INDOMETHACIN N-OCTYL AMIDE
- CAS No.
- 282728-65-8
- Chemical Name:
- INDOMETHACIN N-OCTYL AMIDE
- Synonyms
- INDOMETHACIN N-OCTYL AMIDE;N-OCTYL-1-(4-CHLOROBENZOYL)-5-METHOXY-1H-INDOLE-3-ACETAMIDE;2-[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]-N-octylacetamide;1H-Indole-3-acetamide, 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-N-octyl-
- CBNumber:
- CB7490411
- Molecular Formula:
- C27H33ClN2O3
- Molecular Weight:
- 469.02
- MDL Number:
- MFCD03412026
- MOL File:
- Mol file
INDOMETHACIN N-OCTYL AMIDE price More Price(8)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 70273 | Indomethacin N-octyl amide ≥98% | 282728-65-8 | 1mg | $25 | 2024-03-01 | Buy |
| Cayman Chemical | 70273 | Indomethacin N-octyl amide ≥98% | 282728-65-8 | 5mg | $107 | 2024-03-01 | Buy |
| Cayman Chemical | 70273 | Indomethacin N-octyl amide ≥98% | 282728-65-8 | 10mg | $186 | 2024-03-01 | Buy |
| Cayman Chemical | 70273 | Indomethacin N-octyl amide ≥98% | 282728-65-8 | 50mg | $807 | 2024-03-01 | Buy |
| ApexBio Technology | C5591 | IndomethacinN-octylamide | 282728-65-8 | 50mg | $922 | 2021-12-16 | Buy |
INDOMETHACIN N-OCTYL AMIDE Chemical Properties,Uses,Production
Biological Activity
indomethacin n-octyl amide is a potent and non-selective inhibitor of both cox-1 and cox-2 [1].cyclooxygenase (cox) is the key enzyme required for the conversion of arachidonic acid to prostaglandins. cyclooxygenase enzymes have been involved in diverse physiological situations and disease processes ranging from inflammation to cancer. until now, two cyclooxygenase isoforms have been identified, cox-1 and cox-2. the cox-1 enzyme is produced constitutively (i.e., gastric mucosa) and cox-2 is inducible (i.e., sites of inflammation) [2].indomethacin is a potent but non-selective inhibitor of both cox-1 and cox-2. indomethacin is a substituted indole acetic acid, wherein the carboxylate can be derivitized as an ester or amide. conversion of indomethacin into ester and amide derivatives provides a facile strategy for generating highly selective cox-2 inhibitors. indomethacin n-octyl amide inhibited the activity of ovine cox-1 and human recombinant cox-2 with the ic50 values of 66 μm and 40 nm, respectively. while the ic50 of indomethacin for the inhibition of cox-1 and cox-2 were 0.67 μm and 0.05 μm, respectively [1].
References
[1] kalgutkar a s, marnett a b, crews b c, et al. ester and amide derivatives of the nonsteroidal antiinflammatory drug, indomethacin, as selective cyclooxygenase-2 inhibitors[j]. journal of medicinal chemistry, 2000, 43(15): 2860-2870.
[2] dubois r n, abramson s b, crofford l, et al. cyclooxygenase in biology and disease[j]. the faseb journal, 1998, 12(12): 1063-1073.
INDOMETHACIN N-OCTYL AMIDE Preparation Products And Raw materials
Raw materials
Preparation Products
INDOMETHACIN N-OCTYL AMIDE Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 14059 | 65 |
| MedBioPharmaceutical Technology Inc | 021-69568360 18916172912 | order@med-bio.cn | China | 8141 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 8739 | 58 |
| ApexBio Technology | -- | sales@apexbt.com | United States | 6254 | 58 |
| Supplier | Advantage |
|---|---|
| BOC Sciences | 65 |
| MedBioPharmaceutical Technology Inc | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 58 |
| ApexBio Technology | 58 |