		99.34%	10g	TargetMol Chemicals Inc.
	2019-12-26	4,5-DIHYDRO-N-[4-[[4-(1-METHYLETHOXY)PHENYL]METHYL]PHENYL]-1H-IMIDAZOL-2-AMINE 221529-58-4	US $1.00 / g	1g	99%	200kg	Career Henan Chemical Co

RO1138452
221529-58-4
US $44.00-97.00 / mg
99.34%
TargetMol Chemicals Inc.

4,5-DIHYDRO-N-[4-[[4-(1-METHYLETHOXY)PHENYL]METHYL]PHENYL]-1H-IMIDAZOL-2-AMINE
221529-58-4
US $1.00 / g
99%
Career Henan Chemical Co

221529-58-4(4,5-DIHYDRO-N-[4-[[4-(1-METHYLETHOXY)PHENYL]METHYL]PHENYL]-1H-IMIDAZOL-2-AMINE)Related Search:

4,5-DIHYDRO-N-[4-[[4-(1-METHYLETHOXY)PHENYL]CARBONYL]PHENYL]-1H-IMIDAZOL-2-AMINE 4,5-DIHYDRO-N-[4-[[4-(1-METHYLETHOXY)PHENYL]METHYL]PHENYL]-1H-IMIDAZOL-2-AMINE

4,5-DIHYDRO-N-[4-[[4-(1-METHYLETHOXY)PHENYL]METHYL]PHENYL]-1H-IMIDAZOL-2-AMINE RO1138452 CAY10441 Exclusive N-(4-(4-Isopropoxybenzyl)phenyl)-4,5-dihydro-1H-imidazol-2-amine CAY10441 CAY10441 RO1138452 RO1138452 CAY10441 RO 1138452;RO-1138452;RO1138452;CAY 10441;CAY-10441;CAY10441 1H-Imidazol-2-amine, 4,5-dihydro-N-[4-[[4-(1-methylethoxy)phenyl]methyl]phenyl]- RO-1138452,Inhibitor,RO1138452,CAY 10441,inhibit,CAY-10441,Prostaglandin Receptor,RO 1138452 RO1138452, 10 mM in DMSO 221529-58-4 API