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INDOMETHACIN N-OCTYL AMIDE

CAS No.
282728-65-8
Chemical Name:
INDOMETHACIN N-OCTYL AMIDE
Synonyms
INDOMETHACIN N-OCTYL AMIDE;N-OCTYL-1-(4-CHLOROBENZOYL)-5-METHOXY-1H-INDOLE-3-ACETAMIDE;2-[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]-N-octylacetamide;1H-Indole-3-acetamide, 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-N-octyl-
CBNumber:
CB7490411
Molecular Formula:
C27H33ClN2O3
Molecular Weight:
469.02
MDL Number:
MFCD03412026
MOL File:
Mol file
Last updated:2023-05-21 10:59:17

INDOMETHACIN N-OCTYL AMIDE Properties

storage temp. Store at -20°C
solubility ≤2mg/ml in ethanol;27mg/ml in dimethyl formamide
form crystalline solid

INDOMETHACIN N-OCTYL AMIDE price More Price(8)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 70273 Indomethacin N-octyl amide ≥98% 282728-65-8 1mg $25 2024-03-01 Buy
Cayman Chemical 70273 Indomethacin N-octyl amide ≥98% 282728-65-8 5mg $107 2024-03-01 Buy
Cayman Chemical 70273 Indomethacin N-octyl amide ≥98% 282728-65-8 10mg $186 2024-03-01 Buy
Cayman Chemical 70273 Indomethacin N-octyl amide ≥98% 282728-65-8 50mg $807 2024-03-01 Buy
ApexBio Technology C5591 IndomethacinN-octylamide 282728-65-8 50mg $922 2021-12-16 Buy
Product number Packaging Price Buy
70273 1mg $25 Buy
70273 5mg $107 Buy
70273 10mg $186 Buy
70273 50mg $807 Buy
C5591 50mg $922 Buy

INDOMETHACIN N-OCTYL AMIDE Chemical Properties,Uses,Production

Biological Activity

indomethacin n-octyl amide is a potent and non-selective inhibitor of both cox-1 and cox-2 [1].cyclooxygenase (cox) is the key enzyme required for the conversion of arachidonic acid to prostaglandins. cyclooxygenase enzymes have been involved in diverse physiological situations and disease processes ranging from inflammation to cancer. until now, two cyclooxygenase isoforms have been identified, cox-1 and cox-2. the cox-1 enzyme is produced constitutively (i.e., gastric mucosa) and cox-2 is inducible (i.e., sites of inflammation) [2].indomethacin is a potent but non-selective inhibitor of both cox-1 and cox-2. indomethacin is a substituted indole acetic acid, wherein the carboxylate can be derivitized as an ester or amide. conversion of indomethacin into ester and amide derivatives provides a facile strategy for generating highly selective cox-2 inhibitors. indomethacin n-octyl amide inhibited the activity of ovine cox-1 and human recombinant cox-2 with the ic50 values of 66 μm and 40 nm, respectively. while the ic50 of indomethacin for the inhibition of cox-1 and cox-2 were 0.67 μm and 0.05 μm, respectively [1].

References

[1] kalgutkar a s, marnett a b, crews b c, et al. ester and amide derivatives of the nonsteroidal antiinflammatory drug, indomethacin, as selective cyclooxygenase-2 inhibitors[j]. journal of medicinal chemistry, 2000, 43(15): 2860-2870.
[2] dubois r n, abramson s b, crofford l, et al. cyclooxygenase in biology and disease[j]. the faseb journal, 1998, 12(12): 1063-1073.

INDOMETHACIN N-OCTYL AMIDE Preparation Products And Raw materials

Raw materials

Preparation Products

INDOMETHACIN N-OCTYL AMIDE Suppliers

Global( 12)Suppliers
Supplier Tel Email Country ProdList Advantage
BOC Sciences 1-631-485-4226; 16314854226 info@bocsci.com United States 14059 65
MedBioPharmaceutical Technology Inc 021-69568360 18916172912 order@med-bio.cn China 8141 58
Shanghai Yifei Biotechnology Co. , Ltd. 021-65675885 18964387627 customer_service@efebio.com China 8739 58
ApexBio Technology -- sales@apexbt.com United States 6254 58
N-OCTYL-1-(4-CHLOROBENZOYL)-5-METHOXY-1H-INDOLE-3-ACETAMIDE INDOMETHACIN N-OCTYL AMIDE 2-[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]-N-octylacetamide 1H-Indole-3-acetamide, 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-N-octyl- 282728-65-8 C27H33ClN2O3