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ChemicalBook >> CAS DataBase List >> INDOMETHACIN N-OCTYL AMIDE

INDOMETHACIN N-OCTYL AMIDE

INDOMETHACIN N-OCTYL AMIDE price.
  • $25 - $997
  • Product name: INDOMETHACIN N-OCTYL AMIDE
  • CAS: 282728-65-8
  • MF: C27H33ClN2O3
  • MW: 469.02
  • EINECS:
  • MDL Number:MFCD03412026
  • Synonyms:N-OCTYL-1-(4-CHLOROBENZOYL)-5-METHOXY-1H-INDOLE-3-ACETAMIDE;INDOMETHACIN N-OCTYL AMIDE;2-[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]-N-octylacetamide;1H-Indole-3-acetamide, 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-N-octyl-
8 prices
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Brand
  • AK Scientific
  • ApexBio Technology
  • Cayman Chemical
Package
  • 1mg
  • 5mg
  • 10mg
  • 50mg
  • ManufacturerAK Scientific
  • Product number3386CR
  • Product descriptionN-Octyl-1-(4-chlorobenzoyl)-2-methyl-5-methoxy-1H-indole-3-acetamide
  • Packaging50mg
  • Price$997
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberC5591
  • Product descriptionIndomethacinN-octylamide
  • Packaging5mg
  • Price$119
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberC5591
  • Product descriptionIndomethacinN-octylamide
  • Packaging10mg
  • Price$210
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberC5591
  • Product descriptionIndomethacinN-octylamide
  • Packaging50mg
  • Price$922
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number70273
  • Product descriptionIndomethacin N-octyl amide ≥98%
  • Packaging1mg
  • Price$25
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number70273
  • Product descriptionIndomethacin N-octyl amide ≥98%
  • Packaging5mg
  • Price$107
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number70273
  • Product descriptionIndomethacin N-octyl amide ≥98%
  • Packaging10mg
  • Price$186
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number70273
  • Product descriptionIndomethacin N-octyl amide ≥98%
  • Packaging50mg
  • Price$807
  • Updated2024-03-01
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific 3386CR N-Octyl-1-(4-chlorobenzoyl)-2-methyl-5-methoxy-1H-indole-3-acetamide 50mg $997 2021-12-16 Buy
ApexBio Technology C5591 IndomethacinN-octylamide 5mg $119 2021-12-16 Buy
ApexBio Technology C5591 IndomethacinN-octylamide 10mg $210 2021-12-16 Buy
ApexBio Technology C5591 IndomethacinN-octylamide 50mg $922 2021-12-16 Buy
Cayman Chemical 70273 Indomethacin N-octyl amide ≥98% 1mg $25 2024-03-01 Buy
Cayman Chemical 70273 Indomethacin N-octyl amide ≥98% 5mg $107 2024-03-01 Buy
Cayman Chemical 70273 Indomethacin N-octyl amide ≥98% 10mg $186 2024-03-01 Buy
Cayman Chemical 70273 Indomethacin N-octyl amide ≥98% 50mg $807 2024-03-01 Buy

Properties

storage temp. :Store at -20°C
solubility :≤2mg/ml in ethanol;27mg/ml in dimethyl formamide
form :crystalline solid

Safety Information

Symbol(GHS):
Signal word:
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
Precautionary statements:

Description

Indomethacin is a potent but non-selective inhibitor of both COX-1 and COX-2 in sheep and humans. Structurally, indomethacin is a substituted indole acetic acid, wherein the carboxylate can be derivitized as an ester or amide. These derivatives show enhanced selectivity for the COX-2 isoform. For example, the IC50 values of indomethacin N-octyl amide for the inhibition of ovine COX-1 and human recombinant COX-2 are 66 μM and 40 nM, respectively, making it 1,650 times more potent as an inhibitor of COX-2 than COX-1. While indomethacin itself has an IC50 of 0.05 μM for the inhibition of COX-2, it also inhibits COX-1 with a corresponding IC50 of 0.67 μM.