GO 289)
- CAS No.
- 694522-87-7
- Chemical Name:
- GO 289)
- Synonyms
- GO 289);(E/Z） O289;(EZ)-GO289;GO289 (GO-289;(E/Z)-GO289, 10 mM in DMSO;5-Bromo-2-methoxy-4-(((3-(methylthio)-5-phenyl-4H-1,2,4-triazol-4-yl)imino)methyl)phenol;Phenol, 5-bromo-2-methoxy-4-[[[3-(methylthio)-5-phenyl-4H-1,2,4-triazol-4-yl]imino]methyl]-;Inhibitor,cancer,(E/Z)GO289,circadian,(E/Z)-GO-289,cell,clock,rhythms,growth,(E/Z) GO289,phosphorylation,(E/Z)-GO289,Casein Kinase,inhibit
- CBNumber:
- CB74844814
- Molecular Formula:
- C17H15BrN4O2S
- Molecular Weight:
- 419.3
- MDL Number:
- MFCD03718152
- MOL File:
- 694522-87-7.mol
GO 289) price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML3447 | GO289 ≥98% (HPLC) | 694522-87-7 | 5MG | $132 | 2024-03-01 | Buy |
| Sigma-Aldrich | SML3447 | GO289 ≥98% (HPLC) | 694522-87-7 | 25MG | $426 | 2024-03-01 | Buy |
| TRC | G767505 | GO289 | 694522-87-7 | 50mg | $765 | 2021-12-16 | Buy |
| TRC | G767505 | GO289 | 694522-87-7 | 100mg | $1320 | 2021-12-16 | Buy |
| TRC | G767505 | GO289 | 694522-87-7 | 10mg | $165 | 2021-12-16 | Buy |
GO 289) Chemical Properties,Uses,Production
Uses
GO289, is a new potent and highly selective CK2 inhibitor, which strongly lengthens circadian period. It inhibits multiple phsphorylation sites on clock proteins, including PER2 S693. GO289, also exhibited cell type-dependent inhibition of cancer cell growth that correlated with cellular clock function.
Biological Activity
GO289 is a highly potent and selective casein kinase CK2 (CKII) inhibitor (IC50 = 7 nM/CK2, 13 μM/PIM2, >50 μM/CLK2; <50% inhibition of CK1α/δ/γ and 56 other kinases at 5 μM) th at targets CK2-specific residues (CK2α V66, M163, and H160) with more overall interactions at the CK2 ATP-binding pocket than TBB, DM at & CX-4945. GO289 selectively inhibits cellular CK1 substrates phosphorylation (0.8-8 μM; HEK293T, U2OS), including clock proteins PER2, CRY1, CLOCK & BMAL1, and displays circadian period-lengthening (Bmal1-dLuc USOS EC50 = 3.3 μM) as well as growth inhibitory potency in CK2-dependent human renal cell carcinoma (RCC) cultures.
GO 289) Preparation Products And Raw materials
Raw materials
Preparation Products
GO 289) Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32159 | 58 |
| TargetMol Chemicals Inc. | support@targetmol.com | United States | 38630 | 58 | |
| Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd | +86-18341751992 +86-15382112998 | 757984502@qq.com | China | 892 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 57505 | 58 | |
| Shanghai Sphchem Co., Ltd. | 021-56491756 13512199871 | 2819742715@qq.com | China | 4000 | 55 |
| BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 12952 | 65 |
| ShangHai Caerulum Pharma Discovery Co., Ltd. | 18149758185 18149758185 | sales-cpd@caerulumpharma.com | China | 3466 | 58 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4601 | 55 | |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9803 | 58 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 021-61312847; 18021002903 | 3008007409@qq.com | China | 71829 | 60 |
View Lastest Price from GO 289) manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-11-19 | (E/Z)-GO289
694522-87-7
|
US $31.00-119.00 / mg | 98.10% | 10g | TargetMol Chemicals Inc. |
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- (E/Z)-GO289
694522-87-7
- US $31.00-119.00 / mg
- 98.10%
- TargetMol Chemicals Inc.