PROXYPHYLLINE
- CAS No.
- 603-00-9
- Chemical Name:
- PROXYPHYLLINE
- Synonyms
- MT;7-(2-Hydroxypropyl)-1,3-dimethyl-3,7-dihydro-1H-purine-2,6-dione;Spasmolysin;PROXYPHYLINE;Thean;Theon;Brontyl;Spantin;Theoden;Sigophyl
- CBNumber:
- CB7492824
- Molecular Formula:
- C10H14N4O3
- Molecular Weight:
- 238.24
- MDL Number:
- MFCD00022833
- MOL File:
- 603-00-9.mol
Melting point | 134-136°C |
---|---|
Boiling point | 487.2±51.0 °C(Predicted) |
Density | 1.46±0.1 g/cm3(Predicted) |
storage temp. | Inert atmosphere,Room Temperature |
pka | 14.55±0.20(Predicted) |
form | Solid |
color | White to Off-White |
Water Solubility | 285.7g/L(temperature not stated) |
Merck | 14,7905 |
CAS DataBase Reference | 603-00-9(CAS DataBase Reference) |
EWG's Food Scores | 1 |
FDA UNII | 13G1DMN4P0 |
ATC code | R03DA03 |
NIST Chemistry Reference | Proxyphylline(603-00-9) |
PROXYPHYLLINE price More Price(40)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | S351288 | 7-(2-HYDROXYPROPYL)THEOPHYLLINE Aldrich | 603-00-9 | 1g | $179 | 2024-03-01 | Buy |
Sigma-Aldrich | P3800000 | Proxyphylline European Pharmacopoeia (EP) Reference Standard | 603-00-9 | p3800000 | $220 | 2024-03-01 | Buy |
TCI Chemical | H1430 | 7-(2-Hydroxypropyl)theophylline >98.0%(HPLC)(N) | 603-00-9 | 5g | $78 | 2024-03-01 | Buy |
TCI Chemical | H1430 | 7-(2-Hydroxypropyl)theophylline >98.0%(HPLC)(N) | 603-00-9 | 25g | $196 | 2024-03-01 | Buy |
Cayman Chemical | 20937 | Proxyphylline ≥98% | 603-00-9 | 500mg | $49 | 2024-03-01 | Buy |
PROXYPHYLLINE Chemical Properties,Uses,Production
Chemical Properties
White Solid
Uses
A metabolite of Theophylline in human plasma.
Definition
ChEBI: Proxyphylline is an oxopurine.
Biological Activity
ki: 82 nm for bovine brain a1 adenosine receptorproxyphylline is an a1 adenosine receptor antagonist.the a1 adenosine receptor, the best characterized purinergic receptor family, can mediate responses via multiple pertussis toxin-sensitive gtp binding proteins to various different effectors.
in vitro
previous study showed that proxyphylline could selectively antagonize a1 adenosine receptors versus a2 adenosine receptors (ki = 850 μm for platelets) [1].
in vivo
in a previous study, rats that were allodynic following the vincristine injections were randomly allocated into four groups. theoesberiven f (a combination of proxyphylline and melilotus extract) was administered to rats. results showed that the decreased paw withdrawal threshold induced by vincristine injection was increased by theoesberiven f treatment and the increased withdrawal frequency to cold stimuli was also reduced by theoesberiven f treatment [2].
Purification Methods
Crystallise it from EtOH, aqueous MeOH or EtOAc. Roth Archiv Pharmazie 292 234 1959, Zelnik et al. Bull Soc Chim Fr 1733 1956, Beilstein 26 III/IV 2366.]
References
[1] u. schwabe, d. ukena and m. j. lohse. xanthine derivatives as antagonists at a1 and a2 adenosine receptors. naunyn-schmiedeberg's arch.pharmacol. 330,212-221 (1985).
[2] s. bang, y. s. kim and s. r. jeong. anti-allodynic effect of theoesberiven f in a vincristine-induced neuropathy model. exp. ther. med. 12(2), 799-803 (2016).
[3] selvig k. pharmacokinetics of proxyphylline in adults after intravenous and oral administration. eur j clin pharmacol. 1981 jan;19(2):149-55.
PROXYPHYLLINE Preparation Products And Raw materials
Raw materials
Preparation Products
PROXYPHYLLINE Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Standardpharm Co. Ltd. | 86-714-3992388 | overseasales1@yongstandards.com | United States | 14336 | 58 |
CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49391 | 58 |
career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29825 | 58 |
SIMAGCHEM CORP | +86-13806087780 | sale@simagchem.com | China | 17367 | 58 |
Hefei TNJ Chemical Industry Co.,Ltd. | 0551-65418671 | sales@tnjchem.com | China | 34571 | 58 |
AFINE CHEMICALS LIMITED | +86-0571-85134551 | info@afinechem.com | China | 15395 | 58 |
Finetech Industry Limited | +86-27-87465837 +8618971612321 | info@finetechnology-ind.com | China | 9602 | 58 |
Baoji Guokang Healthchem co.,ltd | +8615604608665 15604608665 | dominicguo@gk-bio.com | CHINA | 9427 | 58 |
Dayang Chem (Hangzhou) Co.,Ltd. | 571-88938639 +8617705817739 | info@dycnchem.com | China | 52861 | 58 |
Henan Alfa Chemical Co., Ltd | +8618339805032 | alfa4@alfachem.cn | China | 13185 | 58 |
View Lastest Price from PROXYPHYLLINE manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
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2023-11-25 | PROXYPHYLLINE
603-00-9
|
US $35.68 / kg | 1kg | 99% | 100kg | Wuhan Han Sheng New Material Technology Co.,Ltd | |
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2023-11-25 | Monophylline, Spasmolysin
603-00-9
|
US $35.67 / kg | 1kg | 99% | 100kg | Wuhan Han Sheng New Material Technology Co.,Ltd | |
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2023-11-25 | Proxyphylline or 7-(2-Hydroxypropyl) Theophylline)
603-00-9
|
US $35.66 / kg | 1kg | 99% | 100kg | Wuhan Han Sheng New Material Technology Co.,Ltd |
-
- PROXYPHYLLINE
603-00-9
- US $35.68 / kg
- 99%
- Wuhan Han Sheng New Material Technology Co.,Ltd
-
- Monophylline, Spasmolysin
603-00-9
- US $35.67 / kg
- 99%
- Wuhan Han Sheng New Material Technology Co.,Ltd
-
- Proxyphylline or 7-(2-Hydroxypropyl) Theophylline)
603-00-9
- US $35.66 / kg
- 99%
- Wuhan Han Sheng New Material Technology Co.,Ltd
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