Odevixibat
- CAS No.
- 501692-44-0
- Chemical Name:
- Odevixibat
- Synonyms
- AZD 8294;AR-H064974;AR-H-064974;AR-H 064974;Odevixibat);A4250 (A-4250;Unii-2W150K0uuc;Odevixibat(A4250);(S)-2-((R)-2-(2-((3,3-Dibutyl-7-(methylthio)-1,1-dioxido-5-phenyl-2,3,4,5-tetrahydrobenzo[f][1,2,5]thiadiazepin-8-yl)oxy)acetamido)-2-(4-hydroxyphenyl)acetamido)butanoic acid;(2S)-2-[(2R)-2-(2-{[3,3-dibutyl-7-(methylsulfanyl)-1,1-dioxo-5-phenyl-2,3,4,5-tetrahydro-1λ?,2,5-benzothiadiazepin-8-yl]oxy}acetamido)-2-(4-hydroxyphenyl)acetamido]butanoic acid
- CBNumber:
- CB74844425
- Molecular Formula:
- C37H48N4O8S2
- Molecular Weight:
- 740.93
- MDL Number:
- MFCD32710220
- MOL File:
- 501692-44-0.mol
| Density | 1.34±0.1 g/cm3(Predicted) |
|---|---|
| storage temp. | Store at -20°C, stored under nitrogen |
| solubility | DMSO : 166.67 mg/mL (224.95 mM; Need ultrasonic) |
| form | A solid |
| pka | 3.32±0.10(Predicted) |
| color | White to off-white |
| FDA UNII | 2W150K0UUC |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
Odevixibat Chemical Properties,Uses,Production
Uses
Odevixibat (A4250) is a selective and orally active ileal apical sodium-dependent bile acid transporter (ASBT) inhibitor. Odevixibat decreases cholestatic liver and bile duct injury in mice model. Odevixibat has the potential for the treatment of primary biliary cirrhosis[1].
Biological Activity
Odevixib at is an orally active, potent and selective ileal bile acid transporter (IBAT; ASBT; SLC10A2) inhibitor th at improves cholestatic liver and bile duct injury in a mouse model of sclerosing cholangitis (0.01% w/w in diet).
in vivo
Odevixibat (A4250)(0.01% (w/w) in chow diet; 4 weeks) improves sclerosing cholangitis and significantly reduces serum alanine aminotransferase, alkaline phosphatase and BAs levels, hepatic expression of pro-inflammatory and pro-fibrogenic genes and bile duct proliferation in Mdr2-/- mice[1]. In addition, Odevixibat (A4250) significantly reduces bile flow and biliary BA output, which correlates with reduced bsep transcription, while Ntcp and Cyp7a1 are induced[1].
| Animal Model: | Eight week old Mdr2-/- (Abcb4-/-) mice (model of cholestatic liver injury and sclerosing cholangitis)[1] |
| Dosage: | 0.01% (w/w) in chow diet |
| Administration: | 4 weeks |
| Result: | Decreased cholestatic liver and bile duct injury in mice model. |
References
[1] Baghdasaryan A, et al. Inhibition of intestinal bile acid absorption improves cholestatic liver and bile duct injury in a mouse model of sclerosing cholangitis.J Hepatol. 2016 Mar;64(3):674-81. DOI:10.1016/j.jhep.2015.10.024
Odevixibat Preparation Products And Raw materials
Raw materials
Preparation Products
Odevixibat Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21628 | 55 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32159 | 58 |
| Wuhan Demeikai Biotechnology Co., Ltd | +8618942921723 | info@dmksw.xin | China | 717 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8467 | 58 |
| LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43340 | 58 |
| Wuhan Circle Star Chem-medical Technology Co.,Ltd | 027-85558552 +undefined13437180835 | Janel@circlestar-chem.com | China | 1000 | 58 |
| Guangzhou Biocar Biotechnology Co.,Ltd. | +86-13397196830 | carrie@gzbiocar.cn | China | 435 | 58 |
| Suzhou Haoyi Biotechnology Technology Co., Ltd. | 15995756885 | 15995756885@139.com | China | 45 | 58 |
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- Jan 16，2024
View Lastest Price from Odevixibat manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-04-21 | Odevixibat
501692-44-0
|
US $0.00-0.00 / g | 1g | 98 | 1000 | Wuhan Circle Star Chem-medical Technology Co.,Ltd |
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- Odevixibat
501692-44-0
- US $0.00-0.00 / g
- 98
- Wuhan Circle Star Chem-medical Technology Co.,Ltd